This pipette tip includes: a first part having an outer diameter which increases gradually from a distal end side toward a proximal end side; a second part in which a taper angle of an outer surface of the second part is smaller than a taper angle of an outer surface of the first part; a third part in which a taper angle of an outer surface of the third part is larger than the taper angle of the outer surface of the first part; and a fourth in which a taper angle of an outer surface of the fourth part is smaller than the taper angle of the outer surface of the third part.

The invention relates to an arrangement (10) for preparing a plurality of samples for an analytical method, comprising a carousel (14) with a solid housing (12) and moveable receiving parts (16) for the sample containers (18); a control for controlling the receiving parts (16) in the carousel (14); and a sample receiving device (24) for providing the sample to be analysed; one or more stations (24, 26, 28, 30, 32) for preparing samples are provided on the carousel (14), the receiving parts (16) for the sample containers (18) of the carousel (14) can be positioned on said stations; a centrifuge (22) with pairs of opposite lying receiving parts (42) provided for the sample containers (18), and said receiving parts (42) are arranged such that they can move on the centrifuge (22) and the movements can be controlled in such a manner that the sample holder (18) can be transferred between a receiving part (16) in the carousel (14) and a receiving part (42) in the centrifuge (22).

The present invention is directed towards an apparatus and methods for a precise, fast and easy to use manipulation of beads. This method is particularly useful to carry out separation between the beads and the remaining supernants present in the fluid, maximizing the collection and purification efficiencies in tips for liquid handling.

Provided in part herein are pipette tip rack assemblies having one or more of the following features: (i) having a plurality of pipette tip receptacle plates, each plate having an array of pipette tips, stacked upon one another supported by a rack base; (ii) each plate having one or more projections from the proximal or distal surface and, optionally, orifices that oppose the projections of the next plate in the stack, and (iii) the rack base having a proximal surface with one or more orifices or projections that oppose the projections or orifices of the plate in the stack. Also provided are methods of dispensing pipette tips from pipette tip rack assemblies and manufacturing pipette tip rack assembly components.

This application relates to a sample analyzing apparatus. In one aspect, the apparatus includes a base, a connector arranged at an end of the base, and a temperature controlling member mounted on the base and configured to adjust a temperature of the connector. The apparatus may also include a controller configured to adjust heat generation of the temperature controlling member to adjust a bonding force of a pipette tip attached to a surface of the connector.

Customization of a universal reagent cartridge with a lyophilized target-specific PCR component reagent is disclosed. The universal reagent cartridge includes multiple chambers populated with predetermined non-target-specific reagents therein. A custom reagent storage device that stores a lyophilized, target-specific reagent is provided and is configured to be end user insertable into the universal reagent cartridge to customize the universal reagent cartridge with the target-specific reagent.

The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. The HTP genomic engineering platform described herein is microbial strain host agnostic and therefore can be implemented across taxa. Furthermore, the disclosed platform can be implemented to modulate or improve any microbial host parameter of interest.

A pipette for use with a pipette, tip or syringe, including a piston positioned within a cylinder comprises a pipette housing extending between an upper end and a lower end. Two parallel rods are positioned in the pipette housing, wherein one of the two parallel rods is coupled to a lifting rod. An operating element is configured to protrude outwardly from the pipette housing and be displaced relative to the pipette housing. A gear mechanism is arranged in the pipette housing and comprises a drive comprising a moveable input member and configured to be driven by the operating element, and an output comprising at least one moveable output member and configured to drive the two parallel rods. Successive displacements of the input member by the operating element are configured to alternately displace one of the two parallel rods and then another of the two parallel rods by the output member.

An easy-disconnect seal matching reservoir for connecting the microfluidic chip and the pipette. The reservoir comprises at least one first coupling unit and at least one second coupling unit. The first coupling unit includes a first end and a second end opposed to the first end, and the first end is disposed on an inlet of the microfluidic chip. The second coupling unit includes a third end and a fourth end opposed to the third end, and a pipe connected between the third end and the fourth end. The third end is coupled to the second end of the first coupling unit. The pipette can be put in the pipe via the fourth end.

The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device can be modified to allow for more flexible and robust use with the disclosed methods for a variety of medical, laboratory, and other applications. The systems, devices, and methods of the present invention can allow for effective use of samples by improved sample preparation and analysis.