An object of the present invention is to provide an analysis apparatus in which local analysis of a substrate with ICP-MS is automated. The present invention relates to an automatic analysis apparatus for a local region of a substrate, including: a nozzle for local analysis having: analysis-liquid supply means that ejects analysis liquid onto a substrate; analysis-liquid discharge means that takes the analysis liquid including an object to be analyzed from the substrate into the nozzle to feed the analysis liquid to a nebulizer; and exhaust means including an exhaust channel in the nozzle; automatic liquid-feed means that automatically feeds the collected analysis liquid to ICP-MS; flow adjustment means that adjusts the flow of the analysis liquid; and automatic control means that simultaneously performs local analysis and analysis of the object to be analyzed with the ICP-MS to perform automatic analysis to a plurality of adjacent predetermined regions, successively.

DIGITAL TITRATOR, for application in chemical instrumental analysis, comprising a transparent vertical tube (burette) (1), which contains the titrant, monitored by a contact image sensor (CIS) (2), parallel to the tube. A titrant reservoir (3) communicates with said burette, with solution transfer by means of a pump (4). The release of said solution is made by a valve (5) to the reaction flask (6), where a sensor (7) collects and transmits information about the progress of monitored reaction to a computer (8). Analytical data is stored, processed and displayed to the user on a screen, and/or printed. A flexible tube communicates the upper ends of tube and reservoir and transfers saturated internal atmosphere conversely, according as pressure change, caused by meniscus movement, without gas exchange with atmosphere, preventing evaporation of solvent and consequent changes in titrant concentration. For the same purpose, the inlet air from atmosphere to the reservoir goes by a saturation bottle (9) containing pure solvent. A PCI (10) controls operations, assisted by a computer, and an agitator (11) homogenizes reaction flask's content.

A metering head for receiving and metering at least one medium, the metering head including: one or multiple media access points; at least two dispensing terminals each having at least one media outlet; and fluid lines, which connect the one or multiple media access points to the at least one media outlet of the at least two dispensing terminals. In at least one of the fluid lines, an actively controllable element for manipulating and/or detecting the medium in the fluid lines is inserted. A fluidic system, including: a metering head of this type; a microfluidic cartridge; and at least one connecting element for fluidically connecting the metering head to the microfluidic cartridge. The dispensing terminal is designed to indirectly or directly receive the connecting element. The microfluidic cartridge includes: at least one inlet opening for connecting to the at least one connecting element; and a channel structure fluidically connected to the inlet opening.

A mechanism is provided for sensing molecules. A twin-nanopore probe includes a first channel and a second channel. A first pressure-controlled reservoir is connected to the first channel to generate a positive pressure. A second pressure-controlled reservoir is connected to the second channel to generate a negative pressure. A container includes ionic solvent with molecules, and a tip of the twin-nanopore probe is submerged in the container of the ionic fluid with the molecules. The first channel, the second channel, the first pressure-controlled reservoir, and the second pressure-controlled reservoir are filled with the ionic fluid. The first pressure-controlled reservoir drives the ionic fluid out of the first channel and the second pressure-controlled reservoir draws in the ionic fluid with the molecules and solvent through the second channel. A flow of ionic current in the twin-nanopore probe is measured to differentiate the molecules that flow through the second channel.

Disclosed is a reagent dispenser apparatus. The reagent dispenser apparatus has a reagent container having a dispense port operable to open and close to dispense reagent. Dispense port may include a valve operable to dispense reagent from a bottom of the reagent container. Reagent dispensing apparatus, immunoassay apparatus and methods of operating the reagent dispenser apparatus are provided, as are other aspects.

The present invention provides a biological sample holder and handler system for cell-based liquid biopsies. The system is useful for performing diagnostic assays, based on a simple blood sample. For example, the system is useful for delivering precision cancer diagnoses that improve patient outcomes by optimizing treatment options, monitoring therapy efficacy, characterizing metastasis and assessing treatment toxicity

There is provided a method and materials pertaining to assays, for example immunoassays, for biomarkers in body fluids e.g. blood. Diagnostic or screening methods for infections, and methods of differentiating between infectious and non-infectious conditions in mammals, particularly equines, for monitoring response to anti-infective/antibiotic therapy are provided. A test fluid collection system adapted to permit dilution and analysis of the collected test fluid and an assay and device for monitoring exertional rhabdomyolysis in equines is also provided.

An article of laboratory glassware for directing the flow of chemical materials is described. The article includes a glass manifold having a plurality of input ports and at least one output port, and a plurality of stopcocks. Each stopcock has an inlet port and an outlet port connected by a passageway through the plug. Each of the stopcock output ports is connected to one of the manifold input ports, and each stopcock input port is connected with one end of a hollow glass tube, and the other end of the hollow glass tube is connected to a ground glass joint. The output ports of the manifold are terminated to a ground glass joint. Each plug is rotationally coupled to a planetary gear arrangement operated by a stepper or electrical motor, and rotational position can be sensed by a sensor. The rotation of each rotating plug is controlled by a computer.

An article of laboratory glassware for directing the flow of chemical materials is described. The article includes a manifold having a plurality of input ports and at least one output port, and a plurality of stopcocks. Each stopcock has an inlet port and an outlet port connected by a passageway through the plug. Each of the stopcock output ports is connected to one of the manifold input ports, and each of the stopcock input ports is connected with one end of a hollow glass tube, and the other end of the hollow glass tube is connected to a ground glass joint. The output ports of the manifold are terminated to a ground glass joint. Each stopcock is fitted with a plug comprising a longitudinally-movable gate whose position is driven by a stepper or D.C. electrical motor where the gate position can be monitored by a sensor and can be computer-controlled.

An object of the present invention is to provide an analysis apparatus in which local analysis of a substrate with ICP-MS is automated. The present invention relates to an automatic analysis apparatus for a local region of a substrate, including: a nozzle for local analysis having: analysis-liquid supply means that ejects analysis liquid onto a substrate; analysis-liquid discharge means that takes the analysis liquid including an object to be analyzed from the substrate into the nozzle to feed the analysis liquid to a nebulizer; and exhaust means including an exhaust channel in the nozzle; automatic liquid-feed means that automatically feeds the collected analysis liquid to ICP-MS; flow adjustment means that adjusts the flow of the analysis liquid; and automatic control means that simultaneously performs local analysis and analysis of the object to be analyzed with the ICP-MS to perform automatic analysis to a plurality of adjacent predetermined regions, successively.