A vacuum deaerator degasses material to be processed by placing a rotating rotor with a screen in a vacuum vessel, introducing a liquid material to be processed into the rotor from the interior thereof and causing the liquid to pass through the screen to refine the same. The vacuum deaerator is characterized in that: the screen is a cylinder with a circular cross-section and is in the form of a porous plate in which a plurality of through holes are opened in the radial direction of the cylindrical screen; and the screen is provided such that the area of inflow openings is greater than the area of outflow openings, where the inflow openings are openings of a plurality of penetration portions provided on the inner wall face of the screen and the outflow openings are openings of the plurality of penetration portions provided on the outer wall dace of the screen. Thus, the processing capacity of the vacuum deaerator is improved without increasing the size of the device.

A continuous slurry-bed tank reactor, comprising a tank reactor body, an agitator, and tubular separation membranes. A method of using the continuous slurry-bed tank reactor comprising adding a catalyst, feeding reactants, stopping feeding the reactants, starting a heating system, changing directions of the reactants flowing through the tubular separation membranes.

A continuous slurry-bed tank reactor, comprising a tank reactor body, an agitator, and tubular separation membranes. A method of using the continuous slurry-bed tank reactor comprising adding a catalyst, feeding reactants, stopping feeding the reactants, starting a heating system, changing directions of the reactants flowing through the tubular separation membranes.

A bioprocess vessel includes a flexible bag or substantially rigid container that defines an interior volume and having a bottom surface, the bottom surface being open or containing an aperture therein for the passage of fluid. A pump is secured to the bottom surface of the flexible bag or substantially rigid container. In some embodiments is secured directly to the flexible bag or substantially rigid container. In other embodiments, the pump is secured indirectly the flexible bag or substantially rigid container using, for example, a port that extends through the aperture on the bottom surface. The port or flanged surface may also be integrated into the pump, which is secured to the vessel. An optional mixing adaptor may be provided inside the interior volume of the flexible bag or substantially rigid container and at least partially covers the inlet that leads to the pump.

Disclosed is a foldable agitator. The foldable agitator according to one aspect of the present invention comprises: a coupling body; impeller arms rotatably coupled to the coupling body; and a piston, inserted in the coupling body so as to be movable vertically, for rotating the impeller arms in the process of moving to induce same to fold and unfold.

Disclosed is a foldable agitator. The foldable agitator according to one aspect of the present invention comprises: a coupling body; impeller arms rotatably coupled to the coupling body; and a piston, inserted in the coupling body so as to be movable vertically, for rotating the impeller arms in the process of moving to induce same to fold and unfold.

This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals, using Disposable Containers (DCs).

A jet propulsion dry powder dissolution unit that includes a hollow chamber, an upper blending reactor, an impeller, a stator, a stator compartment, a blending reactor nozzle, a submersible actuator, a lower blending reactor, and a solution outlet blending reactor.

A jet propulsion dry powder dissolution unit that includes a hollow chamber, an upper blending reactor, an impeller, a stator, a stator compartment, a blending reactor nozzle, a submersible actuator, a lower blending reactor, and a solution outlet blending reactor.

Methods and apparatuses for producing a substrate are described. A method and apparatus for introducing a component into a fluid supply is also presented. A method can include providing a first fluid supply. The fluid supply can be configured as a foam in some embodiments. The method can also include providing a component feed system and a supply of the component. The method can include introducing the component to a fluid supply in an eductor in some aspects. A resultant slurry including a fluid supply and the component can be transferred through a headbox. The resultant slurry can be dewatered to provide a substrate including the component.