A detachable cooling apparatus comprises: a distal miming catheter forming a distal lumen that provides liquid as an input and a proximal miming catheter forming a proximal lumen that receives the liquid as an output, where the proximal miming catheter is connected to the distal running catheter. A focal hypothermia-inducing fluidics system comprises a thermal management and flow system (TMFS) that is operable to alter a liquid to a specific temperature and to regulate a flow rate, a closed-circuit flow system with a detachable cooling apparatus, a distal sensor array, a pump for moving the liquid through the TMFS, an inflow port that receives the liquid from the proximal running catheter, a plurality of capillary tubes that cool the liquid, and an outflow port that returns the liquid to the distal miming catheter.

A cold/hot compress strip device with a quick replaceable compress strip and an efficient cold/hot switch includes a host machine and a flexible compress strip fixable to an affected part on a human body surface, and the host machine can pump the cooled cold water from its container into the compress strip and circulate the cold water in the compress strip for cold compress, or can quickly discharge the cold water in the compress strip, and drive a heating film on the compress strip to generate heat for hot compress, so as to achieve an efficient cold/hot switch, and the compress strip can be replaced quickly as needed. The application of the cold/hot compress strip device is very simple and practical.

A cold/hot compress device with efficient cold/hot switch and quick compress strip replacement includes a host machine and a flexible compress strip, and the host machine can pump the cooled water into the compress strip for a cold compress of an affected part on a human body surface and also can quickly discharge the cold water contained in the compress strip and drive a heating film to generate heat for a hot compress without the need of heating the cold water for an efficient cold/hot switch. The flexible compress strip can be replaced quickly as needed, and its application is very simple and practical.

Proposed is a filter fixing module mounted to a handpiece cooling device having a connecting unit such that a refrigerant supply unit is coupled thereto, the filter fixing module including a body having a support surface formed in a plate shape, and a receiving surface formed on an edge of the support surface and protruding in a first direction relative to the support surface so as to prevent removal of a filter received in the support surface, and a grip unit connected to the body, wherein the grip unit comprises a first grip member and a second grip member extending in directions opposite to the protruding direction of the receiving surface relative to the body.

The present disclosure provides systems and method for medical ice slurry production. In particular, systems and methods are provided for medical ice slurry production that enable an end user to produce and deliver a sterile medical ice slurry at the point of care.

The present invention provides a cold solution and method for inducing therapeutic hypothermia. The cold solution can comprise liquid and/or solid ice particles.

Various implementations include a Human Thermoregulation Simulator (HTRS) that simulates the natural and primary thermoregulatory functions of a patient that are relevant during therapeutic hypothermia procedures. For example, in various implementations, a HTRS includes a core container configured to be at least partially filled with water, and the core container includes a heat generator configured to heat the water inside the core container. A middle container is disposed concentrically around the core container, and the middle container includes a foam layer configured to be saturated by water. An outer container is disposed concentrically around the middle container, and the outer container includes a network of tubing disposed on at least a portion of an inner surface of the outer container. The HTRS also includes a pump configured to circulate water from the core container through the network of tubing.

Methods of treating tumors by administering compounds to a patient are provided. Compounds such as pro drugs, e.g., 5-aminolevulinic acid (5-ALA), may be administered to the patient orally, by injection, intravenously, or topically, which then accumulate preferentially as compounds such as protoporphyrin IX (PpIX) in tumor cells. After such accumulation, compounds such as PpIX are then activated in various aspects to treat tumors cells, thereby treating cancer. Cancers such as glioblastoma may be treated.

A patient temperature control system for automated temperature control according to a programmed protocol. In one aspect, at least one programmed protocol may be established for each of a plurality of patient thermal therapy phases. In turn, the temperature of a thermal exchange medium may be controlled upon the programmed protocol during each of the phases. A plurality of programmed protocols may be established, wherein a selected protocol may be utilized for automated temperature control during patient thermal therapy. The protocol may include a target patient temperature and/or a set duration for one or more of the phase of thermal therapy. The protocol may be user-definable and modifiable during therapy. In a multiphase configuration, automatic termination and initiation of successive phases may be selectively established by a user, based on target patient temperature data and/or set duration data on a phase-specific basis.

Systems and methods include a heat transfer body with opposing major surfaces formed from a thermally conductive substrate in intimate thermal interaction with an alumina exterior surface that extends across the major surfaces of the body. In an illustrative example, the heat source may be a substantially planar, silicone-based heater source (P-SBHS). The heat transfer body may be configured to thermally interact, for example, heat from a heat source proximate a first of the major surfaces to a second of the major surfaces. A temperature sensor module may be located, for example, proximate to the first major surface such that a temperature sensor thermally interacts with the first major surface. The temperature sensor module may, for example, insulate the temperature sensor from the P-SBHS.