This disclosure relates to equipment utilized to manufacture chemical agents, particularly biopharmaceuticals. In some embodiments, reactor systems comprising a mobile carriage assembly; a disposable reaction container removably attached to the carriage assembly; and, a carriage holder into which the mobile carriage assembly may be removably inserted are provided.

In one example, a liquid container includes an expandable and collapsible bag having a first interior chamber and a second interior chamber separated by a barrier; a passage through the barrier for liquid to pass between the chambers; a first opening between the first chamber and an exterior of the bag; and a second opening between the second chamber and the exterior of the bag.

A mixing apparatus for mixing or stirring substances includes a mixing tank for receiving the substances, a rotor arranged in the mixing tank with which a vane for mixing or stirring the substances can be driven to rotate about an axial direction, and a stator arranged outside the mixing tank and with which the rotor can be driven contactlessly magnetically to rotate about the axial direction in the operating state and is supported magnetically with respect to the stator. A bar extends in the axial direction and is rotationally fixed to the rotor, and a limiting element fixed with respect to the mixing tank cooperates with the bar, with the limiting element being configured such that the bar rotates with respect to the limiting element and with a tilt of the rotor being limited by a physical contact between the bar and the limiting element.

A mixing system includes a container having an encircling sidewall bounding a chamber and extending between an upper end and an opposing lower end; a support plate disposed within the chamber and secured to the encircling sidewall; an inner wall secured to the support plate and projecting within the chamber toward the upper end, an open space being formed between the inner wall and the encircling sidewall; and a first aperture extending through the encircling sidewall so as to communicate with the open space. A mixing assembly is positioned within the container and is supported on the support plate, the mixing assembly including a pliable enclosure and a mixing device.

A mixing system includes a housing having a motor mount rotatably coupled thereto, the motor mount having a passage extending therethrough. A drive shaft is removably positioned within the passage of the motor mount. A cap includes a main body removably coupled to the motor mount and an actuator coupled to the main body so as to be pivotable between a first position and a second position with respect to the main body. The actuator producing a camming action when the actuator is pivoted such that when the actuator is in the first position, the actuator pushes the drive shaft against the motor mount so that the main body is locked to the motor mount and so that rotation of the motor mount causes rotation of the drive shaft and when the actuator is in the second position, the actuator is disengaged from the drive shaft and the cap is removable from the motor mount.

Methods and systems for chromatography are disclosed that employ a flexible container configured to fit within a support structure and adapted to receive a filtration or absorptive medium. The flexible container can include at least one inlet, at least one outlet, and a separation barrier peripherally sealed within the container to separate the container into a resin containing portion and a drainage portion. The barrier can be configured to exclude the resin material from the drainage portion while allowing fluids to pass therethrough. The disposable chromatography system can further include one or more agitators disposed within the flexible container and adjustably configured to be raised or lowered in the flexible container. When the agitator is in the raised position, the resin packing material can operate in a settled, packed-bed configuration. Alternatively, the agitator in the lowered position permits the chromatography resin packing material to operate in a mixed, slurry configuration.

A mixing assembly includes a bag of appropriate size, configuration, shape and material and a closable spout that may have extensions of various lengths, shapes and configurations to provide enhanced mixing of a component contained in the bag upon the addition of a second component. Once the closure of the spout is removed, the second component, typically a liquid such as water, milk, juice, chemical, oil substrate, or the like, can be added to the container for mixing. After the closure is refitted, the two components are mixed then consumed or dispensed, either by removing the closure or from a separate spout or nozzle fitted to the closure.

A coating apparatus with a coating chamber configured for receiving a particulate, a horizontally-oriented rotor having a plurality of paddles mounted thereon, the rotor and the paddles defining a liquid injection path fluidly connected to a liquid injection system, the liquid injection system arranged to supply a liquid under conditions suitable to continuously coat the particulate in a manner that substantially reduces formation of caked solid-liquid mixture on inner walls of the coating chamber.

Disclosed is a mixing chamber apparatus suitable for high-volume sampling (HVS) application. The mixing chamber apparatus includes, among other elements, inlet and outlet manifolds, a mixing chamber, and a tubing manifold for the introduction of clean, turbulent air into the mixing chamber. The inlet manifold defines a plurality of vapor ports that can be in fluid communication with one or more vapor sources to be sampled and mixed within the mixing chamber. Also described herein is a baffled mixing system that can be used alone or in combination with the disclosed mixing chamber apparatus.

A disposable container, such as a deformable bag, for a fluid, having one or more inlets and one or more outlets and an impeller assembly within the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The region within the container that can contain liquid is funnel shaped, which allows very low fluid level mixing, dispensing while mixing, and a reduction or elimination of vortex formation.