A renal therapy apparatus includes a blood filter, a blood pump, a treatment fluid pump, and a control unit configured to control at least one of the blood pump or the treatment fluid pump during a filter cleaning sequence. The blood filter includes a plurality of hollow fiber membranes. During the filter cleaning sequence, a fluid mixture is formed by mixing air with a blood-compatible and physiologically safe fluid. Also during the filter cleaning sequence, the fluid mixture is transferred across insides and/or outsides of the plurality of hollow fiber membranes at least one time. The use of the fluid mixture enables the filter cleaning sequence to be performed during the blood treatment.

The present invention provides a membrane filtration module comprising a housing in which the filtration membrane is disposed in a fixed positional relationship by a potting or bonding material obtained by the curing of a two component (2K) composition consisting of: a first component (A) comprising at least one compound (a) having at least two acetoacetate functional groups; and, a second component (B) comprising at least one compound (b) having at least one amino group, each said amino group being a primary or secondary amino group.

A method for degassing a cross-flow diafiltration unit, a cross-flow diafiltration method and a cross-flow diafiltration unit. The degassing method includes (i) providing a cross-flow diafiltration unit having a diafiltration channel, a retentate channel and a permeate channel, a first filter material that delimits the diafiltration channel from the retentate channel, and a second filter material that delimits the retentate channel from the permeate channel; and thereafter (ii) feeding a liquid into the retentate channel so that the liquid flows in a flow direction through the retentate channel and penetrates through the first filter material into the diafiltration channel, whereby the retentate channel and the diafiltration channel are filled with and degassed by the liquid

Biocide can be controllably added to a feed stream for a membrane. The membrane can separate the feed stream into a purified permeate stream and a concentrate stream containing contaminants from the feed stream. In some examples, a charge neutral biocide is introduced into the feed stream at a first addition rate. The concentration of the charge neutral biocide in the permeate stream is measured to provide a measured concentration of the charge neutral biocide in the permeate stream. The addition rate of the charge neutral biocide can be adjusted based on the measured concentration of the charge neutral biocide in the permeate stream to introduce charge neutral biocide into the feed stream at a second addition rate different than the first addition rate.

The present invention relates to a melt-joined filter element with improved testability after dry steaming or alternatively after sterilization by irradiation, to a method for producing the filter element according to the invention, and to the use of the filter element for filtering solutions.

Disclosed herein methods for combating biofouling in a liquid, e.g. an aqueous medium by providing a surface coated with at least one laser-induced graphene (LIG) layer in said liquid medium. Particularly disclosed herein method and devices for treating water comprising passing a water stream through a membrane module equipped with at least one spacer coated with at least one layer of LIG, and optionally by applying an electric potential to the at least one LIG layer to achieve a bactericidal effect in the water stream. Specifically, disclosed herein a polymeric mesh suitable for use as a spacer in a membrane module in water treatment application, said mesh being at least partially coated with LIG.

A filter system (100) for biopharmaceutical processes includes: at least one filter unit (10); and at least one distributor plate (200), against which the filter unit rests. A tubeless distributor unit (202) is arranged within the distributor plate and is fluidically connected to the filter unit. The distributor unit guides the fluid to be filtered to the filter unit and/or receives and discharges the filtered fluid from the filter unit. The distributor unit includes at least one active control element (232; 238), with which a fluid flow (14) through the distributor unit) and the filter unit is controlled in an open loop flow or a closed loop flow. The fluid connection between the filter unit and the distributor plate is tubeless. Also provided are a distributor plate (200) for a filter system (100) for biopharmaceutical processes and a method for producing a filter system (100) for biopharmaceutical processes.

The membrane cleaning device uses treated water filtered through an MBR separation membrane as dissolution water, and performs a first process of dissolving ozone gas in the dissolution water under a neutral or alkaline condition, and a second process of dissolving ozone gas in the dissolution water under an acidic condition, to generate ozone water. At this time, whether to shift from the first process to the second process is determined on the basis of the organic substance concentration in the dissolution water, and whether to start feeding the ozone water to the separation membrane is determined on the basis of the dissolved ozone concentration in the dissolution water. Therefore, even when the organic substance concentration in the dissolution water varies depending on the MBR operation conditions, the treatment times in the first process and the second process can be optimized.

A non-oxidizing, buffered disinfectant concentrate is provided to be included in a solution used to disinfect a membrane. The solution applied to the membrane is configured to have a pH that is compatible with the membrane. The disinfectant concentrate includes an aqueous solvent; a hydrotrope; a strong acid surface cleanser; a biocidal active, preferably, at least two biocidal actives; a buffer agent; and, optionally, an anionic surfactant. The biodical active may be selected to function both as a biocide and as a weak acid/buffer combination. A disinfectant solution applied to the membrane includes from about 0.1 wt % to about 3.5 wt % of this disinfectant concentrate.

The disclosure pertains to sanitizing the permeate flow path of a reverse osmosis system. A method of sanitizing a filtration system is disclosed that can include injecting a biocide into a permeate compartment of an operating reverse osmosis system. The method can also include maintaining pressure in a concentrate compartment of the reverse osmosis system simultaneously while injecting the biocide.