A hollow fiber membrane module that increases a ratio of a membrane area contributing to membrane separation effect. On an inner wall surface of a case 100, at least one flow-straightening projection 130 and at least one flow-disturbing projection 140 are provided. The flow-straightening projection 130 projects toward an outer circumferential surface of a hollow fiber membrane bundle 300 to secure a gap between the inner wall surface of the case 100 and the hollow fiber membrane bundle 300 and extends from one end side toward the other end side of the case 100 and straightens a flow of fluid. The flow-disturbing projection 140 extends along a circumferential direction of the case 100 and disturbs the flow of the fluid.

A hollow fiber porous membrane includes polyethersulfone or polysulfone. The hollow fiber porous membrane has an inner diameter from 300 to 600 μm, a thickness from 70 to 200 μm, a molecular weight cut-off of 10000 or lower, and a plurality of pores having a pore diameter from 0.1 to 0.5 μm throughout an outer surface; and a swelling rate of less than 5% as defined below: Swelling Rate (%): for 20 or more of the hollow fiber porous membranes, after a membrane thickness in a cross section of each one of the hollow fiber porous membranes in the width direction is measured at randomly selected 10 or more locations, an average membrane thickness is calculated based on 200 or more locations in total, and the swelling rate is calculated by a formula below: Swelling Rate (%)=(location numbers where the membrane thickness as measured exceeded 1.3 times the average membrane thickness)/(membrane thickness measurement numbers)×100.

A hollow fiber porous membrane includes polyethersulfone or polysulfone. The hollow fiber porous membrane has an inner diameter from 300 to 600 μm, a thickness from 70 to 200 μm, a molecular weight cut-off of 10000 or lower, and a plurality of pores having a pore diameter from 0.1 to 0.5 μm throughout an outer surface; and a swelling rate of less than 5% as defined below: Swelling Rate (%): for 20 or more of the hollow fiber porous membranes, after a membrane thickness in a cross section of each one of the hollow fiber porous membranes in the width direction is measured at randomly selected 10 or more locations, an average membrane thickness is calculated based on 200 or more locations in total, and the swelling rate is calculated by a formula below: Swelling Rate (%)=(location numbers where the membrane thickness as measured exceeded 1.3 times the average membrane thickness)/(membrane thickness measurement numbers)×100.

Provided is a membrane distillation module 100 comprising a membrane distillation membrane cartridge 10 and a membrane distillation housing 20, wherein: the membrane cartridge 10 comprises a membrane anchoring part 12 in which porous membranes 11 are anchored by anchoring resin; the housing 20 comprises a housing body 30 and a housing lid 40; the membrane distillation module 100 comprises a support part 60 where the outer surface of the membrane anchoring part 12 is supported by the inner surface of the housing 20 with a seal member 50 interposed therebetween; and a value C in the cross section of the support part 60 is at least 30° C. as represented by the following formula, where d.sub.F is the equivalent circular diameter (mm) of the outer circumference of the membrane anchoring part 12, k.sub.F is the linear expansion coefficient (1/° C.) of the anchoring resin, d.sub.E is the equivalent circular diameter (mm) of the inner circumference of the housing 20; and k.sub.E is the linear expansion coefficient (1/° C.) of a portion where the housing 20 contacts the seal member 50.

Provided is a membrane distillation module 100 comprising a membrane distillation membrane cartridge 10 and a membrane distillation housing 20, wherein: the membrane cartridge 10 comprises a membrane anchoring part 12 in which porous membranes 11 are anchored by anchoring resin; the housing 20 comprises a housing body 30 and a housing lid 40; the membrane distillation module 100 comprises a support part 60 where the outer surface of the membrane anchoring part 12 is supported by the inner surface of the housing 20 with a seal member 50 interposed therebetween; and a value C in the cross section of the support part 60 is at least 30° C. as represented by the following formula, where d.sub.F is the equivalent circular diameter (mm) of the outer circumference of the membrane anchoring part 12, k.sub.F is the linear expansion coefficient (1/° C.) of the anchoring resin, d.sub.E is the equivalent circular diameter (mm) of the inner circumference of the housing 20; and k.sub.E is the linear expansion coefficient (1/° C.) of a portion where the housing 20 contacts the seal member 50.

Hollow fiber membranes in an oxygenator for an extracorporeal blood circulator are coated with an antithrombotic polymeric material. The porous hollow fiber membranes for gas exchange have outer surfaces, inner surfaces forming lumens, opening portions through which the outer surfaces communicate with the inner surfaces in a housing. A blood flow path is outside of the hollow fiber membrane bundle in the housing, between a blood inlet port and a blood outlet port. The coating is obtained by filling the blood flow path with a colloidal solution containing an antithrombotic polymeric compound, and moving the colloid solution between the blood inlet port and the blood outlet port for a time that coats a predetermined amount of antithrombotic polymeric compound on the outer surfaces of the hollow fiber membranes. Other surfaces within the oxygenator contacting the blood flow likewise receive the coating.

Hollow fiber membranes in an oxygenator for an extracorporeal blood circulator are coated with an antithrombotic polymeric material. The porous hollow fiber membranes for gas exchange have outer surfaces, inner surfaces forming lumens, opening portions through which the outer surfaces communicate with the inner surfaces in a housing. A blood flow path is outside of the hollow fiber membrane bundle in the housing, between a blood inlet port and a blood outlet port. The coating is obtained by filling the blood flow path with a colloidal solution containing an antithrombotic polymeric compound, and moving the colloid solution between the blood inlet port and the blood outlet port for a time that coats a predetermined amount of antithrombotic polymeric compound on the outer surfaces of the hollow fiber membranes. Other surfaces within the oxygenator contacting the blood flow likewise receive the coating.

In some examples, a membrane module includes a fiber bundle. The fiber bundle includes a tubular first region and a tubular second region positioned around the tubular first region. One of the first or second regions includes hollow fibers oriented along an axis of the fiber bundle. Another of the first or second regions includes hollow fibers that are not colinear in a radial direction from the axis of the fiber bundle. A void fraction of the second region is different from a void fraction of the first region.

In some examples, a membrane module includes a fiber bundle. The fiber bundle includes a tubular first region and a tubular second region positioned around the tubular first region. One of the first or second regions includes hollow fibers oriented along an axis of the fiber bundle. Another of the first or second regions includes hollow fibers that are not colinear in a radial direction from the axis of the fiber bundle. A void fraction of the second region is different from a void fraction of the first region.

The invention relates to a method for producing a device for a mass transfer between two fluids, wherein at least one hollow-fiber mat (9) is wound on an at least partly hollow core assembly (1, 1a, 1b, 2), and the formed coil is inserted into a housing (10). The assembly of the housing (10) and the coil is then sealed (10), in particular potted, with a sealant at the opposing axial ends in the regions between the hollow-fiber ends and the housing. The core assembly (1, 2) is made of at least two axially adjacent core parts (1, 1a, 1b, 2) arranged one behind the other, at least one (1, 1a, 1b) of which has a hollow design, and the core parts (1, 1a, 1b, 2) are kept in specified axial positions relative to each other, in particular at a distance to each other, by means of at least one aid element (7) at least over the period of the sealing process and preferably over the period of the winding process as well. After the sealing process and the removal of the at least one aid element (7), at least the axially end-face core parts (1, 1a, 2) are kept in their relative positions to each other by means of the sealant. The invention also relates to a coil, a core assembly, and a core system.