A device for dispensing a metered dose of fluid is provided. The device comprises a housing comprising: a non-pressurised reservoir sized to accommodate a plurality of doses of fluid; a springloaded metering chamber sized to hold at least a single dose of fluid; a first valve enabling fluid communication between the reservoir and the metering chamber; and a kink valve enabling the fluid in the metering chamber to exit the device.

A device for injecting a therapeutic agent into an ocular implant at least partially implanted in an eye including an injection lumen providing a pathway for injecting the therapeutic agent into the implant; an outlet lumen providing a pathway for pre-existing fluid in the ocular implant to exit the implant; and a collection chamber fluidly coupled to the outlet lumen that provides a first fluid outflow resistance and a second fluid outflow resistance. The first fluid outflow resistance is lower than a first resistance to outflow of the implant. The second fluid outflow resistance is greater than a force imparted onto the implant by intraocular pressure of the eye. Injection of therapeutic agent into the implant via the injection lumen causes the pre-existing fluid to exit the implant and enter the collection chamber via the outlet lumen and causes a second pre-existing fluid to displace from the collection chamber.

Described herein is a generalized injection device for delivering formulations of various mechanical properties to precise locations. Of particular interest is the manifestation intended for the application of a thermally responsive hydrogel to the tear duct for the purpose of occlusion, as a treatment for symptoms associated with dry eye syndrome. Further, a modular solution to the need for an injection device across a variety of applications, mechanism, and physical considerations is provided. This disclosure provides examples of methods for precise injection of low volumes, moisture retention in pre-filled injection devices, and actuation for automatic or manual injection, to name a few.

The present invention discloses a robotic assisted system for ophthalmic surgery, comprising a first driving unit, a second driving unit and a third driving unit, wherein the three driving units can respectively complete the movement in three dimensions, the first driving unit is connected with the second driving unit, the second driving unit is connected with the third driving unit, and an instrument is arranged on the third driving unit; during operating, the third driving unit can drive the instrument assembly to move, the second driving unit can drive the third driving unit and instruments thereon to move, and the first driving unit can drive the second driving unit, the third driving unit on the second driving unit and the instruments on the third driving unit to move; the accurate control on the instruments can be completed by controlling the three different driving units. Through the specific RCM structure, the advantages of high precision and compact structure are achieved, and the present invention is suitable for various eye surgeries such as retinal bypass surgery, sub-retina injection and vitrectomy. The ophthalmic surgical device of the present invention has extremely high safety.

The present invention provides a drug composition comprising particles comprising a biodegradable or bioerodable polymer and a drug, a soluble, biodegradable or bioerodible excipient, a bulking agent and a reconstitution aid. The invention also provides a pharmaceutical formulation and a unit dosage form of the pharmaceutical formulation. The invention provides methods of treatment of a disease or condition accordingly. The invention also provides a drug composition for use in a cannulation device.

A system can include an aural computing system in communication with the ophthalmic device. In some embodiments, the aural computing system can include a wireless communication device in communication with the ophthalmic device. In some embodiments, the ophthalmic device comprises a contact lens, which can inserted into the user's eye. The wireless communication device can comprise wearable technology.

A flow control device for a compressible bottle may include a reservoir, the reservoir comprising an ophthalmic formulation disposed therein, the ophthalmic formulation comprising an ophthalmic agent and a preservative; a reservoir interface, disposed at a mouth of the reservoir, the reservoir interface comprising one or more apertures, the one or more apertures in the reservoir interface fluidically connecting an interior of the reservoir and an exterior of the reservoir; a nozzle, the nozzle comprising: an outlet and a nozzle cap, the nozzle cap comprising one or more apertures, the one or more apertures in the nozzle cap fluidically connecting the outlet and a reservoir-facing surface of the nozzle; and an axis of rotation, wherein rotation of the nozzle about the axis of rotation relative to the reservoir aligns the one or more apertures in the reservoir interface with the one or more apertures in the nozzle cap.

Certain embodiments provide an adjustable length infusion cannula having a cannula including a first proximal end and a first distal end, and a hub having a second proximal end, a second distal end, and a central aperture that extends between the second proximal end and the second distal end. The central aperture is configured to accept the first distal end of the cannula and allow the cannula upward movement and downward movement through the hub. The adjustable length infusion cannula also includes a locking mechanism configured to lock the cannula within the hub such that the first distal end extends a first distance past the second distal end of the hub.

A device suitable for dispensing a liquid substance, such as an ophthalmological substance, including a container; a dispenser for dispensing the substance and which includes a piston element, loaded by the pressure of the pressurized substance so as to adopt a standby position by default that prevents the preloading chamber from being flooded by a dose of the substance; and a valve element capable of enabling a connection between the preloading chamber and the outside. The device has an actuation mechanism that sequentially compresses a volume of air used for moving the piston element from the standby position thereof, allowing a dose of the substance to flood the preloading chamber to subsequently mechanically actuate the valve element and simultaneously enable the connection to the outside of the preloading chamber as well as of the volume of air previously used for moving the piston element from the standby position thereof.

A method of treating a subject with dry-form age-related macular degeneration (AMD) is disclosed. The method comprises administering into the subretina of the subject a therapeutically effective amount of a pharmaceutical composition comprising human RPE cells, wherein at least 95% of the cells thereof co-express premelanosome protein (PMEL17) and cellular retinaldehyde binding protein (CRALBP), and wherein the trans-epithelial electrical resistance of the cells is greater than 100 ohms to the subject, thereby treating the subject.