A device for automated or manual group separations of complex biological mixtures and methods of use are described. The device is a gel filtration pipette tip having a size exclusion media therein and held in place by a filter at the distal end of the pipette tip and an optional removable or pierceable barrier at the proximal end of the pipette tip. The size exclusion media is wetted by aspirating a solvent from the bottom of the pipette tip and equilibrating the solvent with the size exclusion media. The solvent is then allowed to gravity drain from the pipette tip, allowing the size exclusion media to settle and reproducibly pack into a homogenous gel. Gel filtration separations can then be performed with the gelled size exclusion media.

A method of inhibiting degradation of an extractant by utilizing several auxiliary means in the DSX process: includes (a) preparing adjustment of the concentration of an extractant of a DSX solvent to a certain range; (b) extracting a metal contained in a pregnant leached solution by adjusting the ratio of the extractant and the diluent in the DSX solvent to a certain range; (c) measuring the pH of the aqueous phase solution by separating mixture into the aqueous phase solution and the organic phase solvent using a settler after step of extracting; (d) controlling the pH by adding soda ash (Na.sub.2CO.sub.3) so as to maintain the pH of the aqueous phase solution to be 3 to 7; and (e) scrubbing with scrubbing solution having a zinc concentration of 2 to 20 g/L by zinc sulfate (ZnSO.sub.4) to remove the manganese from the organic phase solvent containing the extracted metal.

Provided is a method of inhibiting degradation of an extractant by an anhydrous environment avoiding and metal stripping, the method including the steps of: (a) stopping the addition of soda ash (Na.sub.2CO.sub.3) to an extracting reaction tank; (b) starting solution recirculation and stopping solvent recirculation of a settler; (c) supplying a solvent from a loaded organic tank to a scrubbing reaction tank, in which the scrubbing reaction tank, stripping reaction tank and extracting reaction tank are connected for circulation and operating stirrers of the scrubbing reaction tank, stripping reaction tank and extracting reaction tank; (d) supplying a sulfuric acid solution having a controlled concentration with a diluting solution to the stripping reaction tank; (e) transferring the solvents of the settler, the loaded organic tank and all the pipes to the scrubbing reaction tank; and (f) stopping the step (e) and initiating solvent recirculation.

Various uses of monochlorotrifluoropropenes, in combination with one or more other components, including other fluoroalkenes, hydrocarbons; hydrofluorocarbons (HFCs), ethers, alcohols, aldehydes, ketones, methyl formate, formic acid, water, trans-1,2-dichloroethylene, carbon dioxide and combinations of any two or more of these, in a variety of applications, including as blowing agents, are disclosed.

The present disclosure relates to molecularly imprinted polymers that target cannabinoid(s), including THC and CBD, as well as methods of making molecularly imprinted polymers that target cannabinoid(s), including THC and CBD and uses thereof.

The present invention is directed to a method of producing active pharmaceutical ingredients (APIs). The method includes subjecting a reaction mixture with an API precursor to solvent extraction to produce a reactant stream with the API precursor. The method includes concentrating the API precursor in the reactant stream using at least one membrane. The method includes carrying out a reaction in a membrane reactor. The method includes separating the API precursor from the reaction stream using a separator. The method includes crystallizing the API precursor using a crystallizer to produce APIs.

A method for chemical separation of cannabinoids includes: (i) providing a starting organic solvent solution that contains a mixture of cannabinoid acids, (ii) using an aqueous basic solution to remove a portion of the cannabinoid acids from the mixture of cannabinoid acids in the starting organic solvent solution by converting the portion of the cannabinoid acids to cannabinoid carboxylate salts that solubilize in the an aqueous basic solution, (iii) separating the aqueous basic solution in (ii) from the starting organic solvent, (iv) combining the aqueous solution from (iii) with new organic solvent to produce a combined solution, (v) acidifying the combined solution to extract the cannabinoid acids from the aqueous solution to the organic solvent, (vi) separating the organic solvent of (v) from the aqueous solution, and (vii) evaporating the organic solvent of (vi) to leave product cannabinoid acids.

A method of producing biodiesel using a conduit contactor in fluid communication with a collection vessel includes: introducing a first stream including an alcohol proximate a plurality of fibers positioned within the conduit contactor and extending proximate to the collection vessel; introducing a second stream including an oil into the conduit contactor proximate to the plurality of fibers, wherein the second stream is in contact with the first stream; reacting the oil and the alcohol to for a single phase; receiving the single phase in the collection vessel; and separating biodiesel from the single phase.

The invention relates to a THC-free cannabinoid concentrate, method of obtaining the same and use thereof. The method of obtaining comprises an alkaline wash to purify lipid extracts.

The present disclosure provides a formation method for a slag flow that includes combining a first liquid and a second liquid that is not compatible with the first liquid, moving the second liquid that is combined with the first liquid to an upstream side with respect to a combination point of the first liquid and the second liquid in a flow direction of the first liquid, and moving, by the first liquid, the second liquid that is retained on the upstream side with respect to the combination point of the first liquid and the second liquid in the flow direction of the first liquid, to a downstream side with respect to the combination point of the first liquid and the second liquid in the flow direction of the first liquid, where a density D1 of the first liquid and a density D2 of the second liquid satisfy a relationship of D1>D2, and provides an application thereof.