Provided is a temperature-based dialysate regeneration device for regulating a temperature of dialysate discharged from a hemodialyzer to remove uremic toxins and waste therefrom, the temperature-based dialysate regeneration device including: a Joule-Thomson refrigerator, including a compressor, condenser, expander and evaporator, an adsorbent column, and a dialysate heat exchanger in which heat transfer occurs between dialysates. The refrigerant used for the JT refrigerator may be a mixture of two or more refrigerants to enhance the heat transfer generated by the latent heat in the evaporator and the condenser.

The invention discloses a freeze-dried powder of high molecular weight silk fibroin, preparation process and use thereof. The freeze-dried powder is obtained from silk by degumming, dissolution, dialysis, centrifugation, high temperature and high pressure treatment and freeze-drying. A method of preparing silk fibroin microspheres with polyethylene glycol comprises mixing a silk fibroin solution of 1-30 wt % with a PEG solution of 10-60 w % and incubating the resulting solution. A controlled-release or sustained-release silk fibroin gel formulation includes a gel-state carrier and a drug dispersed/adsorbed therein, the carrier is a silk fibroin gel formed by blending with LMW-PEG. The freeze-dried powder will not change the native molecular weight and random coil structure of silk fibroin, and can be rapidly dissolved into a solution, and can be stored and transported for a long time, and this reduces waste of silk fibroin materials and promotes R & D and biomedical applications of silk fibroin biomaterials.

A filter module of an extracorporeal blood treatment machine with a filter casing in which a hollow fiber bundle is attached whose hollow fibers comprise a hollow fibre wall made of a semi-permeable membrane, and whereby in their longitudinal extension the hollow fibers comprise a number of changes in their diameter. An amplitude of 0.1 to 1 mm is achieved for the exterior diameter of the respective hollow fiber starting from the hollow fiber's axis, whereby the periodicity provided in the axial direction of the hollow fiber is within a range of 1 to 10 cm and on the inside of the filter casing at least one radial constriction is configured or provided by which the fiber bundle is locally constricted.

Extracorporeal blood treatment apparatus and methods including a main treatment unit and an auxiliary treatment unit, along with one or more sensors for determining a parameter related to a pressure drop across the auxiliary treatment unit, and a control unit configured to control a flow regulator at least based on the parameter value.

Provided are a blood purifying filter and a blood purifying apparatus having the same. The blood purifying filter includes a plasma separation filter separating plasma from blood, a hemodialysis filter configured in parallel with the plasma separation filter to remove toxins and waste products from blood, a housing providing installation space for the plasma separation filter and the hemodialysis filter, and plasma inlet and outlet ports provided in the housing. The housing further includes a wall, a lower cap and an upper cap which are coupled to the plasma separation filter and the hemodialysis filter.

The invention relates to an ultrafiltration unit for continuous buffer or medium exchange, a method for continuous buffer or medium exchange in the ultrafiltration unit, and a plant in particular for (semi)continuous production of biopharmaceutical and biological macromolecular products in particular, such as proteins, e.g. monoclonal antibodies and vaccines, comprising the ultrafiltration unit according to the invention.

Systems, devices, and methods are provided for removing carbon dioxide from a target fluid, such as, for example, blood, to treat hypercarbic respiratory failure or another condition. A device is provided including first and second membrane components for removing dissolved gaseous carbon dioxide and bicarbonate from the fluid, which can be done simultaneously. The device can be in the form of a cartridge configured for use in a dialysis system. A method of treatment is also provided, involving drawing blood from a patient and bringing the patient's blood in contact with a first membrane component having a sweep gas passing therethrough, and a second membrane component having a dialysate passing therethrough. The dialysate's composition can be selected such that charge neutrality is maintained.

A porous membrane made from a poly(phenylene ether) copolymer has at least one of: a molecular weight cut off of less than 40 kilodaltons or a surface pore size of 0.001 to 0.1 micrometers. The porous membrane is made by dissolving the poly(phenylene ether) copolymer in a water-miscible polar aprotic solvent to form a porous membrane-forming composition; and phase-inverting the porous asymmetric membrane forming-composition in a first non-solvent composition to form the porous mem-brane. The porous membrane can be in the form of a sheet or a hollow fiber, and can be fabricated into separation modules.

A porous membrane made from a poly(phenylene ether) copolymer has at least one of: a molecular weight cut off of less than 40 kilodaltons or a surface pore size of 0.001 to 0.1 micrometers. The porous membrane is made by dissolving the poly(phenylene ether) copolymer in a water-miscible polar aprotic solvent to form a porous membrane-forming composition; and phase-inverting the porous asymmetric membrane forming-composition in a first non-solvent composition to form the porous membrane. The porous membrane can be in the form of a sheet or a hollow fiber, and can be fabricated into separation modules.

Articles, systems, and methods related to the separation of at least a first species from at least a second species using nanoporous membranes are generally described.