A hollow fiber membrane module includes: a tubular container accommodating a hollow fiber membrane bundle; headers, and potted parts. The header includes a header protrusion that protrudes in an annular shape toward the tubular container. The tubular container includes double annular protrusions, which are an inner protrusion and an outer protrusion protruding toward the header. The header and the tubular container are welded together by ultrasonic welding, with the header protrusion being inserted between the inner protrusion and the outer protrusion of the tubular container. The header protrusion and the inner protrusion of the tubular container are welded together at least in one or more regions, and the header protrusion and the outer protrusion of the tubular container are welded together at least in one or more regions.

An external-pressure type hollow fiber membrane module in which fouling is not likely to occur in a hollow fiber membrane at the time of filtering operation, and which exhibits excellent washability of the hollow fiber membrane is provided. The first end side and the second end side of a plurality of hollow fiber membrane bundles 60 are fixed with adhesive, together with an inner wall surface of the tubular housing 10 or an inner wall surface of the cap. The adhesive-fixed part of the first end side includes a plurality of raw water introduction holes 65 which are formed therethrough in a thickness direction. An external-pressure type hollow fiber membrane module in which the plurality of raw water introduction holes 65 include first group raw water introduction holes 66 formed at positions including central parts of the plurality of hollow fiber membrane bundles 60, respectively, and second group raw water introduction holes 67 formed between the plurality of hollow fiber membrane bundles 60 and between the plurality of hollow fiber membrane bundles 60 and the inner wall surface of the tubular housing 10.

Aspects of the present disclosure relate to filtration systems and methods for production of biologically-produced products, which may include pharmaceutical and/or protein products. Certain biomanufacturing systems described herein comprise a bioreactor (e.g., a perfusion bioreactor, a chemostat) and a filter probe comprising a filter bundle comprising a plurality of hollow fibers (e.g., longitudinally aligned hollow fibers). According to some embodiments, a center-to-center distance between any two hollow fibers within the fiber bundle at one or more points along a length of the fiber bundle is relatively large (e.g., greater than or equal to an average outer diameter of the hollow fibers of the fiber bundle, greater than or equal to 1.1 times a minimum diameter of the two hollow fibers). In some embodiments, the hollow fibers within the fiber bundle are arranged in an array (e.g., a hexagonal, linear, annular, or square array).

An object of the present invention is to provide a filter unit in which hollow fiber membranes can be effectively cleaned. A filter unit of the present invention includes a plurality of filtration modules and one or more air bubble generation modules that supply bubbles to the filtration modules from below. Each filtration modules includes a plurality of hollow fiber membranes extending in an up-down direction and arranged side by side in a curtain shape and which are arranged at intervals. The one or more air bubble generation modules supply coarse bubbles to the filtration modules.

A filtration device includes features for robust filtering capability. In particular, the filtration device includes a filter medium having mixed matrix membranes that include hollow fiber membranes embedded with adsorbents such that the filter medium provides both mechanical and adsorption capability.

A sterile solution product bag includes sterilization grade filter integrated directly into the product bag such that microbial and particulate matter filtration can be performed using the filter directly at the point of fill. The filter can include a hollow fiber filter membrane contained in a stem connected to a bladder of the product bag.

A hollow fiber module (1, 1) is made by inserting a bundle of hollow fibers (3) into a housing (2, 2) that has an end closed by a cap (17). A fluid first component (27) that can assume a solid state is introduced into a space adjacent the cap (17) and forms a spacer into which ends of the hollow fibers (6, 7) project. A fluid curable second component (4) is introduced before the first component (27) via a second inflow (28) and is cured to form a sealing layer (9) that embeds the bundle of hollow fibers (3) and seals it with respect to the adjacent housing wall (29, 29). The cap (17) is removed from the module housing (2, 2) along with the first component (27) and ends of the hollow fibers (6) embedded in the first component (27).

The present disclosure relates to an external pressure type hollow fiber membrane component, a filtration membrane component, and a membrane filtration assembly, and provides an external pressure type hollow fiber membrane component, comprising: a housing having an inner cavity; and two end parts respectively provided at two ends of the inner cavity of the housing, the end parts being provided with a plurality of void passages running through the end parts in the axial direction of the housing and a plurality of water collection passages communicated with each other, and the void passages and the water collection passages are staggered at intervals. The present disclosure also provides a filtration membrane component and a membrane filtration assembly.

The present invention relates to a cartridge for a fuel cell humidifier, and a fuel cell humidifier, the cartridge comprising: an inner case having both ends opened; a hollow fiber membrane bundle received in the inner case; an inner inlet and an inner outlet formed on the inner case so as to be spaced along a first axial direction; a first potting layer for fixing one end of the hollow fiber membrane bundle at one end of the inner case; and a second potting layer for fixing the other end of the hollow fiber membrane bundle at the other end of the inner case, wherein the packing density is 0.405 to 0.625 inclusive, the packing density being based on, with respect to a second axial direction perpendicular to the first axial direction, the potting cross-section of the inside of the one end of the inner case where the first potting layer is potted, and the membrane cross-section of the hollow fiber membrane bundle.

The present invention relates to a fuel cell membrane humidifier capable of preventing a decrease in humidification efficiency, caused by a pressure difference between the inside and outside of the membrane humidifier. The fuel cell membrane humidifier according to an embodiment of the present invention comprises: a middle case which has a module insertion unit; a cap case; a hollow fiber membrane module which is inserted into the module insertion unit; and an active pressure buffer unit which is formed between the middle case and the module insertion unit and which, according to the output condition of a fuel cell, prevents expansion of the module insertion unit due to the pressure difference between the inside and outside of the middle case or eliminates the pressure difference.