Devices, systems and methods for controlling the temperature of all or part of the body of a human or animal subject.

Removable liquid heat exchanging element (100) for use in a device for temperature control treatment (400) comprising a support structure (300), and a liquid transporter (200) supported by the support structure (300). The removable liquid heat exchanging element (100) is configured to be positioned in a slot (402) in the device for temperature control treatment (400). The liquid transporter (200) comprises an inlet (201) and an outlet (206) and a lumen for liquid transportation. The lumen is at least partially enclosed by a heat exchanging portion (205) of a flexible wall configured to engage a heat exchanging surface (401a, 401b) of the device for temperature control treatment (400). The support structure (300) is configured to engage and partially enclose a portion of the liquid transporter (200) such that an occlusion (203) is formed between the inlet (201) and the heat exchanging portion (205) of the lumen for liquid transportation.

Removable liquid heat exchanging element (100) for use in a device for temperature control treatment (400) comprising a support structure (300), and a liquid transporter (200) supported by the support structure (300). The removable liquid heat exchanging element (100) is configured to be positioned in a slot (402) in the device for temperature control treatment (400). The liquid transporter (200) comprises an inlet (201) and an outlet (206) and a lumen for liquid transportation. The lumen is at least partially enclosed by a heat exchanging portion (205) of a flexible wall configured to engage a heat exchanging surface (401a, 401b) of the device for temperature control treatment (400). The support structure (300) is configured to engage and partially enclose a portion of the liquid transporter (200) such that an occlusion (203) is formed between the inlet (201) and the heat exchanging portion (205) of the lumen for liquid transportation.

A hands-free intraoral device for imparting a chilling treatment to a zone of intraoral tenderness within an oral cavity of a user. The hands-free intraoral device includes a carrier having a proximal end and a distal end. The distal end of the carrier is configured to be received within the oral cavity of the user and the proximal end of the carrier is configured to extend to a front and/or externally of the oral cavity of the user. A cooling element formed of a thermally conductive material selected to impart the chilling treatment to the zone of intraoral tenderness. A positioning element is operable to urge at least a portion of the cooling element in abutment with the zone of intraoral tenderness, providing for a hands-free positioning of the cooling element in abutment with the zone of intraoral tenderness.

A hands-free intraoral device for imparting a chilling treatment to a zone of intraoral tenderness within an oral cavity of a user. The hands-free intraoral device includes a carrier having a proximal end and a distal end. The distal end of the carrier is configured to be received within the oral cavity of the user and the proximal end of the carrier is configured to extend to a front and/or externally of the oral cavity of the user. A cooling element formed of a thermally conductive material selected to impart the chilling treatment to the zone of intraoral tenderness. A positioning element is operable to urge at least a portion of the cooling element in abutment with the zone of intraoral tenderness, providing for a hands-free positioning of the cooling element in abutment with the zone of intraoral tenderness.

Relatively non-invasive devices and methods for heating or cooling a patient's body are disclosed. Devices and methods for treating ischemic conditions by inducing therapeutic hypothermia are disclosed. Devices and methods for inducing therapeutic hypothermia through esophageal cooling are disclosed. Devices and methods for operative temperature management are disclosed.

Relatively non-invasive devices and methods for heating or cooling a patient's body are disclosed. Devices and methods for treating ischemic conditions by inducing therapeutic hypothermia are disclosed. Devices and methods for inducing therapeutic hypothermia through esophageal cooling are disclosed. Devices and methods for operative temperature management are disclosed.

A method of treating a subject in need thereof, is carried out by (a) administering said subject a therapeutic intervention (e.g., an active agent) in a treatment effective amount; and concurrently (b) administering said subject caloric vestibular stimulation in a treatment effective amount, said caloric vestibular stimulation administered so as to enhance the efficacy of said active agent. In some embodiments, the caloric vestibular stimulation is administered as an actively controlled time varying waveform.

A method of treating a subject in need thereof, is carried out by (a) administering said subject a therapeutic intervention (e.g., an active agent) in a treatment effective amount; and concurrently (b) administering said subject caloric vestibular stimulation in a treatment effective amount, said caloric vestibular stimulation administered so as to enhance the efficacy of said active agent. In some embodiments, the caloric vestibular stimulation is administered as an actively controlled time varying waveform.

A device for cooling locally, including a cooling member, a crystal having the capacity to cool via absorption of a near-infrared exciting light signal, an illuminating system intended to deliver an exciting light signal, the crystal having an elongate shape about a longitudinal axis between a near end and a far end and having a closed constant outside cross section and containing a central channel formed, from its far end, over at least some of its length, the cooling member including a rod embedded via a first end into the central channel of the crystal and including a protruding second end that forms a cooling finger.