The present disclosure relates to a combination including an outer container for mounting in a container holder of a planetary mixer, the outer container receiving an inner container arrangement allowing to mix ingredients into the inner container arrangement with the planetary mixer to produce in the inner container arrangement a pharmaceutical composition. The outer container may include a body having an outer wall and an inner wall. The inner wall may delimit a central cavity for nestably receiving the inner container arrangement. The outer container may also include a slot on the inner wall. The slot may engage with a protrusion on the inner container arrangement when the inner container arrangement is received in the central cavity to inhibit rotational motion of the inner container arrangement within the outer container, induced as a result of combined rotation and revolution imparted to the outer container by the planetary mixer.

An anti-segregation mixer for a bed of material, the anti-segregation mixer comprising: an elongate and substantially cylindrical shell having an inner surface; and a plurality of independent lifting means provided within the shell, wherein the plurality of lifting means each comprise a vane with a leading end and a trailing end, and are arranged with respect to the cylindrical shell such that the vane is spaced apart from the inner surface and the entire lifting means may pass through the bed of material.

A mixing drum includes a body defining a head aperture and a discharge aperture opposite the head aperture, a head coupled to the body and extending across the head aperture, a bearing member coupled to the body and defining a bearing surface surrounding the body, and a mixing element positioned within the volume and coupled to the body. The head and the body define a volume configured to contain a fluid mixture. The mixing element is configured to drive the fluid mixture toward the head when the drum is rotated in a first direction. The mixing element is configured to drive the fluid mixture towards the discharge aperture when the mixing drum is rotated in a second direction opposite the first direction. The head is made from a first material, and the body is made from a second material having a lesser density than the first material.

The present disclosure relates to a system and process for manufacturing patient personalized pharmaceutical compositions using superimposed revolution and rotation movements for dispersing, milling, melting, and/or de-aerating, where these superimposed revolution and rotation movements can be carried out in a single device in a pharmacy setting.

The present disclosure relates to a system and process for manufacturing patient personalized pharmaceutical compositions using superimposed revolution and rotation movements for dispersing, milling, melting, and/or de-aerating, where these superimposed revolution and rotation movements can be carried out in a single device in a pharmacy setting.

A tumbler crystallizer for crystallizing pelleted, tacky, polymeric materials includes a housing for rotatably supporting a removable paneled drum on rollers. The removable panels may be made of a transparent, heat-insulating material. The drum receives a flow of hot pellets through an inlet chute, and a tumbling action of the drum and internal agitators keeps the pellets in motion relative to each other to prevent agglomeration until they reach a desired level of crystallinity and are no longer tacky. Baffle plates are provided at intervals along the length of the drum to slow the flow of pellets therethrough to increase residence time. Damper plates are provided near the exit end of the drum to aid in building a bed of pellets within the drum, and also to control residence time of the pellets within the drum.

The present invention provides a method and kit which can be used to prevent or reduce contaminants in a clean production environment. The method involves providing a processing apparatus having a chamber, and providing a liner within the chamber, wherein a negative pressure is applied to the interior of the chamber to retain the liner against the interior wall of the chamber.

A device for mixing and dispensing a flowable material or mixture of materials, the device comprising a cup having a bottom with a protrusion having an opening; a plunger having a dispensing port and air vent holes; a plug; a nozzle; and, a lid. The plug can be associated with and plug the cup protrusion opening when the cup is being filled or mixed, or the plug can be associated with the plunger port to seal off the air vent holes when material is dispensed from the device. Also disclosed is a method of mixing and dispensing a flowable material.

A dispensing container and adapter system for use with a planetary mixer is disclosed. The dispensing container has a longitudinal axis and a transverse axis. The dispensing container may include a nozzle and a removable cap to cover the nozzle. The removable cap may have a first width dimension measured along the transverse axis. The dispensing container may include a body having a second width dimension measured along the transverse axis. An adapter may receive the dispensing container. The adapter may include a cavity to receive the removable cap. The cavity may have a cavity width that exceeds the first width dimension. The adapter may also include a recess for receiving a portion of the dispensing container. The recess may extend from the cavity. At least a portion of the recess may have a width dimension smaller than both the first width dimension and the second width dimension.

A dispensing container and adapter system for use with a planetary mixer is disclosed. The dispensing container has a longitudinal axis and a transverse axis. The dispensing container may include a nozzle and a removable cap to cover the nozzle. The removable cap may have a first width dimension measured along the transverse axis. The dispensing container may include a body having a second width dimension measured along the transverse axis. An adapter may receive the dispensing container. The adapter may include a cavity to receive the removable cap. The cavity may have a cavity width that exceeds the first width dimension. The adapter may also include a recess for receiving a portion of the dispensing container. The recess may extend from the cavity. At least a portion of the recess may have a width dimension smaller than both the first width dimension and the second width dimension.