A membrane filter apparatus for splitting a feed into filtrate and retentate is provided. The apparatus comprises a body chamber, a feed inlet disposed on the body chamber, a retentate outlet located in the body chamber, a feed distribution tube connected to the feed inlet, and a filter assembly having a filter. The feed distribution tube has a length sufficient to cause the feed to enter the body chamber at a feed distance from the filter assembly of no greater than 50% of a total length of the body chamber. The feed flows across the filter in a direction parallel to a surface of the filter assembly. The filtrate passes through the filter assembly and the retentate flows through the body chamber in a direction antiparallel to the feed flow through the feed distribution tube and out through the retentate outlet.

Described herein are fluid treatment devices for use in tangential flow filtration, comprising a housing unit and a composite material, wherein the composite material comprises: a support member comprising a plurality of pores extending through the support member; and a non-self-supporting macroporous cross-linked gel comprising macropores having an average size of 10 nm to 3000 nm, said macroporous gel being located in the pores of the support member. The invention also relates to a method of separating a substance from a fluid, comprising the step of placing the fluid in contact with an inventive device, thereby adsorbing or absorbing the substance to the composite material contained therein.

The present technology provides micro fabricated filtration devices, methods of making such devices, and uses for microfabricated filtration devices. The devices may allow diffusion to occur between two fluids with improved transport resistance characteristics as compared to conventional filtration devices. The devices may include a compound structure that includes a porous membrane overlying a support structure. The support structure may define a cavity and a plurality of recesses formed in a way that can allow modified convective flow of a first fluid to provide improved diffusive transport between the first fluid and a second fluid through the membrane.

Hydrogen generation assemblies and methods of generating hydrogen are disclosed. In some embodiments, the method may include receiving a feed stream in a fuel processing assembly of the hydrogen generation assembly; and generating a product hydrogen stream in the fuel processing assembly from the received feed stream. Generating a product hydrogen stream may, in some embodiments, include generating an output stream in a hydrogen generating region from the received feed stream, and generating the product hydrogen stream in a purification region from the output stream. The method may additionally include receiving the generated product hydrogen stream in a buffer tank of the hydrogen generation assembly; and detecting pressure in the buffer tank via a tank sensor assembly. The method may further include stopping generation of the product hydrogen stream in the fuel processing assembly when the detected pressure in the buffer tank is above a predetermined maximum pressure.

A catheter for intravascular use has a blood inlet and a blood outlet, and includes a membrane arranged in the catheter in such a way that at least one part of the blood flowing into the catheter via the blood inlet during operation comes into contact with the membrane. The membrane allows an exchange of at least one substance between a carrier medium and the blood. The carrier medium is a carrier fluid in which the substance to be exchanged can be dissolved, and the catheter includes a delivery device that is designed to at least partially compensate for a pressure difference between the blood inlet and the blood outlet during operation. A method for removing at least one substance from venous blood for diagnostic purposes uses a device of this type.

A new method is disclosed for extracting plasma from whole blood and metering the amount of plasma to an exact volume for dispensing into a diagnostic test, in a fully automatic and self-contained device. The device can be used in resource limited settings by unskilled users to facilitate sophisticated medical diagnostic testing outside of a hospital clinic or laboratory.

A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.

A membrane structure body having a matrix structure and a biomolecule filter using the same are disclosed. The membrane structure body having a matrix structure, according to one embodiment of the present disclosure, comprises: a filtering part which includes a window region in which a plurality of window cells are formed in a matrix shape and a blocking region in which the window cells are not formed, and which filters biomolecules from a sample moving along the window region; and a support part extending from the filtering part so as to support the filtering part, wherein each of the window cells formed in the window region of the filtering part has have micro-holes allowing the biomolecules having a predetermined size or less to pass therethrough

The invention relates to a gas in/outlet-adapter system for a container/rack assembly for a diagnostic robot comprising: —a receptacle (15) comprising a gas-inlet wherein the receptacle (15) is attached to a container (12), —a nozzle (16) comprising a gas-outlet wherein the nozzle (16) is attached to a rack to supply the container (12) via the receptacle (15) with a gas at a defined pressure level, wherein the receptacle (12) —provides one opening (24) —which provides for a fluidic contact to the interior of the container (12) —and a second opening (25) —which provides for a gas leak-proof connection to the nozzle (16) on the rack when the receptacle (15) is placed over the nozzle (16), and wherein the nozzle (16) —provides one opening (26) —which provides for a fluidic contact to a tubing system of the rack—and a second opening (27) —which provides for a fluidic contact to the nozzle (16) when the receptacle (15) is placed to cover the nozzle (15).

A vacuum manifold for filtration microscopy includes a manifold top having multiple openings, and a capture membrane positioned above and spaced apart from the manifold top, where the capture membrane is configured to deflect into contact with a surface of the manifold top when a negative pressure is applied to the multiple openings. A method for filtration microscopy includes the steps of providing a vacuum manifold including a manifold top having a plurality of openings, and a capture membrane positioned above and spaced apart from the manifold top; applying sample drops to sample spots on the membrane, the sample spots positioned above the plurality of openings; applying a negative pressure to the openings such that the capture membrane contacts a surface of the manifold top; and optically imaging particulates on the capture membrane.