A thermal control unit for delivering temperature-controlled fluid to one or more patient pads that are in contact with a patient is disclosed. The thermal control unit includes a fluid circuit with an inlet and outlet, a heat exchanger, a pump, and a controller. A fluid quality monitor is included in some embodiments to monitor a cleanliness of the circulating fluid and issue an alert if the cleanliness falls below a threshold. A valve may be included that is controlled by the controller based upon a measurement of the cleanliness of the circulating fluid and/or the passage of a predetermined amount of time. A second valve may also be included in some embodiments that selectively diverts fluid to an additional filter. The additional filter is used to determine if a cleaning action taken with respect to the circulating fluid was effective or not.

Embodiments of the disclosure provide a filtration assembly. The filtration assembly includes a fluid inlet, a fluid outlet, first and second flow lines positioned fluidly between the fluid inlet and the fluid outlet, a differential pressure sensor, and a controller. The first flow line includes a first canister filter, a first filter housing, and a first valve configured to move between a closed position and an open position. The second flow line includes a second canister filter, a second filter housing, and a second valve configured to move between a closed position and an open position. The controller is configured to receive, from the differential pressure sensor, a differential pressure value, and when the differential pressure value is greater than a threshold value, generate a signal to one of the first and second valves to close the respective valve.

A filter assembly includes a filter media for filtering a fluid, and a valve having a fluid inlet and a fluid outlet for controlling a flow of the fluid through the filter assembly. The valve includes a thermally active element that changes shape between a first configuration and a second configuration in response to a temperature variation. When the thermally active element is in the first configuration the valve is open with the fluid inlet in fluid communication with the fluid outlet, and the thermally active element changes shape to the second configuration to close the valve. The thermally active element may move a valve poppet against a valve seat to close the valve. A pressure bypass is configured to open the valve in response to a pressure increase in the filter assembly above a threshold pressure when the thermally active element is in the second configuration.

Devices and methods for filtering, drying, and mechanically processing active pharmaceutical ingredients are generally described.

A thermostat assembly for use with an engine cooling system includes a thermostat, a frame, a bypass valve and an integrated filter. The frame supports the thermostat and is positioned upstream of a thermostatic valve. The frame also defines a primary coolant passage. The bypass valve is positioned on the frame and selectively defines a bypass coolant passage. The filter is positioned on the frame upstream of the thermostat and is configured to filter coolant flowing through the primary coolant passage to the thermostat. The bypass valve moves between a normally closed position and an open position where coolant is free to pass through the bypass coolant passage and to the thermostat. The bypass valve moves to the open position upon being subjected to a predetermined pressure caused by a reduction in a coolant flow rate through the filter so as to provide for coolant flow to bypass the filter.

A filter device includes: a filter element including a filtration member configured to filter a liquid and an IC tag including a first antenna coil; a filter case in which the filter element is installed; and a measurement unit installed in the filter case and including an antenna including a second antenna coil. The filter device performs transmission by magnetic resonance coupling between the first antenna coil and the second antenna coil. The filter case includes a partition wall that partitions an internal space into a first region provided with the filter element and a second region not provided with the filter element and is made of metal. The measurement unit includes a housing attached to the filter case. While the housing is disposed in the filter case, a tip end of the housing is inserted in the second region.

A coolant supply assembly includes an upper housing including a pre-filter mounting portion, a desiccant mounting portion, a pump mounting portion, and a main filter mounting portion on a top surface of the upper housing, the upper housing further including a flange portion at a first side surface of the upper housing and a coolant outlet at a second side surface opposite to the first side surface. The coolant supply assembly further includes a lower housing, the upper housing being mounted to the lower housing to define a coolant chamber, a pre-filter device mounted to the pre-filter mounting portion, a desiccant unit mounted to the desiccant mounting portion, a pump mounted to the pump mounting portion, a heat exchanger mounted to the flange portion, and a main filter device mounted to the main filter mounting portion.