A vial assembly may include a vial having a body to hold a liquid material, and a neck extending from the body. The neck may include a multi-use surface configured to permit access to the liquid material. The vial assembly may include a cap to be received by the neck and to cover the multi-use surface. The cap may include a base having a first major surface, and a second major surface opposite of the first major surface, arms extending from the second major surface, and a rupturable reservoir of disinfectant material carried by the base between the first major surface and the second major surface. One or more of the first major surface and the second major surface may be flexible so as to rupture the rupturable reservoir when the cap is received by the neck.

A device is described for facilitating the preparation of therapeutic foam e.g. for the treatment of varicose veins. A pressurised vial contains a sclerosant liquid, e.g., polidocanol solution, and a sterile gas which is readily absorbed by the body, e.g., carbon dioxide, oxygen or a mixture of these gases. The vial is provided either with a specialised stopper/seal into which a syringe nozzle may be inserted or alternatively a septum seal which may be penetrated by a hypodermic needle. The quantities of gas and liquid and the pressure in the vial are pre-set so that, on connection of a syringe to the vial, a predetermined volume of both gas and liquid is transferred to the syringe, with the intention that the syringe is then used to make a foam by known means. The use of the vial ensures that the ratio of gas to liquid in the foam is standardised, and also provides a convenient way of packaging the gas and liquid and of filling the syringe in a sterile manner.

A cap for coupling to a medical adapter may include a housing with a closed top end and an open bottom end with legs that extend from the housing away from the bottom end. Members may extend from an inner surface of the legs to engage and secure the cap to a medical adapter or an insert configured to mate with a medical adapter. A cap may include angular ridges between a cap housing and an insert to permit rotation of the cap in single direction and prevent removal of the cap from a medical adapter. A cap may include hinged legs to permit the cap to be secured to a medical adapter by rotating the legs toward each other until a portion of a collar on each leg may be matingly joined around the medical adapter.

A fluid transfer hub has a first vessel closure, a second vessel closure, a gasket arranged between the first vessel closure and the second vessel closure, and a clamp at least partially surrounding the first vessel closure, the second vessel closure, and the gasket. The first vessel closure has a first body, one or more apertures extending axially through the first body, one or more first inserts extending axially through the one or more apertures, and a cast seal disposed within the first body and surrounding each first insert. The second vessel closure has a second body, one or more apertures extending axially through the second body, one or more second inserts extending axially through the one or more apertures, and a cast seal disposed within the second body and surrounding each second insert.

A method for manufacturing bubbles of the present invention includes: injecting an aqueous liquid 10 into a container 20 to a predetermined height; and vibrating the container at the number of revolution of equal to or high than 5,000 rpm such that the aqueous liquid 10 repeatedly collides with an inner surface of the container 20. According to the manufacturing, simply by vibrating the container 20 at a predetermined number of revolution, a large amount of bubbles 1 having a uniform size can be stably generated in the aqueous liquid 10. Furthermore, the vibrating the container 20 is preferably performed in a state where an internal pressure of the container 20 is higher than 1.0 atm.

A save-and-draw capping system may be snapped or otherwise attached/connected to the top of a liquid medicine bottle having a rubber surface that may be punctured using a syringe to draw medicine. Using the save-and-draw capping system, the rubber surface may be sealed after it has been punctured. A secondary seal may be used to apply pressure to the cap of the liquid medicine bottle. A draw attachment, such as a draw needle, may be attached to the save-and-draw cap so that a hose may be connected to the liquid medicine bottle when multiple injections are needed. The save-and-draw capping system may be removed from one liquid medicine bottle to be used on another liquid medicine bottle.

A method for sealingly closing a bottle (1) is described, the method comprising the steps of: providing a cage (1009, a closing stopper (200) and a capsule (300); joining the stopper to the cage and the cage to the capsule (300), obtaining a preassembled closing assembly; aligning the closing assembly on the mouth of the bottle and exerting a pressure so as to sealingly close the bottle, wherein the annular relief of the cage (100) comes into contact with the bottle before the stopper comes into contact with the bottle.

A closure device for closing a container is provided. The closure device (10) includes a ring (28), a cover (30) and a cap (32). The ring has a top wall (34) and a flexible skirt (36) extending downwardly from the top wall. The flexible skirt includes a plurality of spaced-apart first legs (40) and a plurality of spaced-apart second legs (42) arranged in an alternating manner. Each of the first and second legs has a first end at the top wall and an opposing second end. The first legs are different from the second legs. An interior surface of each first leg has a first inwardly protruding ledge (44) between the first and second ends. Each second leg has a second inwardly protruding ledge (48) at the second end. An interior surface of each second leg has a flexible tongue (50) and a recess (52) configured to receive the flexible tongue. The tongues are adapted to retain an elastomer stopper (14).

A dispensing closure system includes an upper closure portion and a lower closure portion including an axial flow conduit and a vent conduit. The upper closure portion is axially movable relative to lower closure portion between shipping and dispensing positions. A seal is disposed on the lower closure portion over the flow and vent conduits. A peripheral spacing strip is removably secured to the upper closure portion and engages with either the lower closure or the outside of the container to prevent movement. A piercing probe includes piercing elements in alignment with the flow and vent conduits for piercing the seal. In the shipping position, the piercing elements are spaced from the seal. However, when the spacing strip is removed and the upper closure portion is axially moved to the dispensing position, the piercing elements pierce the seal to open the flow conduit and the vent conduit.