Cell separation systems, and methods for separating cells from microcarriers, and harvesting the separated cells, are provided, wherein the system comprises a cell separation device, a cell settling device, and a cell screening device.

An analysis cartridge includes a first cover, a second cover, a plurality of containers, a plurality of fluid tunnels and a rotary valve. The second cover has two opposite surfaces, a plurality of first through holes and a second through hole individually penetrate through the two opposite surfaces, and the first cover is attached to the second cover. The plurality of containers are disposed between the first cover and the second cover, with each of the containers being aligned to and filled in the first through holes. The plurality of the fluid tunnels are disposed on the first cover, and each of which is individually connected with a first pipette. The rotary valve is rotatably disposed between the first cover and the second cover to correspond to the second through hole, and a flow channel disposed on the rotary valve is connected with the containers individually.

Broadly speaking, embodiments of the present techniques provide a modular sample processing device which allows a user to perform any number of biological processes within a single device, in the order the user requires. The device is customisable—a user may select two or more modules and connect them in series to form the device in which the biological processing takes place. Advantageously, this may enable a user to perform multiple processes within a single device and potentially outside of a laboratory (e.g. during field work) or outside of sterile/aseptic environments. Furthermore, the device is a hand-held device, which means the device is compact and easy to transport and use for field work.

A method for detecting, sorting, purifying and characterizing objects of interest in a liquid sample. The method comprises preparing, in a preparation module ON) of a microfluidic router system, the liquid sample for processing. Preparing comprises transporting the sample through a microfluidic channel, and forwarding the prepared sample from an outlet of the preparation module into an inlet of a routing module. Forwarding comprises coupling a microfluidic flow between the outlet and the inlet to passively buffer against or actively compensate for variations in a flow rate of the prepared sample at the outlet, and diverting the objects of interest from the microfluidic flow. Forwarding the sample comprises sensing a flow characteristic of the sample in preparation, routing module, or in flow connection, and controlling a flow control element taking the sensed characteristic into account to compensate for a variation in the flow rate by a closed-loop flow control.

An apparatus, system, and method for filtering and assaying a fluid sample are described. In an embodiment, the apparatus includes a filtration unit comprising: a filter bracket shaped to removably couple with a fluid sample cup and a vacuum container; and a filter housing cooperatively couplable to the filter bracket and comprising a filter configured to filter fluid passing through the filter bracket; and an assay device shaped to cooperatively couple with the filter housing and comprising a porous matrix positioned to be in fluidic communication with the filter when the filter housing is cooperatively coupled with the assay device.

The present invention relates to the field of biomedical technology and discloses a cartridge and a testing device. The cartridge comprises a sample lysis compartment, a first sample mixing compartment and a first PCR compartment; a first valve is disposed between the sample lysis compartment and the first sample mixing compartment, the first valve controls the flowing or blocking of the sample between the sample lysis compartment and the first sample mixing compartment; a fourth valve is disposed between the first PCR compartment and the first sample mixing compartment, the fourth valve controls the flow or blocking of the sample between the first sample mixing compartment and the first PCR compartment; a first reagent is provided in the first sample mixing compartment. In the compartment, nucleic acids in the sample mix with the first reagent and is then sent to the first PCR compartment for amplification.

The present disclosure relates to a biological test cassette and a medical test system, the biological test cassette comprising a support, a cassette body, a chip, a first connecting tube and a second connecting tube. The support is provided with a first via hole. The cassette body is provided with a second via hole corresponding to the position of the first via hole, mounted on a top surface of the support, and further provided with a pretreatment chamber and a first flow channel in communication with the pretreatment chamber. The chip is slidably provided on a bottom surface of the support, and provided with an analyzing and processing chamber and a second flow channel in communication with the analyzing and processing chamber. The second connecting tube can be freely bent and deformed during the process of pulling the chip out from or pushing the chip back into the support.

An assembly for forming a microchamber for an inverted substrate is disclosed. The assembly can include a body having a chamber formed therein. A dispensing cavity can be provided to supply a reagent to the chamber. A slide support structure can be configured to support the slide such that the tissue sample faces the chamber when the slide is mounted to the slide support structure. The chamber and the slide support structure can be dimensioned such that, when the reagent is supplied to the dispensing cavity, the reagent is drawn to the chamber by way of capillary forces acting on the reagent.

Devices, systems, and methods for trapping and manipulating portions of tissue are described. In an embodiment, the devices include an array of traps, wherein traps of the array of traps are shaped to trap a tissue sample; and a well is in registry and fluidic communication with a trap of the array of traps.

A disposable cartridge for mitigating cross-contamination of fluid sample reagents. The disposable cartridge includes a cartridge body defining a syringe barrel having an barrel port operative to inject and withdraw assay fluids in response to the displacement of a syringe plunger. Furthermore, the disposable cartridge includes a rotor defining a plurality of assay chambers in fluid communication with the barrel port through one of a plurality of rotor ports disposed about the periphery of the rotor. Finally, the disposable cartridge includes a flow control system between the barrel and rotor ports which prevents cross-contamination of fluid sample reagents from one assay chamber to another assay chamber.