An integrated composite filter and a water purification system having the same are provided. The integrated composite filter includes: a shell defining a chamber therein, and defining a raw water inlet, a pretreated water outlet, a pretreated water inlet, a pure water outlet and a waste water outlet which are in communication with the chamber respectively; a pretreating filtering element disposed within the chamber; a filtering membrane disposed within the chamber. The pretreating filtering element and the filtering membrane are sequentially positioned between the raw water inlet and the pure water outlet as well as the waste water outlet, and the pretreating filtering element is positioned between the raw water inlet and the pretreated water outlet, and the filtering membrane is positioned between the pretreated water inlet and the pure water outlet as well as the waste water outlet.

An integrated composite filter and a water purification system having the same are provided. The integrated composite filter includes: a shell defining a chamber therein, and defining a raw water inlet, a pretreated water outlet, a pretreated water inlet, a pure water outlet and a waste water outlet which are in communication with the chamber respectively; a pretreating filtering element disposed within the chamber; a filtering membrane disposed within the chamber. The pretreating filtering element and the filtering membrane are sequentially positioned between the raw water inlet and the pure water outlet as well as the waste water outlet, and the pretreating filtering element is positioned between the raw water inlet and the pretreated water outlet, and the filtering membrane is positioned between the pretreated water inlet and the pure water outlet as well as the waste water outlet.

A cartridge is provided for dialysis or other blood processing therapy. In the cartridge, fibers may be substantially uniformly distributed near a midplane, but near an end, in the inter fiber space, there may be void flow channels, which may cause fluid flow in the inter fiber space to transition within a short region to uniform flow with minimal stagnation zones. Void flow channels may be be radially oriented, introducing fluid from the outer circumference, or axially oriented, introducing fluid along the axial direction through passageways through the potting material. The fluid flow in the inter fiber space may be perpendicular to the fibers, or radial with respect to a cartridge longitudinal axis. The cartridge may have blood flow in the inter fiber space, and flow of dialysate or ultrafiltrate in the lumens of the fibers, or the opposite situation.

A cartridge is provided for dialysis or other blood processing therapy. In the cartridge, fibers may be substantially uniformly distributed near a midplane, but near an end, in the inter fiber space, there may be void flow channels, which may cause fluid flow in the inter fiber space to transition within a short region to uniform flow with minimal stagnation zones. Void flow channels may be be radially oriented, introducing fluid from the outer circumference, or axially oriented, introducing fluid along the axial direction through passageways through the potting material. The fluid flow in the inter fiber space may be perpendicular to the fibers, or radial with respect to a cartridge longitudinal axis. The cartridge may have blood flow in the inter fiber space, and flow of dialysate or ultrafiltrate in the lumens of the fibers, or the opposite situation.

The invention relates to a filter device for the exchange of substances, comprising a pipe section-shaped housing with a center of gravity and with two housing ends, in which housing a hollow fiber bundle consisting of semi-permeable membranes is arranged, comprising, furthermore, an end cap having a first and second opening, wherein the housing and the end cap configure a first sealing surface which connects the housing and the end cap sealingly, and wherein the first sealing surface is spaced apart further from the center of gravity of the housing than the aperture, and wherein a first fluid chamber is formed between the first sealing surface and the first opening of the end cap, via which first fluid chamber the first opening is connected to the first flow chamber, wherein the housing and the one end cap configure a second sealing surface, wherein the first and second sealing surface are not configured by way of a sealant.

The invention relates to a filter device for the exchange of substances, comprising a pipe section-shaped housing with a center of gravity and with two housing ends, in which housing a hollow fiber bundle consisting of semi-permeable membranes is arranged, comprising, furthermore, an end cap having a first and second opening, wherein the housing and the end cap configure a first sealing surface which connects the housing and the end cap sealingly, and wherein the first sealing surface is spaced apart further from the center of gravity of the housing than the aperture, and wherein a first fluid chamber is formed between the first sealing surface and the first opening of the end cap, via which first fluid chamber the first opening is connected to the first flow chamber, wherein the housing and the one end cap configure a second sealing surface, wherein the first and second sealing surface are not configured by way of a sealant.

An extracorporeal blood treatment machine for carrying out a blood treatment including a machine front on which a hollow fiber filter module is arranged in a horizontal position, which hollow fiber filter module includes a cylindrical housing, a blood chamber having a blood inlet nozzle and a blood outlet nozzle and a solution chamber having a solution inlet nozzle extending transversely to the longitudinal direction of the hollow fiber filter module and a solution outlet nozzle extending transversely to the longitudinal direction of the hollow fiber filter module, the solution chamber being semi-permeably communicated at least in portions with the blood chamber, wherein a height potential is present in the horizontal position between the solution inlet nozzle and the solution outlet nozzle so that drainage of solution is enabled via one of the solution nozzles and evacuation of air bubbles is enabled via an other of the solution nozzles.

A microfluidic device for increasing convective clearance of particles from a fluid is provided. In some implementations, described herein the microfluidic device includes multiple layers that each define infusate, blood, and filtrate channels. Each of the channels have a pressure profile. The device can also include one or more pressure control features. The pressure control feature controls a difference between the pressure profiles along a length of the device. For example, the pressure control feature can control the difference between the pressure profile of the filtrate channel and the pressure profile of the blood channel. In some implementations, the pressure control feature controls the pressure difference between two channels such that the difference varies along the length of the channels by less than 50% of the pressure difference between the channels at the channels' inlets.

A dialysis and/or isotope exchange device includes a support, a sample chamber having a thickness of between 25 m and 500 m, and a container including a semipermeable membrane in contact with the sample chamber. Dialysis and/or isotope exchange takes less than 100,000 seconds for a concentration of a substance to reach a target concentration.

A dialysis and/or isotope exchange device includes a support, a sample chamber having a thickness of between 25 m and 500 m, and a container including a semipermeable membrane in contact with the sample chamber. Dialysis and/or isotope exchange takes less than 100,000 seconds for a concentration of a substance to reach a target concentration.