Aspects of the present disclosure relate to filtration systems and methods for production of biologically-produced products, which may include pharmaceutical and/or protein products. Certain biomanufacturing systems described herein comprise a bioreactor (e.g., a perfusion bioreactor, a chemostat) and a filter probe comprising a filter bundle comprising a plurality of hollow fibers (e.g., longitudinally aligned hollow fibers). According to some embodiments, a center-to-center distance between any two hollow fibers within the fiber bundle at one or more points along a length of the fiber bundle is relatively large (e.g., greater than or equal to an average outer diameter of the hollow fibers of the fiber bundle, greater than or equal to 1.1 times a minimum diameter of the two hollow fibers). In some embodiments, the hollow fibers within the fiber bundle are arranged in an array (e.g., a hexagonal, linear, annular, or square array).

An apparatus for removing water vapor from a feed gas is provided that comprises a membrane housing, a membrane that divides a first pressure side and a second pressure side of the membrane housing, a feed gas inlet and outlet on the first pressure side, a sweep gas inlet and outlet on the second pressure side, a sweep gas flow regulator, and a pump. In some embodiments the feed gas can be at ambient pressure and a pressure drop across the membrane can be less than about 1 atm.

Disclosed herein is a perfusion filtration module or bioreactor for filtering a fluid, wherein the filtration module or bioreactor has a plurality of hollow fiber filter membranes that are splayed to reduce fouling of the filtration array.

A device for mass transfer between blood and a transfer medium, in particular a gas/gas mixture, includes a chamber through which blood can flow and in which a plurality of mass-permeable hollow fibers of at least one hollow fiber mat, in which the hollow fibers are held at a spacing by way of warp threads, are disposed in the form of a wound or folded hollow fiber package, wherein a transfer medium is able to flow through, and blood is able to flow around, the hollow fibers, and wherein the density of hollow fibers varies locally in the hollow fiber package in the cross-section perpendicular to length of the hollow fibers. Hollow fiber packages and methods of manufacturing thereof are provided in which the hollow fibers are held at a spacing by warp threads, in which the spacing between adjoining hollow fibers is locally increased, in particular compared to a predominantly equidistant spacing between the hollow fibers.

Membrane oxygenators useful in a variety of medical situations, including various short-term procedures and relatively longer-term life support, and components of membrane-based oxygenators, such as conditioning modules for exchanging oxygen for carbon dioxide during extracorporeal conditioning of blood, are described. A conditioning module includes a plurality of mats of hollow fibers and a potting material disposed throughout the peripheral edges of the mats to create a circumferential seal that defines a passageway through the plurality of fiber mats having a substantially circular cross-sectional shape. The circumferential seal defines an effective fiber length for each of the hollow fibers. A resisting member is disposed across the proximal ends of at least some of the hollow fibers and is adapted to resist fluid flow into each of the hollow fibers based on the effective fiber length of the particular hollow fiber.

A portable water filtration device is provided. The portable water filtration device comprises a housing defining an interior volume, said housing comprising; an input port for receiving water under pressure from an external source, and; an output port having an open position and a closed position. The device further comprises; a filter comprising an an array of hydrophilic capillary fibre membranes, said filter being positioned within the housing so as to form a fluid path between the interior volume of the housing and the output port such that, in use, when the output port is in the open position, water received at the input port flows under a pressure differential induced by the external source through walls of the capillary fibre membranes to respective open ends of the capillary fibre membranes to the output port, and further wherein; the filter fills at least 65% of the interior volume of the housing.

A hollow fiber membrane bundle with a longitudinal extent, with a membrane bundle cross section and with a first and a second bundle end, comprising a multitude of hollow fiber membranes extending between the first and the second bundle end, and also comprising, within the membrane bundle cross section, a proportion of threads which are arranged between the hollow fiber membranes and which keep the hollow fiber membranes apart. The arrangement of the threads between the hollow fiber membranes is such that at the first bundle end and/or at the second bundle end the hollow fiber membranes protrude beyond at least some of the threads, such that the hollow fiber membrane bundle has a smaller proportion of threads in a first and/or second end region, extending from the first and/or the second bundle end, than in a bundle region, located between the first and the second bundle end, which has a maximal proportion of threads, the length of the first end region and/or the length of the second end region being 1% to 45% of the bundle length.

A membrane module with a cylindrical housing with a longitudinal extent and with a first and a second housing end, and with a housing shell extending between the first and the second housing end, and also with a housing inner wall, where a hollow fiber membrane bundle of the above type is arranged in the housing oriented in the direction of the longitudinal extent of the housing.

Systems, devices, and methods are provided for removing carbon dioxide from a target fluid, such as, for example, blood, to treat hypercarbic respiratory failure or another condition. A device is provided including first and second membrane components for removing dissolved gaseous carbon dioxide and bicarbonate from the fluid, which can be done simultaneously. The device can be in the form of a cartridge configured for use in a dialysis system. A method of treatment is also provided, involving drawing blood from a patient and bringing the patient's blood in contact with a first membrane component having a sweep gas passing therethrough, and a second membrane component having a dialysate passing therethrough. The dialysate's composition can be selected such that charge neutrality is maintained.

The present invention relates to a hollow fiber membrane module provided with: a tubular casing having a first end and a second end in the axial direction; a plurality of hollow fiber membranes; a first potting part; and a second potting part, the hollow fiber membrane module further having a flow regulation structure in which a fluid flowing outside the hollow fiber membranes from the second end side toward the first end side forms a flow directed to the radial center on the second end side of the first potting part, and further forms a radial flow directed from the radial center to the radially outer peripheral side on the second end side of the first potting part.

This hollow fiber membrane module is provided with: a cylindrical case having a first end and a second end in the direction of height; a plurality of hollow fiber membranes accommodated in the cylindrical case; and a first potting unit attaching the end parts of the plurality of hollow fiber membranes positioned at the first end of the cylindrical case while the end parts are open. The hollow fiber membranes have a rupture strength of 23 MPa or more. The filling rate for the hollow fiber membranes is 40-80%.