A sorbent cartridge device and a dialysis system comprising a dialysate generation machine dialysate generation machine, a pump adapted to move fluid through the dialysate generation machine, and a sorbent cartridge are described. The sorbent cartridge device fluidically connected to the dialysate generation machine. The sorbent cartridge device includes a housing defining a housing interior, a fluid coupling attached to the housing and configured to fluidically connect at least one fluid line to the housing interior, a baffle attached to a bottom of the housing interior and fluidically connected to the housing interior, the baffle configured to direct fluid flow entering the baffle radially and circumferentially, and a fluid accumulation module attached at the top of the housing and fluidically connected to the housing interior, the fluid accumulation module configured to direct fluid flow entering the fluid accumulation module from a bottom surface of the fluid accumulation module towards a center port of the module.

A sorbent cartridge device and a dialysis system comprising a dialysate generation machine dialysate generation machine, a pump adapted to move fluid through the dialysate generation machine, and a sorbent cartridge are described. The sorbent cartridge device fluidically connected to the dialysate generation machine. The sorbent cartridge device includes a housing defining a housing interior, a fluid coupling attached to the housing and configured to fluidically connect at least one fluid line to the housing interior, a baffle attached to a bottom of the housing interior and fluidically connected to the housing interior, the baffle configured to direct fluid flow entering the baffle radially and circumferentially, and a fluid accumulation module attached at the top of the housing and fluidically connected to the housing interior, the fluid accumulation module configured to direct fluid flow entering the fluid accumulation module from a bottom surface of the fluid accumulation module towards a center port of the module.

A method for producing a protein adsorbent comprising a substrate and a molecular chain fixed on the surface of the substrate is disclosed. The method comprises, in this order: a dry-heat treatment step of heating a pretreatment adsorbent comprising the substrate and the molecular chain fixed on the surface of the substrate, in which the molecular chain contains a weak electrolytic ion-exchange group; and a wet-heat treatment step of heating the pretreatment adsorbent in a moistened state with a liquid or steam to obtain the protein adsorbent.

A method for producing a protein adsorbent comprising a substrate and a molecular chain fixed on the surface of the substrate is disclosed. The method comprises, in this order: a dry-heat treatment step of heating a pretreatment adsorbent comprising the substrate and the molecular chain fixed on the surface of the substrate, in which the molecular chain contains a weak electrolytic ion-exchange group; and a wet-heat treatment step of heating the pretreatment adsorbent in a moistened state with a liquid or steam to obtain the protein adsorbent.