Methods and systems of admixing hydrocarbon liquids from a plurality of tanks into a single pipeline thereof. The system may include two or more tanks positioned at a tank farm each containing a hydrocarbon liquid therein. The system may include two or more first main pipes, each connected to one of the tanks. The system may include two or more main valves, each connected to one of the first main pipes. The system may include two or more second main pipes each connected to a corresponding main valve. The system may include two or more mixing jumpers, each connected to a corresponding first main pipe, each mixing jumper to, when a corresponding main valve is closed, control hydrocarbon liquid. The system may include a mixing pipe, connected to the second main pipes and the mixing jumpers, configured to transport hydrocarbon liquid from one or more of the tanks.

Methods and systems of operating a pump at an efficiency point during an in-line blending operation. In an embodiment, such a method may include transporting a fluid from a tank to a pump through a first pipe. The method may include discharging, via the pump, the fluid at a specified flow rate through a second pipe. The method may include measuring a flow rate of the first portion of the fluid flowing from the main control valve through the mixing pipe. The method may include measuring a flow rate of the second portion of the fluid flowing through the spillback loop. The method may include determining a current pump efficiency point and operating the pump within a range of percentages of the best efficiency point.

Examples include microfluidic devices. Example microfluidic devices include a first microfluidic channel, a second microfluidic channel, and a third microfluidic channel fluidly coupled to the first microfluidic channel and the second microfluidic channel via a fluid junction. A fluid actuator is disposed in the third microfluidic channel to actuate to thereby pump a first fluid and a second fluid into the third microfluidic channel.

Systems including specific arrangements of pumps, valves, and conduits, such as for mixing precursors to lipid nanoparticles to form the lipid nanoparticles, are provided. Methods of using such systems to manufacture the lipid nanoparticles are also provided.

Systems and apparatuses for preparing a medical fluid are disclosed. In an example embodiment, a system is configured to initially control a dosing of a first concentrate, while not feeding a second concentrate, under feedback control via a concentration sensor to a first pump to feed the first concentrate. When a concentration has reached a preselected concentration level, a value for a feeding parameter for the first pump to feed the first concentrate is determined. Additionally, the system is configured to control the dosing of both the first and the second concentrates by switching the feedback control via the concentration sensor, from control of the first pump to control of a second pump to feed the second concentrate. During this time, the system controls the first pump to feed the first concentrate based on the determined value of the feeding parameter.

A medicine compounding system has a plurality of containers for containing medical compounds to be used to make up a medicine. A dosing chamber is connected to each of the plurality of containers and a drawing mechanism is used to draw compounds from the plurality of containers to the dosing chamber. A controller receives a script via a communications module which includes details of a patient and a medicine to be dispensed. The controller determines from the script which medical compounds and what quantities of each compound are to be used to form the medicine. The controller controls the drawing mechanism to draw the determined quantity of the medical compound from the container holding the compound into the dosing chamber, and once all of the required medical compounds have been drawn into the chamber to form the medicine, to eject the medicine formed in the dosing chamber via an outlet.

A medicine compounding system has a plurality of containers for containing medical compounds to be used to make up a medicine. A dosing chamber is connected to each of the plurality of containers and a drawing mechanism is used to draw compounds from the plurality of containers to the dosing chamber. A controller receives a script via a communications module which includes details of a patient and a medicine to be dispensed. The controller determines from the script which medical compounds and what quantities of each compound are to be used to form the medicine. The controller controls the drawing mechanism to draw the determined quantity of the medical compound from the container holding the compound into the dosing chamber, and once all of the required medical compounds have been drawn into the chamber to form the medicine, to eject the medicine formed in the dosing chamber via an outlet.

A system for mixing a batch of medicament has a pump actuator, control valve actuators, a source of concentrate, and a purified water source, all connected by a fluid circuit. A controller controls various control valves to open fluid channels from the source of concentrate and from the purified water source to connect a junction of the fluid circuit to the concentrate container and the purified water source. The controller also controls the pump actuator and a water pump to flow water and concentrate through the junction into a mixing container, such that the mixture of the concentrate and the water requires additional dilution to form a ready-to-use medicament. The controller samples the mixture and calculate an additional quantity of water to add based on the sampling.

Provided is a generating method for generating an ultra-fine bubble-containing liquid in which multiple types of UFB s of different gas components are mixed at a desired concentration ratio, and a manufacturing apparatus for a liquid containing ultra-fine bubbles. Multiple types of UFB-containing liquids are generated for each gas contained by the UFBs, and the UFB-containing liquids are mixed with each other based on a mix proportion of a desired UFB concentration.

Embodiments include systems and methods of in-line mixing of hydrocarbon liquids from a plurality of tanks into a single pipeline. According to an embodiment, a method of admixing hydrocarbon liquids from a plurality of tanks into a single pipeline to provide in-line mixing thereof includes determining a ratio of a second fluid flow to a first fluid flow based on signals received from a tank flow meter in fluid communication with the second fluid flow and a booster flow meter in fluid communication with a blended fluid flow. The blended fluid flow includes a blended flow of the first fluid flow and the second fluid flow. The method further includes comparing the determined ratio to a pre-selected set point ratio thereby to determine a modified flow of the second fluid flow to drive the ratio toward the pre-selected set point ratio. The method further includes controlling a variable speed drive connected to a pump thereby to control the second fluid flow through the pump based on the determined modified flow, the pump being in fluid communication with the second fluid flow.