The present invention relates to a separation membrane element including: a separation membrane; and a permeate-side channel material disposed on a permeate side of the separation membrane, wherein the permeate-side channel material is a rugged sheet object having a recess and a protrusion on at least one face thereof, the rugged sheet object is composed of a porous region formed of a through-hole in a thickness direction of the rugged sheet and a non-porous region other than the porous region, and a rate of a number of the through-hole in the recess of the rugged sheet object to a total number of the through-hole present in the rugged sheet object is 80% or more.

A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.

Provided are reverse-osmosis-membrane device capable of treating raw water including a large amount of membrane foulants, such as MBR-treated water, with stability while preventing a reduction in the amount of permeate, and a method for operating the reverse-osmosis-membrane device. The raw water includes a high-molecular organic substance having a molecular weight of 10,000 or more at a concentration of 0.01 ppm or more. The reverse-osmosis-membrane device includes a reverse-osmosis-membrane element including a membrane unit, the membrane unit including a reverse osmosis membrane having a thickness of 0.1 mm or less, a feed spacer disposed on a surface of the reverse osmosis membrane, and a permeate spacer disposed on the other surface of the reverse osmosis membrane. The reverse-osmosis-membrane device is operated at a permeation flux of 0.6 m/d or less.

Spacers for filtration applications are provided. A spacer for a filtration device comprises a substrate comprising a cyclic polyolefin. The substrate comprises a plurality of through-holes for filtering particles having an average particle size of greater than 50 ?m. Filtration assemblies, filtration devices, and related systems and methods are also provided.

Spacers for filtration membranes that are formed from perforated films. The spacer include unperforated regions, which can serve as integrated lamination strips, advantageously omitting the need for separate lamination steps required with woven and nonwoven spacer fabrics while also providing a spacer with a uniform thickness.

The purpose of the present invention is to provide a highly reliable membrane module for removing hazardous components without the risk of a feed-source fluid and a concentrated fluid intermixing inside a hollow tube. The spiral wound separation membrane module is characterized in that: a spiral wound separation membrane element accommodated in a cylindrical container, the spiral wound separation membrane element having a structure in which a laminated body having a separation membrane, a feed-side spacer and a permeation-side spacer is wound around a porous hollow tube in a spiral shape, the feed-side spacer is positioned on a feed side of the separation membrane, the permeation-side spacer is positioned on a permeation side of the separation membrane, and a feed-side flow path and a permeation-side flow path are sealed so as not to communicate directly with each other.

The present invention provides a separation membrane element packed with a rugged sheet object, the separation membrane element being effective in attaining both stabilization of steps for producing the separation membrane element and an increase in fresh-water production rate. The present invention relates to a separation membrane element including: a separation membrane; and a permeate-side channel material disposed on a permeate side of the separation membrane, in which the permeate-side channel material is a porous sheet object having a recess and a protrusion on at least one face thereof, the recess being a coarsely porous region and the protrusion being a densely porous region.

A separation membrane element of the present invention includes: a separation membranes each having a feed-side face and a permeate-side face and forming a separation membrane pair by being arranged so that the permeate-side faces face each other; and a permeate-side channel material provided between the permeate-side faces of the separation membranes, the permeate-side channel material includes a sheet and a plurality of projections formed on the sheet, the sheet is a porous sheet having pores on a surface thereof, and has densely fused parts, coarsely fused parts and non-fused parts on the surface, and the projections contain a resin, and a part of the resin is impregnated into the pores of the sheet.

The present invention relates to a flat-sheet separation membrane element having formed therein a separation membrane pair in which separation membranes are disposed such that permeation-side faces thereof face each other and in which a channel material is provided, wherein the area of a high-elasticity region satisfying a bending modulus of 100-1000 MPa and a maximum bending stress of 1-15 MPa at least in one direction is not less than 10% of the area of a filtration region of the pair of separation membranes.

A panicle separation multi-membrane matrix device and method are provided. The particles isolated may comprise noun-scale particles, such extracellular membrane vesicles, having a size of about 50 to about 150 nm. The vesicles are released by many different cell types, and may be efficiently isolated at high yield and purity according to the present methods from various body fluids (e.g., blood, saliva, breast milk, serum, plasma, ascites fluid, etc.). Such isolated exosome preparations may include biomarkers, such as disease biomarkers (diagnostic markers) for various disease (early stage and late stage cancers, neurological disorders (Parkinson disease, Alzheimer disease), diabetes, pancreatic diseases, renal failure, infectious diseases (HIV, tuberculosis, malaria, hepatitis)). The present methods and devices may be used to detect and monitor animals (human, live-stock, companion animal) for infectious diseases, such as tuberculosis and other diseases. The methods and devices require minimal sample material (10 ?l), are rapid, economical, yield highly enriched small molecule (e.g., exosoines) preparations, and do not require electricity.