The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.

A manually actuated chromatography device comprising a chamber for receiving a liquid sample, a pump with a metering valve, and a chromatography element, wherein the pump moves a predetermined volume of liquid from the sample chamber to the chromatography element.

Provided is a guard column including a filling part having a length of 2.0 cm to 3.5 cm formed of a filler, in which the filler is made of porous silica gel having a hydrophilized surface and an average particle size of 1.5 μm to 2.5 μm, and a pressure difference when an aqueous solution is fed at a linear flow rate of 2.1 cm/min is 4.0 MPa or more.

The present invention relates to an amphiphilic block copolymer composition which provides enhanced stability to a micelle formed by an amphiphilic block copolymer in an aqueous phase.

Solid phase extraction (SPE) sorbents and liquid chromatography (LC) stationary phases are provided, as well as methods of fabricating the same. The SPE sorbents and LC stationary phases can use microcrystalline cellulose particles as the substrate and sol-gel sorbent coating technology as the polymer/sorbent immobilization technology. The SPE sorbents and LC stationary phases are stable in a pH range of 1-13 and at a temperature of up to 350 ° C.

Solid phase extraction (SPE) sorbents and liquid chromatography (LC) stationary phases are provided, as well as methods of fabricating the same. The SPE sorbents and LC stationary phases can use microcrystalline cellulose particles as the substrate and sol-gel sorbent coating technology as the polymer/sorbent immobilization technology. The SPE sorbents and LC stationary phases are stable in a pH range of 1-13 and at a temperature of up to 350 ° C.

Provided is a packing material for liquid chromatography, including a gel obtained by polymerizing monomers including 40% by mass or more of a crosslinkable monomer having a (meth)acryloyloxy group.

Provided is a packing material for liquid chromatography, including a gel obtained by polymerizing monomers including 40% by mass or more of a crosslinkable monomer having a (meth)acryloyloxy group.

A separation medium for removing small molecules from biomacromolecule in aqueous mixtures comprises gel filtration chromatography beads having a nominal protein fractional range of about 1000 Da to about 5000 Da and having an internal adsorbent matrix derived from a hydrophobicized scaffold. The gel filtration chromatography beads remove small molecules that are less than 1500 Da and have log Pow values greater than about −0.5 from biomacromolecules in aqueous mixtures. Devices containing the separation medium are also provided.

A separation medium for removing small molecules from biomacromolecule in aqueous mixtures comprises gel filtration chromatography beads having a nominal protein fractional range of about 1000 Da to about 5000 Da and having an internal adsorbent matrix derived from a hydrophobicized scaffold. The gel filtration chromatography beads remove small molecules that are less than 1500 Da and have log Pow values greater than about −0.5 from biomacromolecules in aqueous mixtures. Devices containing the separation medium are also provided.