Embodiments of the present invention provide an osseointegrative implant and related tools, components and fabrication techniques for surgical bone fixation and dental restoration purposes. In one embodiment an all-ceramic single-stage threaded or press-fit implant is provided having finely detailed surface features formed by ceramic injection molding and/or spark plasma sintering of a powder compact or green body comprising finely powdered zirconia. In another embodiment a two-stage threaded implant is provided having an exterior shell or body formed substantially entirely of ceramic and/or CNT-reinforced ceramic composite material. The implant may include one or more frictionally anisotropic bone-engaging surfaces. In another embodiment a densely sintered ceramic implant is provided wherein, prior to sintering, the porous debound green body is exposed to ions and/or particles of silver, gold, titanium, zirconia, YSZ, α-tricalcium phosphate, hydroxyapatite, carbon, carbon nanotubes, and/or other particles which remain lodged in the implant surface after sintering. Optionally, at least the supragingival portions of an all-ceramic implant are configured to have high translucence in the visible light range. Optionally, at least the bone-engaging portions of an all-ceramic implant are coated with a fused layer of titanium oxide.

A dental all-ceramic restoration and manufacturing method thereof; the outer surface of the dental all-ceramic restoration has neither visible marks remaining from the removal of the connecting bars (7) nor local grinding traces and chipping, and is smooth with uniform structure. The manufacturing method thereof is wet-forming or milling. No connecting bars are needed to connect the dental restoration bodies (3) with a surrounding mould blank or ceramic blank. This eliminates the need for manually cutting off the connecting bars (7) to separate the forming body from the surrounding ceramic blank, further grinding and polishing process to treat the excessively rough outer surface, and thereby reducing the risk of chipping and premature failure. In the manufacturing processes thereof, the hardened ceramic green body (2) made by wet-forming technique has more homogenous microstructure and less particle packing defects than the dry-pressed blanks and partially sintered blanks. Furthermore, higher surface smoothness can be obtained by milling unsintered hardened ceramic green body than by milling partially sintered blanks. The dental all-ceramic restoration has a high degree of surface finish, and can be directly used without polishing, veneering or glazing.

An isolated peptide is disclosed. The peptide comprises a titanium oxide binding amino acid sequence connected to a heterologous biologically active amino acid sequence via a beta sheet breaker linker, wherein: (i) the titanium oxide binding amino acid sequence is selected to bind coordinatively with titanium oxide; (ii) the titanium oxide binding amino acid sequence is selected to induce a beta sheet structure; and (ii) the titanium oxide binding amino acid sequence binds to titanium oxide with a higher affinity than said biologically active amino acid sequence binds to the titanium oxide under physiological conditions. Use of the peptides and titanium devices comprising same are also disclosed.

Endosseous implant to be applied to a human or animal bone, wherein the surface of the implant is made from titanium or a titanium alloy, said implant having a smooth or rough surface texture, which is characterized in that said surface has been treated with at least one selected organic phosphonate compound or a pharmaceutically acceptable salt or ester or an amide thereof; process for producing said implants.

Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.

An implant or endoprosthesis suitable to be implanted in human or animal tissue includes two (or more than two) parts to be joined in situ. Each one of the parts includes a joining location, the two joining locations facing each other when the device parts are positioned for being joined together, wherein one of the joining locations includes a material which is liquefiable by mechanical vibration and the other one of the joining locations includes a material which is not liquefiable by mechanical vibration and a structure (e.g. undercut cavities or protrusions) suitable for forming a positive fit connection with the liquefiable material. The joining process is effected by pressing the two device parts against each other and by applying ultrasonic vibration to one of the device parts when the two parts are positioned relative to each other such that the two joining locations are in contact with each other.

Body made of a ceramic material, the body having as an integral part thereof a surface region reaching from the surface of the body down to a predetermined depth. According to the invention, the surface region is enriched with a magnesium component thereby forming a hydrophilic surface area.

A dental implant with a specialized thread arrangement is disclosed. The dental implant includes a cylindrical upper section and a tapered lower section coupled to the cylindrical upper section. A helical thread is located on the exterior surface of the cylindrical upper section and the tapered lower section. A path is defined by the helical thread. The helical thread has a section on the exterior surface of the cylindrical body section and a section on the tapered body section. A cutting tooth is formed on the helical thread below where the thread section on the cylindrical body section transitions into the thread section on the tapered body section. The cutting tooth allows minimal torque to be applied to create stability of the implant by cutting into the dense part of the bone.

A medical device includes a shaft portion with a hollow shape and inflected portions or an exposed portion. The shaft portion is inserted into a cortical bone or penetrates through the cortical bone and is inserted to a position reaching a cancellous bone at an inner side of the cortical bone. The inflected portions are inflected to radial direction outer sides from one end portion of an axial direction of the shaft portion, and are exposed at a surface of the cortical bone. The exposed portion includes a portion that extends to the radial direction outer side from the one end portion of the axial direction of the shaft portion, and is exposed at the surface of the cortical bone.

A method for manufacturing a dental implant apparatus that comprises an implant and an implant support that can be placed next to one another by contact surfaces and that have contours providing security against rotation that are integrally molded on in one piece. The implant and an implant support have mutually matching contours that prevent a rotation of the implant and the implant support when placed next to one another. A tool system for carrying out the described methods and a dental implant apparatus that is manufactured in a corresponding manner are further disclosed. A contact surface of the implant is ground using a first grinding gauge that has a grinding surface having the shape of the contact surface of the implant attachment but not having the shape of the contour providing security against rotation of the implant. The contact surface of the implant support is ground using a second grinding gauge that has a grinding surface having the shape of the contact surface of the implant but not having the shape of the contour providing security against rotation of the implant support.