A transdermal therapeutic system for the transdermal administration of buprenorphine comprising a buprenorphine-containing self-adhesive layer structure having (A) a buprenorphine-impermeable backing layer, and (B) a buprenorphine-containing pressure-sensitive adhesive layer on the backing layer. The buprenorphine-containing adhesive layer comprises (a) at least one polymer-based pressure-sensitive adhesive, (b) an analgesically effective amount of buprenorphine base or a pharmaceutically acceptable salt thereof, (c) a viscosity-increasing substance in an amount of about 0.1% to about 8% of the buprenorphine-containing pressure-sensitive adhesive layer, and (d) a carboxylic acid selected from oleic acid, linoleic acid, linolenic acid, levulinic acid and mixtures thereof. The amount of the carboxylic acid is sufficient so that the analgesically effective amount of buprenorphine is solubilized in the carboxylic acid to form a mixture including the viscosity-increasing substance. This mixture forms dispersed deposits in the pressure-sensitive adhesive. The buprenorphine-containing pressure-sensitive adhesive layer is the skin contact layer.

A micro-negative pressure foam dressing and a manufacturing method thereof is disclosed, the dressing comprises a exothermic agent layer, an isolation component covering on the exothermic agent layer, an elastic memory piece disposed under the exothermic agent layer, a liquid absorbing negative pressure pad disposed under the elastic memory piece, a contact layer disposed under the liquid absorbing negative pressure pad, a sealing film disposed between the liquid absorbing negative pressure pad and the contact layer, and a bottom release film disposed under the contact layer; and in this invention, heat generated by a exothermic agent layer causes an elastic memory piece to expand downward to compress a foam layer, and after the heat dissipates completely, a micro-negative pressure is generated since a sealed environment is formed by a sealing film, a contact layer and a wound surface without a need for the VSD negative pressure technology.

Disclosed is a base plate for an ostomy appliance and a method for manufacturing a base plate. The base plate comprising: a top layer; a first adhesive layer; an electrode assembly comprising a plurality of electrodes, the electrode assembly having a first part and a second part, the first part comprising connection parts of the plurality of electrodes, the second part being arranged between the first adhesive layer and the top layer; and a monitor interface configured for connecting the base plate to a monitor device, the monitor interface comprising a plurality of terminals configured to form electrical connections with respective terminals of the monitor device. The top layer comprises a top layer opening configured to allow for connection between the plurality of electrodes of the electrode assembly and terminals of the monitor device.

Disclosed is a base plate for an ostomy appliance and a method for manufacturing a base plate. The base plate comprising: a top layer; a first adhesive layer; an electrode assembly comprising a plurality of electrodes, the electrode assembly having a first part and a second part, the first part comprising connection parts of the plurality of electrodes, the second part being arranged between the first adhesive layer and the top layer; and a monitor interface configured for connecting the base plate to a monitor device, the monitor interface comprising a plurality of terminals configured to form electrical connections with respective terminals of the monitor device. The top layer comprises a top layer opening configured to allow for connection between the plurality of electrodes of the electrode assembly and terminals of the monitor device.

The disclosed adhesive medical article has a backing layer having a first major surface and a second major surface opposite to the first major surface. The backing layer has a central portion and an outer circumferential portion. The article further has a pressure sensitive adhesive pattern coating applied onto at least part of the first major surface of the backing layer in such a way as to form a plurality of adhesive coated and adhesive uncoated areas of the backing layer. The adhesive uncoated areas comprise a central collection portion and at least one longitudinal extension radiating from the central collection portion towards the outer circumferential portion of the backing layer.

Dressings and kits for use in wound therapy and negative-pressure therapy comprising a manifold layer comprising porous open-cell liquid permeable foam and a polymer composition The polymer composition comprises a polymer and an active agent, such as collagen and oxidized regenerated cellulose. The foam may be felted. Methods of making and using the dressings are also provided.

Vacuum dressings with a guide tube are provided for implantable medical devices that inhibit infection associated with in-dwelling devices while encouraging healing of the incision around the device. The vacuum dressings mitigate pooling of fluids that harbor bacteria from between the outer diameter of an inserted implantable medical device and the inner diameter of a guide tube and also in the cylindrical gap, between the outer diameter of an inserted implantable medical device and the inner wall of the subcutaneous tunnel, which remains in fluid communication with skin microflora. Implantable medical devices may also illustratively include a variety of catheters, such as venous access, peritoneal dialysis, and other indwelling venous access catheters that require skin penetration; cannulas; Steinman pins; Kirschner wires; and cardiac assist device lines.

According to one aspect, a medical device may be configured to couple to a body. The medical device may comprise a material layer; a plurality of adhesive layers coupled to the material layer and configured to couple to a user's skin, wherein each adhesive layer of the plurality of adhesive layers includes a plurality of micro passages; a channel extending between two adjacent adhesive layers of the plurality of adhesive layers; and a superhydrophobic coating covering at least a portion of each of the two adjacent adhesive layers and the material layer forming the channel.

A cover layer for a vacuum wound therapy dressing includes a backing layer formed from a flexible polymeric membrane and an adhesive layer for affixing the backing layer over a wound bed to provide a substantially fluid-tight seal around a perimeter of the wound bed. The cover layer is reinforced with a reinforcement layer extending to a peripheral region of the backing layer to distribute forces associated with evacuating a reservoir, as defined by or within the cover, to stimulate healing of the wound bed.

This disclosure describes devices, systems, and methods related to oxygenated hemoglobin, the generation thereof, and the use thereof. An exemplary oxygenated hemoglobin therapy system includes an oxygen source configured to provide oxygen and a hemoglobin source configured to provide topical hemoglobin. The therapy system may also include a mixer which has a first inlet, a second inlet, and an outlet. The mixer is configured to mix the oxygen and the topical hemoglobin to form a mixture and to provide the mixture to a dressing via the outlet. The therapy system may further include the dressing. The oxygenated hemoglobin therapy systems described herein are suitable for use in medical devices, such as bandages, drapes, dressings, and wound closures.