The present invention generally relates to the production of fluidic droplets. Certain aspects of the invention are generally directed to systems and methods for creating droplets by flowing a fluid from a first channel to a second channel through a plurality of side channels. The fluid exiting the side channels into the second channel may form a plurality of droplets, and in some embodiments, at very high droplet production rates. In addition, in some aspects, double or higher-order multiple emulsions may also be formed. In some embodiments, this may be achieved by forming multiple emulsions through a direct, synchronized production method and/or through the formation of a single emulsion that is collected and re-injected into a second microfluidic device to form double emulsions.

A fluid mixer includes a flow splitter and a mixing chamber. The flow splitter includes an inlet for receiving a flow of fluid and is configured to split the flow of fluid into first and second fluid streams. The second fluid stream has a higher density than the first fluid stream. The mixing chamber includes a first inlet, a second inlet and a mixing well. The second inlet is positioned below the first inlet. The second inlet of the mixing chamber is configured to receive the first fluid stream and the first inlet of the mixing chamber is configured to receive the second fluid stream to promote mixing of the first and second streams in the mixing well.

During the use of a liquid mixing apparatus, a liquid container can be installed onto an adapter. The liquid container drives a lifting assembly to allow a piercing assembly to pierce through the adapter. Once a fluid flows into a flowing passage portion via a fluid inlet, a portion of the fluid is pressurized via a branch passage portion with easy control and further flows into the liquid container to mix with a fragrance material inside the liquid container. The mixed fragrant liquid then flows out of a fluid outlet from the piercing assembly via the return passage portion and the flowing passage portion. With the pressurization design of the branch passage portion, the apparatus allows the increase of dimension to increase the flow rate while maintaining the pressurized liquid, which is convenient to use and facilitated for the control of the mixture amount with greater variation range.

During the use of a liquid mixing apparatus, a liquid container can be installed onto an adapter. The liquid container drives a lifting assembly to allow a piercing assembly to pierce through the adapter. Once a fluid flows into a flowing passage portion via a fluid inlet, a portion of the fluid is pressurized via a branch passage portion with easy control and further flows into the liquid container to mix with a fragrance material inside the liquid container. The mixed fragrant liquid then flows out of a fluid outlet from the piercing assembly via the return passage portion and the flowing passage portion. With the pressurization design of the branch passage portion, the apparatus allows the increase of dimension to increase the flow rate while maintaining the pressurized liquid, which is convenient to use and facilitated for the control of the mixture amount with greater variation range.

Some embodiments relate to a device for performing continuous emulsion of two immiscible fluids. The device includes: a first microsystem including at least two micro-channels for intake of each fluid, of different respective cross sections S1 and S2, which are offset and face each other along a central intake axis A; at least two micro-channels for output of the emulsion from the device once the emulsion is formed; and an area where the intake and output micro-channels intersect, the area being capable of generating an interface between the fluids and forming a pre-emulsion flowing in the output micro-channels until the emulsion is complete. The device also includes at least one singularity capable of destabilizing the interfaces between the fluids in the pre-emulsion.

The present invention generally relates to the production of fluidic droplets. Certain aspects of the invention are generally directed to systems and methods for creating droplets by flowing a fluid from a first channel to a second channel through a plurality of side channels. The fluid exiting the side channels into the second channel may form a plurality of droplets, and in some embodiments, at very high droplet production rates. In addition, in some aspects, double or higher-order multiple emulsions may also be formed. In some embodiments, this may be achieved by forming multiple emulsions through a direct, synchronized production method and/or through the formation of a single emulsion that is collected and re-injected into a second microfluidic device to form double emulsions.

An exemplary compounding system and method can include two pump heads for simultaneously drawing two different fluids from at least two separate input containers such that the at least two different fluids are mixed and distributed to an output container. The system can include a manifold that maintains separation of certain of the different fluids until after passing by a first pump and a second pump and/or additional pumps. A junction can be placed in the fluid line downstream of the first and second pumps and/or additional pumps such that all or some of the fluids are mixed prior to output to the output container. The method of using the system can include incorporating software that selects various fluids at certain times and sequences to ensure optimum efficiency and safety for the system, and can continue compounding actions even when an input supply container runs out or otherwise fails to supply a particular fluid/material. The method of use also includes connection of a transfer set to a housing in a manner that further ensures optimum efficiency and safety.

The application relates to microfluidic apparatus and methods of use thereof. Provided in one example is a microfluidic device comprising: a first fluidic input and a second fluidic input; and a fluidic intersection channel to receive fluid from the first fluidic input and the second fluidic input, wherein the fluidic intersection channel opens into a first mixing chamber on an upper region of a first side of the first mixing chamber, wherein the first mixing chamber has a length, a width, and a depth, wherein the depth is greater than about 1.5 times a depth of the fluidic intersection channel; an outlet channel on an upper region of a second side of the first mixing chamber, wherein the outlet channel has a depth that is less than the depth of the first mixing chamber, and wherein an opening of the outlet channel is offset along a width of the second side of the first mixing chamber relative to the fluidic intersection.

The present invention relates to compositions and methods for manufacturing an adjuvant comprising a saponin using a microfluidic device and to aspects thereof.

A microchannel device includes: an upstream channel portion configured to allow an upstream liquid plug and a gas to flow therethrough; a downstream channel portion configured to allow a downstream liquid plug and a gas to flow therethrough; a liquid holding portion provided between a downstream end portion of the upstream channel portion and an upstream end portion of the downstream channel portion, the liquid holding portion being configured to hold a main liquid plug therein; and a gas bypass channel portion provided so as to bypass the liquid holding portion from the downstream end portion of the upstream channel portion to the upstream end portion of the downstream channel portion, the gas bypass channel portion being configured to allow the gas to flow therethrough in a state in which the liquid holding portion holds the main liquid plug.