The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.

The invention relates to a method for the processing of protein-containing suspensions or solutions, for example for concentrating or purifying the protein-containing particles or dissolved protein-containing substance contained in the suspensions or solutions, wherein the protein-containing suspensions or solutions are filtered by means of a filter module and the protein-containing particles or dissolved protein-containing substance retained in the filter module are conveyed out of the filter module by means of a backwashing fluid.

Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means for mixing at least two liquids comprising a multiple inlet flow-controller, the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device configured in single-pass mode.

A membrane filter module configured to treat a liquid contained in a tank at an ambient pressure. The module may have a header, with a bundle containing a plurality of substantially vertical hollow fiber membranes, wherein a lower end of each hollow fiber membrane is fixed in the header. The module may also have a gasification device adapted to periodically generate a gaseous bubble and configured to release the gaseous bubble within the bundle. The module may further have an enclosure that substantially surrounds the bundle that extends from a lower region to an upper region of the membrane bundle, wherein the enclosure is configured to retain the liquid introduced into the enclosure such that the liquid surrounds the membrane bundle. The gaseous bubble has a cross-sectional area that corresponds with a cross-sectional area of the enclosure, such that the cross-sectional area of the gaseous bubble occupies substantially the entire cross-sectional area of the enclosure as it flows along the bundle.

Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means (3) for mixing at least two liquids comprising a multiple inlet flow-controller (2), the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device (1) configured in single-pass mode.

A method of filtering a fluid with components includes providing an alternating pressure. The alternating pressure yields an oscillating transmembrane pressure through volume and pressure variations within a filtration chamber while sealing the filtration chamber. A separation surface can be housed in the filtration chamber wherein an influent is introduced. Components can be concentrated on the separation surface, effectively removing some or all of them from the fluid. To flush the filtration chamber and separation surface, a backwash fluid and components can be introduced and removed from the filtration chamber. While both the components are being concentrated and backwashed, the system can maintain the oscillating transmembrane pressure and varying volume and pressure relative to the separation surface.

A method of cleaning a membrane surface immersed in a liquid medium with a fluid flow, including the steps of providing a randomly generated intermittent or pulsed fluid flow along the membrane surface to dislodge fouling materials therefrom. A membrane module is also disclosed comprising a plurality of porous membranes (6) or a set of membrane modules (5) and a device (11) for providing a generally randomly generated, pulsed fluid flow such that, in use, said fluid flow moves past the surfaces of said membranes (6) to dislodge fouling materials therefrom.

The present disclosure relates to hollow fiber tangential flow filters, including hollow fiber tangential flow depth filters, for various applications, including bioprocessing and pharmaceutical applications, systems employing such filters, and methods of filtration using the same.

A renal therapy apparatus includes a blood filter, a blood pump, a treatment fluid pump, and a control unit configured to control at least one of the blood pump or the treatment fluid pump during a filter cleaning sequence. The blood filter includes a plurality of hollow fiber membranes. During the filter cleaning sequence, a fluid mixture is formed by mixing air with a blood-compatible and physiologically safe fluid. Also during the filter cleaning sequence, the fluid mixture is transferred across insides and/or outsides of the plurality of hollow fiber membranes at least one time. The use of the fluid mixture enables the filter cleaning sequence to be performed during the blood treatment.

A method of separating heavy water from normal through application of acoustic pressure shock waves to a fluid including heavy water and normal water and recovering separated normal water.