An aerosol-generating system is provided, including a nicotine source; and a delivery enhancing compound source, which includes a reaction product of one or both of: (i) an alpha-keto carboxylic acid and a compound of formula (I) ##STR00001## where R.sup.1 is selected from alkyl, phenyl, or substituted phenyl, and (ii) an alpha-hydroxy acid and a compound of formula (II) ##STR00002## where X is a halogen and R.sup.2 is selected from H, alkyl, phenyl, or substituted phenyl.

An aerosol-generating system is provided, including a nicotine source; and a delivery enhancing compound source, which includes a reaction product of one or both of: (i) an alpha-keto carboxylic acid and a compound of formula (I) ##STR00001## where R.sup.1 is selected from alkyl, phenyl, or substituted phenyl, and (ii) an alpha-hydroxy acid and a compound of formula (II) ##STR00002## where X is a halogen and R.sup.2 is selected from H, alkyl, phenyl, or substituted phenyl.

A method of manufacturing a flexible container housing a drug substance is disclosed that includes forming a first compartment from a flexible sheet-like material, filling a liquid into the first compartment, sealing the first compartment, forming a second compartment from the flexible sheet-like material, filling a dry drug formulation into the second compartment, and sealing the second compartment. The method further involves lyophilizing the drug formulation inside a tubular cartridge, filling the second compartment by introducing the tubular cartridge through an opening of the second compartment such that an open end of the tubular cartridge is positioned distant from the opening of the second compartment, providing the drug formulation from the open end of the tubular cartridge into the second compartment, and withdrawing the tubular cartridge from the second compartment. The first and second compartments are separated by a frangible seal which opens when the first compartment is compressed.

A method of manufacturing a flexible container housing a drug substance is disclosed that includes forming a first compartment from a flexible sheet-like material, filling a liquid into the first compartment, sealing the first compartment, forming a second compartment from the flexible sheet-like material, filling a dry drug formulation into the second compartment, and sealing the second compartment. The method further involves lyophilizing the drug formulation inside a tubular cartridge, filling the second compartment by introducing the tubular cartridge through an opening of the second compartment such that an open end of the tubular cartridge is positioned distant from the opening of the second compartment, providing the drug formulation from the open end of the tubular cartridge into the second compartment, and withdrawing the tubular cartridge from the second compartment. The first and second compartments are separated by a frangible seal which opens when the first compartment is compressed.

The disclosure provides a two-chamber carpule comprising two-chambers adapted to be joined together. Each chamber is adapted to contain a medicament component. The carpule further comprises a bevel arranged on a circumference of at least one of the chambers in a transition area. The bevel extends from one chamber to the other chamber.

The disclosure provides a two-chamber carpule comprising two-chambers adapted to be joined together. Each chamber is adapted to contain a medicament component. The carpule further comprises a bevel arranged on a circumference of at least one of the chambers in a transition area. The bevel extends from one chamber to the other chamber.

A refillable mastic cartridge for a mastic medium to be dispensed includes a rigid head part having a dispensing outlet, and a mastic cartridge chamber configured to store a component of the mastic medium to be dispensed from the mastic cartridge via the dispensing outlet.

A refillable mastic cartridge for a mastic medium to be dispensed includes a rigid head part having a dispensing outlet, and a mastic cartridge chamber configured to store a component of the mastic medium to be dispensed from the mastic cartridge via the dispensing outlet.

A method and system for filling a flexible film bag attached to a face plate with a flowable composition is disclosed. The system includes a chamber for receiving the flexible film bag and a fill tube for dispensing the flowable composition into the flexible film bag, where the fill tube is at least partially disposed in the film bag. The system also includes a first pump in fluid communication with the chamber, where the first pump creates a vacuum between an exterior surface of the flexible film bag and an interior surface of the chamber, such that the flexible film bag expands from an unexpanded state to an expanded state.

A device for facilitating a chemical reaction while submerged in a liquid catalyst includes an upper member, a lower member, and a dissolvable member disposed between and ultimately enclosed by said upper and lower members such that upper and lower chambers are formed having substantially equal volumes. The upper chamber may receive a dry sodium chlorite and the lower chamber may receive a dry acid mixture. In order to keep the device submerged in the liquid catalyst, an inert ballast may also be added to the upper and/or lower chamber, such as glass shards.