A processing receptacle for a biopharmaceutical product includes a pocket configured to accommodate the biopharmaceutical product that can assume a flat-folded state, an expanded state, or any intermediate state in between, a processing element having an active inner portion, a rigid protective chamber to protect the processing element, and at least one opening for introducing the product into the receptacle and/or for draining the contents from the receptacle. A portion of the protective chamber is rigidly attached to a portion of the pocket and movement of the pocket up or down brings about movement of the protective chamber; the processing element and the protective chamber are arranged to be independent from one another relative to their movements. The protective chamber has a variable height that automatically adapts to accommodate the flat-folded, expanded, or intermediate state of the pocket, and in each state of the pocket, the processing element is offset from the side walls and the upper end portion of the pocket, while being adjacent to the lower end portion. A device having such a processing receptacle and a method for processing a biopharmaceutical product utilizing such a device are also presented.

A mounting assembly is provided, including: a drive coupler shaped to engage a coupling member on a shaft positionable within a container defining an aperture to allow passage of the shaft; and a funnel positioned within the aperture to receive the drive coupler and guide the drive coupler to the coupling member. The assembly provides ergonomic advantages as the user is not required to lift the drive to reach the aperture.

A vessel configured to contain a liquid is provided. The vessel includes a collapsible bad, a reusable support structure, a sensor, and a controller. The collapsible bag is operative to contain the liquid. The reusable support structure is operative to support the collapsible bag. The sensor is operative to measure a parameter within the collapsible bag. The controller is in electronic communication with the sensor and operative to introduce an antifoaming agent into the collapsible bag based at least in part on a signal received from the sensor.

A bioreactor configured to contain a volume of liquid is provided. The bioreactor includes a collapsible bag able to contain the volume of liquid, a first sparger connected to the collapsible bag, and a second sparger connected to the collapsible bag.

A bioreactor configured to contain a volume of liquid is provided. The bioreactor includes a collapsible bag able to contain the volume of liquid, a first sparger connected to the collapsible bag, and a second sparger connected to the collapsible bag.

A feed-mixing wagon includes a container for receiving feed. The container includes a bottom, and a peripheral wall which is closed off at a bottom end by the bottom. A mixing element is provided for mixing the feed to be accommodated in the container. The peripheral wall is provided with a wall covering which extends at least along a bottom, ring-shaped part of the inner surface of the peripheral wall. The wall covering includes a plurality of wall plate parts with upwardly extending side edges. Two adjoining side edges of at least two respective adjoining wall plate parts are clamped to the inner surface of the peripheral wall by clamping strips which overlap these adjoining side edges and which are attached to the peripheral wall of the container by means of detachable fasteners.

A cylindrical or annular polymeric bioreactor is disclosed which provides enhanced mixing and aeration of the growth medium while simultaneously offering reduced mechanical shear force.

A valve for injecting a fluid into a bowl has a vent with an inlet and a flexible diaphragm for covering the discharge opening of the vent. The diaphragm is connected to a vessel body of a bowl, and the vent is connected to a stand of a bowl. The diaphragm has a closing area for closing the discharge opening and a connecting area for connecting the diaphragm with the vessel body spaced to the vent. At least one window is provided between the closing area and the connecting area.

Systems for containing and manipulating fluids including systems and methods involving supported collapsible bags that may be used as reactors for performing chemical, biochemical and/or biological reactions contained therein are provided. Generally, a series of improvements and features for fluid containment systems such as gas delivery configurations, foam control systems and bag molding methods and articles for supported collapsible bag vessels and bioreactors are provided. For instance, in one aspect, fluids contained in a vessel can be sparged, e.g., such that a fluid is directed into a container of the vessel, and in some cases, the sparging can be controlled by rapidly activating or altering the degree of sparging as needed. Multiple spargers may be used in some cases. In another aspect, the vessel includes a seamless collapsible bag. In some cases, the collapsible bag may be injected, blown, or spin cast molded. In yet another aspect, the vessel includes a device which can reduce the foam produced or contained within the vessel. Sensors and/or controllers may optionally be used to monitor and/or control foaming.

The invention is a package (1) for stereolithography comprising a container (2) filled with stereolithography resin (3), provided with an access opening (4), and a mixer element (5) arranged in a removable manner in the container (2) and provided with at least one magnet (6).