Embodiments of the present invention provide for flow control devices on a spiral wound membrane, on a device proximal the inlet edge of a spiral wound membrane, or both. The flow directing devices can alter fluid flow characteristics to discourage fouling of the inlet fluid paths.

Provided is a spiral membrane element that has a restricted outer diameter and is capable of being decreased in operation energy therefor. The element is a spiral membrane element including plural membrane leaves in each of which a permeation-side flow-channel member is interposed between opposed separation membranes; a supply-side flow-channel member interposed between any two of the membrane leaves; a perforated central pipe on which the membrane leaves and the supply-side flow-channel member are wound; and a sealing part that prevents a supply-side flow-channel member from being mixed with a permeation-side flow-channel member. This element has an efficiency index E of 0.005 to 0.10, the index being calculated in accordance with an expression described below, and the thickness of the supply-side flow-channel member is from 10 to 110 mil. Efficiency index: E=0.0024X0.2373+(Y/(D.sup.2L)) wherein X is a thickness [mil] of the supply-side flow-channel member, Y is an effective membrane area [ft.sup.2] of the separation membranes, D is an outer diameter [inch] of the membrane element, and L is a length [inch] of the membrane element.

The present invention provides compact spiral-wound filter elements having cassette-like performance. The invention further provides filtration systems (e.g., TFF systems) and processes (e.g., SPTFF processes) employing compact spiral-wound filter elements having cassette-like performance.

A component for a spiral wound membrane, suitably for water filtration. The component includes an integrally formed non-uniform lattice structure. The lattice structure includes a first and second repeating unit cell, wherein the first and second unit cell are different.

This invention relates to a multi-element membrane separator and separation method based on spiral-wound membrane elements. It includes a membrane housing, spiral-wound membrane elements, and baffles on both sides of the membrane housing, designed to secure the spiral-wound membrane elements. The permeate tubes of the spiral-wound membrane elements are connected to the openings in the perforated plates. Sealing rings are respectively provided at the connections of the permeate tubes and the perforated plate openings. This multi-element membrane separator enables a more compact arrangement of membrane elements, reducing the footprint of the membrane separation device. It also reduces the use of materials such as membrane housing, pipelines, and connecting fittings, thereby lowering equipment costs and the difficulty of membrane device assembly.

Filter elements for perfusion systems and methods are provided. A filter element sheet includes a microporous membrane having a mean pore size of at least about 0.65 ?m and a feed spacer comprising woven fibers and having an open area of at least about 35%. The filter element sheet can be arranged within a filter element, for example, in a spiral-wound format or in a cassette format. A perfusion system includes at least one filter element and a pump configured to control flow of a liquid feed through the at least one filter element.

A spiral membrane element is provided which has a restricted outer diameter but is heightened in effective membrane area, and further which can be decreased in operation energy therefor. The spiral membrane element is an element including plural membrane leaves L in each of which a permeation-side flow-channel member 3 is interposed between opposed separation membranes 1; a supply-side flow-channel member 2 interposed between any two of the membrane leaves L; a perforated central pipe 5 on which the membrane leaves L and the supply-side flow-channel member 2 are wound; and sealing parts that prevent a supply-side flow-channel from being mixed with a permeation-side flow-channel. The sealing parts include both-end sealing parts 11 in which an adhesive is used to seal two-side end parts of each of the membrane leaves L on both sides of the leaf in an axial direction A1 of the leaf. The thickness T1 of the both-end sealing parts 11 is 390 to 540 m.

A spiral wound filtration assembly including: i) a pressure vessel comprising a feed port, concentrate port and permeate port; ii) at least one spiral wound membrane module comprising at least one membrane envelop wound around a permeate tube which forms a permeate pathway to the permeate port; and iii) a bioreactor having a cylindrical outer periphery extending along an axis (Y) from a first end to a second end, an inlet located near the first end, and an outlet located near the second end;
wherein the spiral wound membrane module and bioreactor are serially arranged within the pressure vessel.

A spiral wound membrane module adapted for hyperfiltration and including at least one membrane envelope and feed spacer sheet wound about a central permeate tube to form an inlet and outlet scroll face and an outer periphery, wherein the feed spacer sheet includes: i) a feed entrance section extending along the permeate collection tube from the inlet scroll face toward the outlet scroll face, ii) a feed exit section extending along the outer periphery from the outlet scroll face toward the inlet scroll face, and iii) a central feed section located between the feed entrance section and the feed exit section; and wherein the feed entrance section has a median resistance to flow in a direction parallel to the permeate collection tube that is less than 25% of the median resistance to flow of the central feed section in a direction perpendicular to the permeate collection tube.

To provide a blood treatment filter device capable of efficiently utilizing a blood treatment filter.

A blood treatment filter device 20 has a filter sheet 26 through which a specific component among components forming blood is harder to pass than other components and a spacer sheet 27 through which the specific component is easier to pass than through the filter sheet 26. The filter sheet 26 has filter through-holes 39 disposed at intervals. The filter sheet 26 and the spacer sheet 27 are spirally wound in an overlapped state. The filter device 20 has seals 31 sealing both end portions in the longitudinal direction of a wound body 25 formed by the filter sheet 26 and the spacer sheet 27 which are spirally wound in a fluid-tight manner. The outer peripheral surface of the wound body 25 is formed by the filter sheet 26.