A pipetting device for processing a fluid sample includes a receiving element and a pipette tip detachably arranged on the receiving element, a displacement element flow-connected to the pipette tip for generating a flow for receiving or ejecting the fluid sample. The pipetting device includes an optically transparent extension detachably arranged on the pipette tip in such a way that the extension is flow-connected to the displacement element via the pipette tip, so that the fluid sample can be received into the extension or can be ejected from the extension by the flow that can be generated by the displacement element.

Disclosed here are kits comprising pre-packed stabilizing solutions for stabilizing combinations of biomarkers demonstrating sufficient accuracy and specificity for identifying kidney injuries. Such kits can be better adapted for sample collection at a subject's dwelling, thus easing the burdensome requirement of continuous monitoring for kidney injury.

Provided herein are devices, methods, and systems for in situ gene sequencing of a target nucleic acid in a cell in an intact tissue. Methods of screening a candidate agent to determine whether the candidate agent modulates gene expression of a nucleic acid in a cell in an intact tissue are also provided herein.

A disposable diagnostic device includes a body having a first channel and a second channel spaced from the first channel. A shroud is operably fixed to the body and encloses a chamber which is configured in a hermetically sealed-off relation from the first and second channels when the device is in a non-activated first state and is in open communication with at least one of the first and second channels when the device is in an activated second state. A reactant and an inert gas are disposed in the chamber such that the inert gas protects the reactant from being exposed to contaminants when the device is in said non-activated first state. A method of constructing a disposable diagnostic device is also disclosed.

Provided is a reagent cooler that prevents occurrence of condensation and further uniforms a temperature in the cooler with low power consumption and a simple structure. The reagent cooler includes a refrigerant pipe that is disposed inside an outer wall of the reagent cooler 103 and circulates a refrigerant inside the outer wall; a blowing pipe 109 that is disposed inside the outer wall and guides outside air existing outside the reagent cooler to inside of the reagent cooler; and a blowing unit 114 that is disposed at the blowing pipe and diffuses the outside air into the inside of the reagent cooler through the blowing pipe. With the outside air cooled by the outer wall and taken into the inside of the reagent cooler, the reagent cooler is positively pressurized and the internal temperature is made uniform.

A system for preparing a thrombin serum that can include a containment device, a cage received within the containment device, a cap attachable to the containment device, an inlet port configured to introduce a non-anti-coagulated autologous blood fluid into the containment device, and an outlet port. An activator, such as glass beads, can be present within the containment device.

This device comprises: a casing with an upper surface including a sample-dripping portion receiving a liquid sample containing nucleic acid and being dripped from a nozzle; a reaction tube: outwardly projecting from an end of the casing; including a storage space therein; and being formed so as to be installed within a measurement apparatus; a filter carrying the nucleic acid contained in the liquid sample; a filter-supporting body stored within the casing to support the filter in a manner such that the filter is capable of taking: a contacting position wherein the filter contacts with the liquid sample right below the sample-dripping portion; and a reaction position wherein the filter is positioned within the storage space of the reaction tube; and absorbing material capable of taking: a press-attaching position wherein the absorbing material is press-attached to the filter in the contacting position so that the filter absorbs the liquid sample contacting therewith; and a separating position wherein the absorbing material is removed from the press-attaching position so that the filter is allowed to freely move.

Described herein are cassettes and methods for using these cassettes for cryopreserving biomaterials (e.g., a bioengineered construct or natural tissue sample) by vitrification while reducing or preventing the loss of viability associated with conventional preservation methods.

A top for a plasma storage container includes a top body that defines the structure of the top and seals an opening of the plasma storage container. The top also includes a first opening and a vent opening extending through the top body. A valve mechanism is located at least partially within the top body and includes an aperture therethrough. The aperture opens upon connection of a blunt cannula to provide access to the interior of the plasma storage container. The top also includes a vent filter. The vent filter allows air to vent through the vent opening during plasma collection.

Provided herein are systems and methods for a point of need testing system. In some embodiments, the point of need testing system includes a first collector and a sample amplifier. The first collector is configured to collect a first biofluid sample. The sample amplifier includes an inlet dimensioned to receive the first biofluid sample. The sample amplifier further includes a filter, a heater, and a second collector. In some embodiments, a reader can be used with the sample amplifier to read a second biofluid produced by the sample amplifier.