A filter element comprises a filter media for filtering a fluid, an endcap positioned at an axial end of the filter media, and a seal member. The endcap comprises a main wall that defines a central aperture. The seal member is positioned within the central aperture of the endcap and is adhered to the endcap.

A filter element comprises a filter media for filtering a fluid, an endcap positioned at an axial end of the filter media, and a seal member. The endcap comprises a main wall that defines a central aperture. The seal member is positioned within the central aperture of the endcap and is adhered to the endcap.

An adapter for use in a filter device is provided, the adapter having a downwardly slanted inner wall including two or more hollow passageways, and a central fluid flow port, wherein the adapter can be welded to a filter device housing head.

An adapter for use in a filter device is provided, the adapter having a downwardly slanted inner wall including two or more hollow passageways, and a central fluid flow port, wherein the adapter can be welded to a filter device housing head.

A filter arrangement includes first and second media packs with a support core in between. The support core includes a first ring at one end and, optionally, second ring at an opposite end. In some arrangements, at least a first member and second member extend from the first ring while being engagement-free to each other. In some arrangements, no more than a first member extends from the first ring, while being engagement-free relative to itself.

A filter arrangement includes first and second media packs with a support core in between. The support core includes a first ring at one end and, optionally, second ring at an opposite end. In some arrangements, at least a first member and second member extend from the first ring while being engagement-free to each other. In some arrangements, no more than a first member extends from the first ring, while being engagement-free relative to itself.

Systems and methods for containing and manipulating liquids, including vessels and unit operations or components of cell culture, cell containment, bioreactor, and/or pharmaceutical manufacturing systems, are provided. The apparatus may include a disposable, collapsible bag adapted for containing a liquid, the collapsible bag in fluid communication with a liquid-solids (e.g., cell) separation device. For example, an outlet of the collapsible bag may be connected to an inlet of the separation device, and an outlet of the separation device may be connected to an inlet of the collapsible bag for recycle. Accordingly, after separating the cells from the liquid in the separation device, the cells can be flowed back into the collapsible bag where they can be re-harvested. Meanwhile, product contained in the liquid can be collected in a separate container. The efficiency of product formation in such a system may be enhanced by using mixing systems described herein.

Systems and methods for containing and manipulating liquids, including vessels and unit operations or components of cell culture, cell containment, bioreactor, and/or pharmaceutical manufacturing systems, are provided. The apparatus may include a disposable, collapsible bag adapted for containing a liquid, the collapsible bag in fluid communication with a liquid-solids (e.g., cell) separation device. For example, an outlet of the collapsible bag may be connected to an inlet of the separation device, and an outlet of the separation device may be connected to an inlet of the collapsible bag for recycle. Accordingly, after separating the cells from the liquid in the separation device, the cells can be flowed back into the collapsible bag where they can be re-harvested. Meanwhile, product contained in the liquid can be collected in a separate container. The efficiency of product formation in such a system may be enhanced by using mixing systems described herein.

A phase separation device having a device housing (2) accommodating at least one coalescer element (42), wherein said device housing (2) has an inlet (38) for the supply of an emulsion, which flows through the respective coalescer element (42) for separation into at least two of its constituents; an outlet (46) for a separated constituent; and a further outlet (22, 64) for a further separated constituent having a lower density than the one constituent and floating on the latter.

A phase separation device having a device housing (2) accommodating at least one coalescer element (42), wherein said device housing (2) has an inlet (38) for the supply of an emulsion, which flows through the respective coalescer element (42) for separation into at least two of its constituents; an outlet (46) for a separated constituent; and a further outlet (22, 64) for a further separated constituent having a lower density than the one constituent and floating on the latter.