The present invention relates to an oral solid dosage form, in particular a tablet, comprising macitentan free base polymorphic form I.

A package has a first side coupled to a second side to form a space for storing material therebetween, the space having a re-sealable proximal end and a distal end. The first side has a plurality of layers, the plurality of layers having four layers selected from the group consisting of selected from the group consisting of OPP (oriented polypropylene film), KRAFT paper, VMPET (vacuum metallized polyester film), PE (polyethylene plastic), and PET (polyethylene terephthalate).

A package has a first side coupled to a second side to form a space for storing material therebetween, the space having a re-sealable proximal end and a distal end. The first side has a plurality of layers, the plurality of layers having four layers selected from the group consisting of selected from the group consisting of OPP (oriented polypropylene film), KRAFT paper, VMPET (vacuum metallized polyester film), PE (polyethylene plastic), and PET (polyethylene terephthalate).

The present invention is directed to an environmentally friendly composite structure and storage article fabricated therefrom. The composite structure includes a fiber-containing layer, such as a fiberboard layer or other layer having fibers from natural and/or synthetic sources, and a ground calcium carbonate-containing layer covering the fiber-containing layer. The ground calcium carbonate-containing layer is substantially continuously bonded to the fiber-containing layer along the surface of the fiber-containing layer. The fiber-containing layer and ground calcium carbonate-containing layer can be shaped, sized and manufactured such that the composite structure formed therefrom is capable of being shaped to form the storage article. The composite structure has advantages in that it has a high degree of pliability and flexibility that is increased over the pliability of the fiber-containing layer alone, which renders it highly attractive to consumers. The composite structure further has tensile strength and other characteristics that allow it to be readily machined into desired storage article forms, such as box and carton forms.

The present invention is directed to an environmentally friendly composite structure and storage article fabricated therefrom. The composite structure includes a fiber-containing layer, such as a fiberboard layer or other layer having fibers from natural and/or synthetic sources, and a ground calcium carbonate-containing layer covering the fiber-containing layer. The ground calcium carbonate-containing layer is substantially continuously bonded to the fiber-containing layer along the surface of the fiber-containing layer. The fiber-containing layer and ground calcium carbonate-containing layer can be shaped, sized and manufactured such that the composite structure formed therefrom is capable of being shaped to form the storage article. The composite structure has advantages in that it has a high degree of pliability and flexibility that is increased over the pliability of the fiber-containing layer alone, which renders it highly attractive to consumers. The composite structure further has tensile strength and other characteristics that allow it to be readily machined into desired storage article forms, such as box and carton forms.

This invention provides a method of treating a subject afflicted with a neurodegenerative disease comprising periodic administration of an amount of laquinimod and an amount of fingolimod, wherein the amounts when taken together are effective to treat the subject. Also provided are packages and pharmaceutical compositions comprising laquinimod and fingolimod for treating a subject afflicted with a neurodegenerative disease. Also provided is a pharmaceutical composition comprising laquinimod for use as an add-on therapy or in combination with fingolimod, and a pharmaceutical composition comprising fingolimod for use as an add-on therapy or in combination with laquinimod, for treating said subject.

This invention provides a method of treating a subject afflicted with a neurodegenerative disease comprising periodic administration of an amount of laquinimod and an amount of fingolimod, wherein the amounts when taken together are effective to treat the subject. Also provided are packages and pharmaceutical compositions comprising laquinimod and fingolimod for treating a subject afflicted with a neurodegenerative disease. Also provided is a pharmaceutical composition comprising laquinimod for use as an add-on therapy or in combination with fingolimod, and a pharmaceutical composition comprising fingolimod for use as an add-on therapy or in combination with laquinimod, for treating said subject.

A package of one or more absorbent articles is disclosed. The package has a package material including natural fibers. The package has a plurality of panels, including a consumer-facing panel, and wherein the package is sealed such that the one or more absorbent articles are completely enclosed therein. The package material has a basis weight of between 50 gsm to 120 gsm, between 60 gsm to 105 gsm or between 70 gsm to 90 gsm, as determined via ISO 536 as modified herein. The package material is recyclable.

A package of one or more absorbent articles is disclosed. The package has a package material including natural fibers. The package has a plurality of panels, including a consumer-facing panel, and wherein the package is sealed such that the one or more absorbent articles are completely enclosed therein. The package material has a basis weight of between 50 gsm to 120 gsm, between 60 gsm to 105 gsm or between 70 gsm to 90 gsm, as determined via ISO 536 as modified herein. The package material is recyclable.

This invention is a micro-featured surface with improved insulation and condensation resistance comprising: a micro-structure included with the substrate having an arrangement of a first set of micro-features and a second set of micro-features; a first micro-feature horizontal cross section taken from the group consisting of a circle, oval, polygon, and concave portion; a condensation rate less than 0.15 grams when measure by an ambient test method; and an improved hold time of 23.00% or greater as shown by hold testing wherein a micro-feature density is in a range of 5.00% to 25.00%.