A humidification and selective permeation module in which humidification of a gaseous feed stream and selective permeation of components in the gaseous feed stream using a facilitated-transport membrane occurs within the same unit operation is disclosed. A process for separation of components in a gaseous feed stream using the humidification and permeation module combines continuous humidification of the feed stream and selective permeation using the facilitated-transport membrane.

The disclosure relates to devices and methods for extracorporeal conditioning of blood. Extracorporeal blood oxygenators and blood oxygenator components, such as conditioning modules, are described. An extracorporeal blood oxygenator includes a conditioning module having an external frame, an inlet cover, an outlet cover, and an internal chamber. A fiber assembly is disposed within the internal chamber and a potting material on the fiber assembly creates a circumferential seal that defines a passageway through the fiber assembly having a substantially circular cross-sectional shape. A fluid inlet is in fluid communication with the passageway, has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly, and has an internal curvilinear surface adjacent the fiber assembly. A fluid outlet on the opposite side of the fiber assembly also has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly.

An inventive drug product filling device for filling a liquid drug product into containers is disclosed. The drug filling device includes a drug product preparer configured for preparing the liquid drug product and a filling station configured for filling the liquid drug product into the containers. The filling station is fluidly coupled to the drug product preparer. A degasser is fluidly interposed between the drug product preparer and the filling station. The degasser has a membrane configured for at least partially separating off gas from the liquid drug product. Methods of (i) filling a liquid drug product into containers, (ii) increasing the accuracy of the filling weight of a liquid drug product in a container, (iii) increasing the stability oxygen-sensitive active pharmaceutical ingredient in a liquid drug product, and (iv) reducing polysorbate aggregate formation in a liquid drug product are also disclosed.

The disclosure relates to devices and methods for extracorporeal conditioning of blood. Extracorporeal blood oxygenators and blood oxygenator components, such as conditioning modules, are described. An extracorporeal blood oxygenator includes a conditioning module having an external frame, an inlet cover, an outlet cover, and an internal chamber. A fiber assembly is disposed within the internal chamber and a potting material on the fiber assembly creates a circumferential seal that defines a passageway through the fiber assembly having a substantially circular cross-sectional shape. A fluid inlet is in fluid communication with the passageway, has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly, and has an internal curvilinear surface adjacent the fiber assembly. A fluid outlet on the opposite side of the fiber assembly also has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly.

An oxygenator having a plurality of porous hollow fiber membranes for gas exchange to treat blood is manufactured by dissolving a silicone compound in an organic solvent having a surface tension of less than 70 dyn/cm to prepare a coating solution, and bringing an inner surface of the hollow fiber membranes into contact with the coating solution under a negative pressure of 50 hPa or more and 150 hPa or less to form a silicone compound-containing coating layer on the inner surface. An antithrombotic polymer compound-containing coat can be provided directly on an outer surface of the hollow fiber membranes.

The disclosure relates to devices and methods for extracorporeal conditioning of blood. Extracorporeal blood oxygenators and blood oxygenator components, such as conditioning modules, are described. An extracorporeal blood oxygenator includes a conditioning module having an external frame, an inlet cover, an outlet cover, and an internal chamber. A fiber assembly is disposed within the internal chamber and a potting material on the fiber assembly creates a circumferential seal that defines a passageway through the fiber assembly having a substantially circular cross-sectional shape. A fluid inlet is in fluid communication with the passageway, has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly, and has an internal curvilinear surface adjacent the fiber assembly. A fluid outlet on the opposite side of the fiber assembly also has a lumen that extends along an axis that is substantially perpendicular to the fiber assembly.

An oxygenator having a plurality of porous hollow fiber membranes for gas exchange to treat blood is manufactured by dissolving a silicone compound in an organic solvent having a surface tension of less than 70 dyn/cm to prepare a coating solution, and bringing an inner surface of the hollow fiber membranes into contact with the coating solution under a negative pressure of 50 hPa or more and 150 hPa or less to form a silicone compound-containing coating layer on the inner surface. An antithrombotic polymer compound-containing coat can be provided directly on an outer surface of the hollow fiber membranes.

The present invention relates to a cartridge of a humidifier for a fuel cell for humidifying dry gas supplied from the outside by using wet gas discharged from a fuel cell stack, and a humidifier for a fuel cell, the cartridge including: an inner case having openings at each end thereof and containing a plurality of hollow fiber membranes; a gas inlet and a gas outlet formed in the inner case; and an adjustment cover movably coupled to the inner case, and adjusting at least one of an inflow area through which the wet gas or the dry gas flows through the gas inlet, and an outflow area through which the wet gas or the dry gas flows out through the gas outlet.

Proposed are a fuel cell membrane humidifier and a fuel cell system having the same in which humidification by moisture exchange and cooling by heat exchange are performed in one membrane humidifier such that the fuel cell system can be simplified and be miniaturized. The fuel cell membrane humidifier includes a housing part having a space divided by a partition, a humidification module formed in a first portion of the divided space and having a plurality of hollow fiber membranes allowing a first fluid flowing thereinside to perform moisture exchange with a second fluid flowing thereoutside, a heat exchange module formed in a second portion of the divided space and configured to cool a first fluid flowing inside the heat exchange module, and a flow control part configured to actively control a flow direction of the first fluid.

The present disclosure provides a fuel cell humidifying system for supplying humidified air to the fuel cell, and The fuel cell humidifying system according to an embodiment of the present disclosure includes: a plurality of humidifying modules configured to humidify battery gas to be supplied to a fuel cell stack by using wet gas; a humidifier configured to supply wet gas to the humidifying modules and discharge the wet gas discharged from the humidifying modules; a supply cap coupled to one side of the wet part to supply the battery gas to the humidifying modules; and a discharge cap coupled to the other side of the wet part to discharge the battery gas discharged from the humidifying modules to the fuel cell stack, and each of the humidifying modules comprises a cartridge coupled to a plurality of hollow fiber membranes, a mid-case coupled to one or more cartridges, a supply hole formed through the mid-case so that wet gas is supplied into the mid-case, and a discharge hole formed through the mid-case so that the wet gas is discharged the mid-case, and the wet part comprises a wet body for accommodating the humidifying modules therein, a supply member for supplying the wet gas to the wet body, and a discharge member for discharging the wet gas from the wet body.