A light beam guided liquid delivery device, including: a liquid delivery device; a light beam generator; and a bracket coupling the light beam generator to the liquid delivery device such that a beam of light is selectively delivered approximate to a tip of the liquid delivery device. The bracket couples the light beam generator to the liquid delivery device at a first attachment point. The bracket includes one or more hinges at the first attachment point for varying the orientation of the light beam generator. Optionally, the bracket also couples the light beam generator to the liquid delivery device at a second contact point. The bracket includes a support member at the second contact point for varying the orientation of the light beam generator. Optionally, the support member is translatable with respect to the one or more hinges along a length of the bracket.

A fluidic system that includes a reagent manifold comprising a plurality of channels configured for fluid communication between a reagent cartridge and an inlet of a flow cell; a plurality of reagent sippers extending downward from ports in the manifold, each of the reagent sippers configured to be placed into a reagent reservoir in a reagent cartridge so that liquid reagent can be drawn from the reagent reservoir into the sipper; at least one valve configured to mediate fluid communication between the reservoirs and the inlet of the flow cell. The reagent manifold can also include cache reservoirs for reagent re-use.

A multi-actuated micro-pipette controller is actuated in at least three different ways. First, the multi-actuated micro-pipette controller may be employed similar to a striper for denudation of cumulus cells and transfer of oocytes and embryos by depressing an actuator assembly operably coupled to a ballonet. Second, the multi-actuated micro-pipette controller may be actuated similar to a SWEMED™ denudation pipette by pressing directly on the ballonet while it is seated in a primary housing and a secondary housing, without employing an actuator assembly of the primary housing. Third, the multi-actuated micro-pipette controller may be actuated by removing the ballonet and employing it similar to a PASTEUR™ pipette.

Disclosed are methods and devices for detection of ion migration and binding, utilizing a nanopipette adapted for use in an electrochemical sensing circuit. The nanopipette may be functionalized on its interior bore with metal chelators for binding and sensing metal ions or other specific binding molecules such as boronic acid for binding and sensing glucose. Such a functionalized nanopipette is comprised in an electrical sensor that detects when the nanopipette selectively and reversibly binds ions or small molecules. Also disclosed is a nanoreactor, comprising a nanopipette, for controlling precipitation in aqueous solutions by voltage-directed ion migration, wherein ions may be directed out of the interior bore by a repulsing charge in the bore.

A device and method for purification of information or particles from a sample and provides a device for performing washing steps in automated analyzer systems, the device comprising a multilayer unit with liquid channel and valves. The multilayer unit may comprise three layer.

Disclosed is a reaction method that includes a reaction process using a pipette tip to allow substances to cause a reaction, the method including: providing a heater for heating the pipette tip in accordance with a preset temperature; attaching the pipette tip to a pipette nozzle and heating the pipette tip by a first preset temperature; when a period of heating by the first preset temperature exceeds a preset period, switching an output of the heater from the first preset temperature to a lower second preset temperature; detecting a distal end position of the pipette tip at or after the switching; and executing the reaction process while controlling the distal end position of the pipette tip with reference to the detected distal end position, in which the temperature of the pipette tip is kept by the second preset temperature at least until operation of the pipette tip.

Methods and apparatus to reduce biological carryover using induction heating are disclosed herein. An example method includes washing an aspiration and dispense device. The example method includes generating an alternating electromagnetic field and introducing the aspiration and dispense device into the alternating electromagnetic field. The example method includes inductively heating the aspiration and dispense device with the alternating electromagnetic field. In the example method, the washing is to occur in concert with the heating.

A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.

According to the present invention, a packing member (20) is disposed between a mouth portion (2b) of a container body (2) and a lid base portion (5). A crushing protrusion (20b) which protrudes downward and is crushed to an upper end opening edge of the container body (2) is formed on a lower surface of the packing member (20). An overhang recess (20c) which is at least partially located just above the crushing protrusion (20b) is formed on an upper surface of the packing member (20). After the lid base portion (5), the movable lid portion (6) and the syringe tube (8) are detached from the container body (2), when mounting again, until a crushing protrusion (20b) is crushed, the packing member (20) forms a communication gap (30) between the mouth portion (2b) of the container body (2) and the packing member (20).

A collection pipette that collects a microscopic object includes a first tube part, a second tube part connected to an end of the first tube part, and a third tube part connected to the other end of the first tube part. The longitudinal direction of the third tube part intersects with the longitudinal direction of the first tube part, and is parallel to the longitudinal direction of the second tube part. For example, the length in the longitudinal direction of the third tube part is shorter than the length in the longitudinal direction of the first tube part.