A sterile solution product bag includes sterilization grade filter integrated directly into the product bag such that microbial and particulate matter filtration can be performed using the filter directly at the point of fill. The filter can include a hollow fiber filter membrane contained in a stem connected to a bladder of the product bag.

An external circulation-type hollow fiber membrane module which has a high processing capacity and which is capable of inhibiting a to-be-treated liquid within a case from flowing through a short path and efficiently bringing the liquid into contact with a hollow fiber membrane in whichever direction of a vertical direction, a horizontal direction, etc., the liquid flows. An external circulation-type hollow fiber membrane module is provided with: a hollow fiber membrane bundle; a case; and a short-path prevention body that blocks flowing of a to-be-treated liquid in a gap between the hollow fiber membrane bundle and the case, wherein a first end of the hollow fiber membrane bundle is fixed in the case, and the short-path prevention body is provided to the downstream side of a first port which is a liquid flow-in port in the case so as to project from the inner surface of the case.

A sterile solution product bag includes sterilization grade filter integrated directly into the product bag such that microbial and particulate matter filtration can be performed using the filter directly at the point of fill. The filter can include a hollow fiber filter membrane contained in a stem connected to a bladder of the product bag.

A membrane contactor includes: a cap has an internally beveled surface and a cap port; a cup body has an externally beveled surface in sealing engagement with the internally beveled surface, a side port on a side of the cup body and an end port located on an end of the cup body; and a membrane cartridge is located within the cup body, is sealed to an open end of the cup body, and is in sealed fluid communication with the end port. A method of making a membrane contactor includes the steps of: sealingly mating a perforated center of a membrane contactor with the end port of a cup body; sealingly joining an end of the membrane cartridge adjacent an open end of the cup body; and sealingly joining a beveled surface of the cap to a beveled external surface of the cup body.

The present invention provides an intrinsically anti-microbial hollow fiber membrane for filtration of liquids. The membrane comprises a plurality of porous hollow bilayer membrane fibers wherein the liquid enters from outside of the fiber, passing through the porous membrane into the lumen of the fiber and coming out from the hollow ending of the fiber, wherein this configuration provides a liquid outside-in arrangement and retains the filtrate outside. It means that membrane of the invention has built in characteristics to act against microbes in order to provide the use with a safe liquid free from microbes. The outer side or outer wall of the hollow fibers may be configured to become hydrophobic whereas inner side or inner wall of the hollow fiber membrane may be configured to become hydrophilic to enhance the water permeability to a great extent. The hollow fiber membrane may be configured to give it an intrinsic anti-microbial capability. A device containing above said membrane has also been disclosed.

A method of cleaning a membrane surface immersed in a liquid medium with a fluid flow, including the steps of providing a randomly generated intermittent or pulsed fluid flow along the membrane surface to dislodge fouling materials therefrom. A membrane module is also disclosed comprising a plurality of porous membranes (6) or a set of membrane modules (5) and a device (11) for providing a generally randomly generated, pulsed fluid flow such that, in use, said fluid flow moves past the surfaces of said membranes (6) to dislodge fouling materials therefrom.

Disclosed herein is a hollow fiber membrane module provided with a hollow fiber membrane bundle, a case in which the hollow fiber membrane bundle is contained, a fixation part which affixes the hollow fiber membrane bundle within the case and divides the space inside the case into a first space that is outside the hollow fiber membranes and a second space that is in communication with the insides of the hollow fiber membranes, and a partition plate which divides the first space into a first region and a second region.

In embodiments of the invention, there is provided a dialyzer or filter comprising hollow fibers, in which blood flows on the exterior of the hollow fibers, and dialysate or filtrate may flow on the inside. The external surfaces of the hollow fibers may have properties of smoothness and hemocompatibility. The fiber bundle may have appropriate packing fraction and may have wavy fibers. Optimum shear rates and blood velocities are identified. Geometric features of the cartridge, such as pertaining to flow distribution of the blood, may be different for different ends of the cartridge. Air bleed and emboli traps may be provided. Lengthened service life may be achieved by combinations of these features, which may permit additional therapies and applications or better economics.

The present disclosure relates to a filtration device comprising a plurality of hollow fiber membranes, a process for its production, and its use for the dead-end filtration of infusion liquids.

Provided is a cartridge-type hollow fiber membrane module including a hollow fiber membrane unit module with a free end and a cartridge frame and a submerged water treatment apparatus including an air diffuser apparatus capable of intermittent and continuous aeration disposed below the hollow fiber membrane module, wherein the cartridge-type membrane module with the free end using the coarse bubble generating air diffuser apparatus capable of intermittent/continuous aeration in conjunction with an air accumulation pipe may control aeration/non-aeration cycles through adjustment of the volume of an air chamber and an amount of inflow air and carry out continuous aeration based on changes in raw water load and a concentration of solids in a membrane separation tank.