A method and system for collecting a double volume of red blood cells using a spinning membrane separator is provided by which a first quantity of whole blood is withdrawn from a donor; a first quantity of whole blood is flowed to the spinning membrane separator; where it is separated into a first quantity of red blood cells and a first quantity of plasma. The first quantity of red blood cells and the first quantity of plasma are then flowed to respective collection containers, and at least a portion of the first quantity of plasma is returned to the donor. A second quantity of whole blood withdrawn from the donor, and then separated into a second quantity of red blood cells and a second quantity of plasma using the spinning membrane separator. The second quantity of red blood cells and the second quantity of plasma are then flowed to the respective collection containers, and at least a portion of the second quantity of plasma is returned to the donor.

A filtration device (1) has a housing (4) and a filter module (2) with hollow fibers (32) surrounded by an outer shell (5). The hollow fiber bundle (6) is sealed to the outer shell (5) at each end by an adhesive (11) transverse to the longitudinal direction (10). Each end of the hollow fibers (32) is unclosed. An unfiltered product chamber (20) is between the outer shell (5) and a wall (19) of the filter housing (4) and a filtered product chamber (13) is inside the filter module (2). The bottom end of the filter module (2) connects with an intermediate section (3) that connects with a receptacle (17) of a bottom portion (15) of the filter housing (4). The intermediate section (3) forms a connection chamber (26) facing the hollow fiber ends (29) and radial feed channels (28) connect the connection chamber (26) with the unfiltered product chamber (20).

Provided is a multi-functional filter including a first filter and a second filter to purify a biological fluid, a housing defining an adsorption section outside of the first filter and the second filter, a flow partitioning connector connecting the first filter and the second filter, and a housing port allowing a fluid to flow through the adsorption section. The housing may comprise a wall, a first cap coupled to the first filter at one end of the wall along a longitudinal direction, and a second cap coupled to the second filter at the other end of the wall along a longitudinal direction. The multi-functional filter according to the present invention in which dialysis, adsorption, and plasma separation or ultrafiltration are integrated to purify blood or dialysate and the internal flow is facilitated may provide a blood purifying apparatus that simplifies the whole apparatus, provides convenience in installation and use, and reduces a treatment cost.

A water purifier, including a housing, a piston cylinder, a base, and a dust cap. The housing includes a water inlet end and a water outlet end, and a composite filter material and an ultrafiltration membrane are disposed in the housing to constitute a filter element. The piston cylinder is sleeved on the housing. The upper end of the piston cylinder is provided with a suction nozzle. The base includes an upper part and a lower part. The upper part includes a lower bayonet and an upper bayonet. The lower part includes a multipurpose interface and a water inlet nozzle. The dust cap is disposed on the upper end and covers the suction nozzle. The central part of the dust cap protrudes downward to form a flexible sealing plug. The water inlet end of the housing is secured to the lower bayonet of the base.

A movable seal for interfacing between a first surface and a second surface includes a floating portion attached to a non-floating portion by a flexible coupling portion, wherein the non-floating portion is coupled to the first surface by nesting in a groove on the first surface, and wherein the non-floating portion forms a seal between the first and second surfaces when the first surface moves relative to the second surface in a first direction, and wherein the non-floating portion does not form a seal between the first and second surfaces when the first surface moves relative to the second surface in a second opposite direction.

A hollow fiber module (1, 1) is made by inserting a bundle of hollow fibers (3) into a housing (2, 2) that has an end closed by a cap (17). A fluid first component (27) that can assume a solid state is introduced into a space adjacent the cap (17) and forms a spacer into which ends of the hollow fibers (6, 7) project. A fluid curable second component (4) is introduced before the first component (27) via a second inflow (28) and is cured to form a sealing layer (9) that embeds the bundle of hollow fibers (3) and seals it with respect to the adjacent housing wall (29, 29). The cap (17) is removed from the module housing (2, 2) along with the first component (27) and ends of the hollow fibers (6) embedded in the first component (27).

Provided is a multi-functional filter including a first filter and a second filter to purify a biological fluid, a housing defining an adsorption section outside of the first filter and the second filter, a flow partitioning connector connecting the first filter and the second filter, and a housing port allowing a fluid to flow through the adsorption section. The housing may comprise a wall, a first cap coupled to the first filter at one end of the wall along a longitudinal direction, and a second cap coupled to the second filter at the other end of the wall along a longitudinal direction. The multi-functional filter according to the present invention in which dialysis, adsorption, and plasma separation or ultrafiltration are integrated to purify blood or dialysate and the internal flow is facilitated may provide a blood purifying apparatus that simplifies the whole apparatus, provides convenience in installation and use, and reduces a treatment cost.

A membrane filter for filtering a liquid to be filtered, having a downwardly open base element through which flow can pass and which has a tubular shell and precisely one membrane carrier arranged therein, wherein the membrane carrier is connected to the shell by way of at least one anchoring point, having hollow fiber-type membranes fastened at the top in the membrane carrier, having a circumferentially closed pipe which, adjoining the top of the shell of the base element, surrounds the hollow fiber-type membranes, having a gas inlet into the base element, having at least one permeate collecting chamber, having at least one permeate outlet, and having at least one downwardly open flow chamber between the shell and the membrane carrier, which flow chamber has an outlet at the top, wherein the at least one flow chamber, in every horizontal section, adjoins both the shell and the membrane carrier.

Provided are a blood purifying filter and a blood purifying apparatus having the same. The blood purifying filter includes a plasma separation filter separating plasma from blood, a hemodialysis filter configured in parallel with the plasma separation filter to remove toxins and waste products from blood, a housing providing installation space for the plasma separation filter and the hemodialysis filter, and plasma inlet and outlet ports provided in the housing. The housing further includes a wall, a lower cap and an upper cap which are coupled to the plasma separation filter and the hemodialysis filter.

In a hollow fiber membrane module including a housing case, potting material loaded into the housing case, a cap attached to each of both ends of the housing case, and an O-ring closely held by the potting material and the cap, a whole area of the O-ring between a first contact point and a second contact point is exposed when the area is viewed from a central axis passing through a center of the ring shape of the O-ring, the first contact point being a point of contact between the O-ring and the cap, which faces inner cavity defined by an end surface of the potting material facing the cap, an inner circumferential surface of the O-ring and an inner circumferential surface of the cap, and the second contact point being a point of contact between the O-ring and the potting material, which faces the inner cavity.