This invention relates to a low cost rapid response diagnostic system to determine cortisol levels in patients selected as potential candidates for GCR (glucocorticoid receptor) antagonist therapy utilizing a GCR antagonist, such as ORG 34517. The rapid, sensitive, and inexpensive test can be used to determine patients who have non-normal cortisol production or disordered circadian rhythms as a method for selecting subjects for GCR antagonist therapy for whom it is likely to have beneficial and/or therapeutic effects, and can also be used to monitor changes in cortisol levels in response to treatment.

The present invention relates to a polymer blend and to multilayer heat shrinkable films containing at least a layer made of said polymer blend, to flexible containers made of said film, such as bags, pouches and the like, useful for packaging articles, in particular food items. The invention also relates to a process for the manufacturing of such multilayer heat shrinkable films.

To provide a method of producing scented tissue paper. The problem is solved by performing shrink wrapping in which a tissue paper housing obtained by carrying fragrance-containing microcapsules on an inner surface of a housing box using a binder is covered with a shrink film and the shrink film is exposed to hot air W so as to be attached to the tissue paper housing, causing the fragrance-containing microcapsules to be detached from the binder by heating the tissue paper housing at the time of the shrink wrapping, and providing the scent for plural sheets of tissue papers.

A storage bag includes first and second sidewalls each having a top edge, a top portion, and a bottom portion. The bottom portion of the first sidewall includes at least one shift region about which the bag is capable of shifting. The shift region includes a score line, an indentation, or a crimp formed into the first sidewall. The top portions of the sidewalls include a cuff line about which the bag is capable of shifting. The bag shifts between (i) a flat configuration with the sidewalls positioned adjacent to each other, and (ii) a stand-up configuration with the sidewalls separated from each other. In the stand-up configuration, the bag has a substantially flat base. The bag also can be shifted to a cuffed position with the bag being folded over the cuff line of each of the sidewalls such that the cuff region forms an opening to the bag.

In a film molded article (1) of the present invention, a plurality of concave or convex embossed portions (3) disposed apart from each other are formed on a surface (2a) of a film (2), and the plurality of embossed portions (3) are disposed on the surface of the film (2) to form an enclosed region (4) surrounded by the plurality of embossed portions (3) and imaginary lines (4a) that connect the plurality of embossed portions (3).

This invention relates to a low cost rapid response diagnostic system to determine cortisol levels in patients selected as potential candidates for GCR (glucocorticoid receptor) antagonist therapy utilizing a GCR antagonist, such as ORG 34517. The rapid, sensitive, and inexpensive test can be used to determine patients who have non-normal cortisol production or disordered circadian rhythms as a method for selecting subjects for GCR antagonist therapy for whom it is likely to have beneficial and/or therapeutic effects, and can also be used to monitor changes in cortisol levels in response to treatment.

An improved sealant packaging and method for use with sealing joints and cracks in pavement and parking lots is provided. Liquid sealant material is poured by volume into a container draped with a sheet. Container is cooled so that the sealant becomes a solid block, with the sheet adhered to the sides of the sealant block such that the sheet forms a container for the sealant. The sheet also acts a release liner for easily removing the sealant block from the container. Two or more contained blocks are stacked together, forming a package of two or more blocks self-sealed by sheets. When the package is placed in a melting kettle, heat migrates through the spaces between the individual sealant blocks and allows the smaller sealant blocks to melt quickly and evenly. Sheet and film melt with sealant material and are incorporated therein to form the final sealant product.

This invention relates the use of cortisol blockers (glucocorticoid receptor [GR] antagonists) for the treating or preventing treatment resistant prostate cancer, treating or preventing neoplasia, and treating or preventing infection related to acute or chronic injury or disease.

In alternative embodiments, the invention provides compositions and methods for overcoming or diminishing or preventing Growth Factor Inhibitor resistance in a cell, or, a method for increasing the growth-inhibiting effectiveness of a Growth Factor inhibitor on a cell, or, a method for re-sensitizing a cell to a Growth Factor Inhibitor, comprising for example, administration of a combination of a TBK1 inhibitor and an RTK inhibitor. In alternative embodiments, the cell is a tumor cell, a cancer cell or a dysfunctional cell. In alternative embodiments, the invention provides compositions and methods for determining: whether an individual or a patient would benefit from or respond to administration of a Growth Factor Inhibitor, or, which individuals or patients would benefit from a combinatorial approach comprising administration of a combination of: at least one growth factor and at least one compound, composition or formulation used to practice a method of the invention, such as an NFKB inhibitor, such as a lenalidomide or a REVLIMID, or IKK inhibitor; or an inhibitor of Galectin-3.

A storage bag includes first and second sidewalls each having a top edge, a top portion, and a bottom portion. The bottom portions of the sidewalls include at least one shift region about which the bag is capable of shifting. The shift region includes a score line, an indentation, or a crimp formed into the first sidewall. The top portions of the sidewalls include a cuff line about which the bag is capable of shifting. The bag shifts (a) between (i) a flat configuration with the sidewalls positioned adjacent to each other, and (ii) a stand-up configuration with the sidewalls separated from each other. In the stand-up configuration, the bag has a substantially flat base. The bag also can be shifted to a cuffed position with the bag being folded over the cuff line of each of the sidewalls such that the cuff region forms an opening to the bag.