A natural gas stream is passed through a single membrane element that is fabricated with two or more distinct types of membrane fibers. The membrane fibers have different characteristics in order to reduce the number of membrane elements required for gas separation and to improve gas separation performance due to changing gas composition because of permeation as the gas travels through the membrane element.

A method for potting hollow fiber membranes comprises the steps of forming a bundle of membranes with a layer of adhesive; covering one end of the bundle with a permeate pan, the ends of the membranes protruding upwards into the permeate pan; and flowing a liquid potting material into the permeate pan. The bundle may be tilted to more quickly distribute the liquid potting material. An apparatus for filtering liquid with hollow fiber membranes comprises a bundle of membranes, a layer of adhesive spaced from the end of the bundle, a permeate pan covering the end of the bundle, and a header formed with the membranes, the adhesive and the pan.

The present invention provides a method that allows the preparation of a cell concentrate in a short time without loss of cells and great damage on cells by simple operations. The present invention provides a method for producing a cell concentrate using an inside-out filtration system for processing a cell suspension, the system including: a cell suspension inlet port; a filtrate outlet port; a cell suspension outlet port; and a hollow fiber separation membrane interposed between the cell suspension inlet port and the cell suspension outlet port, wherein the hollow fiber separation membrane is provided with inner pores with an average pore size of 0.1 m to 10 m, and the quotient of the division of an initial filtrate flow rate by a linear velocity of the cell suspension flowing through the hollow fibers is 2.5 or less.

Systems, devices, and methods are provided for removing carbon dioxide from a target fluid, such as, for example, blood, to treat hypercarbic respiratory failure or another condition. A device is provided including first and second membrane components for removing dissolved gaseous carbon dioxide and bicarbonate from the fluid, which can be done simultaneously. The device can be in the form of a cartridge configured for use in a dialysis system. A method of treatment is also provided, involving drawing blood from a patient and bringing the patient's blood in contact with a first membrane component having a sweep gas passing therethrough, and a second membrane component having a dialysate passing therethrough. The dialysate's composition can be selected such that charge neutrality is maintained.

The invention relates to a blood treatment device configured to dephosphorylate extracellular adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and/or lipopolysaccharide (LPS) in the blood of a patient in need thereof in an extracorporeal blood circuit, wherein the device comprises a matrix having alkaline phosphatase (AP) immobilized thereon. The invention further relates to an extracorporeal blood circuit comprising a blood treatment device of the invention and to the blood treatment device for use as a medicament or to methods of treating an infection, preferably a blood or systemic infection, such as sepsis, and/or for the treatment of sepsis-associated acute kidney injury (AKI).

An array of hollow fibers including a plurality of hollow fibers of a predetermined diameter configured to receive a gas having oxygen therein and transfer the oxygen to a fluid and/or transfer carbon dioxide in the fluid to a gas. The array is configured in a predetermined pattern having a predetermined packing density that is a fraction of a total cross-sectional area of the array occupied by the hollow fibers.

A method for potting hollow fiber membranes comprises the steps of forming a bundle of membranes with a layer of adhesive; covering one end of the bundle with a permeate pan, the ends of the membranes protruding upwards into the permeate pan; and flowing a liquid potting material into the permeate pan. The bundle may be tilted to more quickly distribute the liquid potting material. An apparatus for filtering liquid with hollow fiber membranes comprises a bundle of membranes, a layer of adhesive spaced from the end of the bundle, a permeate pan covering the end of the bundle, and a header formed with the membranes, the adhesive and the pan.

Installation for the pressurised filtration of liquid with a view to producing drinking water, comprising at least one membrane-based drinking-water production unit (MPU), each MPU comprising: a plurality of filtration blocks each containing a bundle of pressure tubes mounted in parallel, each pressure tube accommodating at least two membrane-based filtration modules with spiral membranes or hollow-fibre membranes mounted in series, means (20) for feeding the liquid that is to be filtered, means for removing the filtered liquid, and means (30) for removing the concentrate, characterised in that the membranes of the filtration modules are of at least two different types selected from the group consisting of reverse-osmosis membranes and low-pressure reverse-osmosis membranes (4-6), on the one hand, and nanofiltration membranes (1-3) on the other hand, and in that at least one MPU comprises means (21-26) making it possible to alter the order in which the blocks of pressure tubes that it groups together are supplied with fluid. The method consists in supplying the filtration blocks of at least one MPU in a first order of supply in which the tubes containing nanofiltration membranes are at the head of the MPU and then in supplying the pressure tubes in a second order of supply in which the pressure tubes containing reverse-osmosis membranes or low-pressure reverse-osmosis membranes are at the head of the MPU.

A cover member (36) that forms an end of a housing (26) of an oxygenator (10) has a recessed wall portion (88) recessed relative to a cover main body (74) further toward a side of a gas exchange unit (30) than an inner surface (74a). A pressure control hole (86) is formed through a main body (74) of the cover member (36), and a sampling port (90a) is disposed in the second recessed wall portion (88) to collect gas guided out from the gas exchange unit (30). The sampling port (90a) faces, at its inner opening portion (92), a second outlet side end face (31b) of the gas exchange unit (30).

The disclosure relates to devices and methods for extracorporeal conditioning of blood. Extracorporeal blood oxygenators and blood oxygenator components, such as conditioning modules, are described. An extracorporeal blood oxygenator includes a conditioning module having an external frame, an inlet cover, an outlet cover, and an internal chamber. A fiber assembly is disposed within the internal chamber and a potting material on the fiber assembly creates a circumferential seal that defines a passageway through the fiber assembly having a substantially circular cross-sectional shape. A fluid inlet is in fluid communication with the passageway, has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly, and has an internal curvilinear surface adjacent the fiber assembly. A fluid outlet on the opposite side of the fiber assembly also has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly.