A medical implant includes a base portion configured for implantation into a bone of a patient. The base portion is formed from an electrically insulating and biocompatible base material with retaining features on an outer surface of the base portion for gripping the bone in the patient and at least two discontinuous regions formed of titanium on the outer surface.

A medical appliance or prosthesis may comprise one or more layers of rotational spun nanofibers, including rotational spun polymers. The rotational spun material may comprise layers including layers of polytetrafluoroethylene (PTFE). Rotational spun nanofiber mats of certain porosities may permit tissue ingrowth into or attachment to the prosthesis. Additionally, one or more cuffs may be configured to allow tissue ingrowth to anchor the prosthesis.

The invention relates to a biohybrid for the use thereof in the regeneration of neural tracts, comprising an implantable tubular hybrid structure which is degradable and biocompatible and characterized in that it comprises three layers of different porosity: an inner layer a), an intermediate layer b) and an outer layer c), with uninterrupted connection among them, the three layers consisting of the same porous hydrogel based on cross-linked hyaluronic acid, a biohybrid comprising the hybrid tubular structure described, which can contain a fibrous material, preferably poly-L-lactic acid, to a method for producing said tubular hybrid structure and said biohybrid, and to the use of same for regenerating neural tracts in diseases that affect the central nervous system, preferably Parkinson's disease.

An improved abdominal hernia repair system is presented comprised of a silicone layer backed up with a knitted or woven polypropylene fabric layer, the silicone layer possessing a regular pattern of slits that permit equilibration of fluid pressure across the device. A variety of therapeutic substances can be applied to the hernia repair device to promote healing, including aloe and other medicinal preparations. A layer of water soluble or water insoluble anti-scar compound is also present, the preferred compound being Salinomycin.

An improved inguinal hernia repair system is presented that is identical to the above except it does not contain the hydrophobic silicone component.

The present invention provides valve prostheses adapted to be initially crimped in a narrow configuration suitable for catheterization through body ducts to a target location and adapted to be deployed by exerting substantially radial forces from within by means of a deployment device to a deployed state in the target location.

The invention is an improved biocompatible surface for a variety of medical purposes. The biocompatible surface employs a unique tight microstructure that demonstrates enhanced cellular response in the body, particularly when placed in contact with blood. As a blood contact surface, the present invention can be beneficially employed in a wide variety of implantable devices and in many other devices and equipment that come in contact with blood.

A blood flow regulator for creating a shunt in the heart, comprising; a proximal element having a general disc-shape, defined by a braid of one or more wires extending about a central aperture of the proximal element; a distal element having a general disc-shape, defined by a braid of one or more wires extending about a central aperture of the distal element; and a third element defining a neck section intermediate the proximal and distal elements and forming a cavity having a diameter no greater than a diameter of each of the distal and proximal elements, wherein said distal element comprises at least one loop of a wire extending radially outwardly from a center of the distal element and returning towards said center of said distal element.

Implantable medical devices and prosthesis for rapid regeneration and replacement of tissues, and methods of making and using the devices, are described. The medical devices include a complex three-dimensional braided scaffold with a polymer composition and structure tailored to desired degradation profiles and mechanical properties. The composite three-dimensional braided scaffolds are braided from yarn bundles of biodegradable and bioresorbable polymeric fibers and/or filaments. Monofilament fibers and/or multifilament fibers can be twisted/plied in different combinations to form multifilament yarns, composite multifilament yarns, or composite yarns. The medical devices are useful as both structural prosthetics taking on the function of the tissue as it regenerates and as in vivo scaffolds for cell attachment and ingrowth.

Methods of implanting a device in the lumen of a blood vessel are described. The method includes providing a microcatheter and a device. The device includes a first hub, a second hub, a support structure including a plurality of struts disposed between the first hub and the second hub, and a layer of material disposed over the plurality of struts. The support structure has a low profile, radially constrained state with an elongated tubular configuration suitable for delivery from a microcatheter. The support structure also has an expanded state, a smooth outer surface, and has an axially shortened configuration relative to the radially constrained state. The microcatheter is advanced to a region of interest within the blood vessel. The support structure is advanced through the lumen of and out the distal end of the microcatheter where it expands to the expanded state.

The present invention relates to a prosthetic fabric comprising an arrangement of yarns defining at least two faces for said fabric, said fabric comprising, on at least one of its faces, one or more barbs that protrude outwards relative to said face, characterized in that said barbs are covered with a coating made of a water-soluble biocompatible material. The invention also relates to a process for obtaining such a fabric and to prostheses obtained from such a fabric.