Diagnostic detection chip device designs that reduce cost of fabrication and assembly are described herein. Such chip device designs include features that facilitate use of the chip within a chip carrier device with integrated fluid flow control features and compatibility with conventional sample cartridges and sample processing systems. Associated methods of manufacture and assembly of the chip devices are also provided herein.

Systems, methods, and apparatus are provided for external control testing of an assay system.

A fluid laying device includes a manifold block. The manifold block defines a first channel, and also defines a first fluid inlet, a first fluid outlet, and several carrier interfaces. Each carrier interface has a first hole connecting one of a channel inlet and channel outlets of the flow cell carrier. The manifold block is provided with an inlet valve device, a bypass valve device, and outlet valve devices. The inlet valve device and the outlet valve devices are one-to-one corresponding to the carrier interfaces, and disposed on a fluid path from the corresponding carrier interface to the first channel. The first channel includes a first section and a second section. A bypass valve device is between the first and second sections to control connection and disconnection between the first and second sections. The inlet valve device connects the first section, and the outlet valve devices connect the second section.

A discoid sample holder (1), on which a device (2) for carrying out at least one processing step is formed. According to the invention, a slot (3), into which a sampling instrument (4) can be introduced, and a mechanism (5) for releasing a sample from the sampling instrument (4) arranged in the receptacle (3), is formed in the sample holder.

An insulated shipping container system for transporting temperature sensitive specimens includes an insulated body, an insulated lid, and a stretchable strap. The insulated body has an internal cavity that is accessible through an opening and has a cross-sectional shape. The insulated lid is configured for selectively closing the opening to the internal cavity when the lid is in a closed position. The stretchable strap is removably attachable to each of the insulated body and the insulated lid. The stretchable strap is configured to stretch and attach to a lug on the insulated body to selectively hold the insulated lid in the closed position and further configured to retain the insulated lid to the insulated body when the lid is in an opened position. The insulated shipping container system may also include a freezable cold pack having a shape corresponding to the cross-sectional shape of the internal cavity.

The present technology is directed to extraction devices, systems, and methods for controllably withdrawing and transferring fluid samples, such as blood, from a sample collection container to a testing device. For example, some embodiments of the present technology provide fluid extraction devices that include a fluid control module, a housing containing a receiving element and a suction element, and an actuator. To transfer blood from a sample collection container to a testing device, a user places the sample collection container over the receiving element and inserts the testing device into an outlet of the fluid control module. The user then pushes a lever or otherwise actuates the actuator, which automatically withdraws a predetermined volume of blood from the sample collection container and transfers it to the testing device positioned at the outlet of the fluid control module.

Embodiments of the invention relate to devices for assaying a biomolecule from a plant sample including: a microfluidic cartridge for assaying a biomolecule from a plant sample, including: a top layer; and a bottom layer spaced apart from the top layer in a generally parallel orientation with respect to the top layer, the bottom layer defining a plurality of wells therein that protrude from a surface of the bottom layer; and a filter module for filtering the plant sample, including a filter body defining: an upper portion including an inlet structure forming an inlet channel; and a bottom portion configured to accept and secure a filter membrane. The filter body is configured to accept a microvolume aliquot of the plant sample, the bottom structure includes an outlet structure forming an outlet channel on an outlet side of the filter membrane, and at least one of the plurality of wells includes an assay reagent solution.

A device for storage and transport of biological samples. Multiple trays are assembled into a stack with sample tubes constrained between adjacent trays. The surface of each tray has radial grooves sized to hold the sample tubes. Each tray is secured to an adjacent tray with a bolt or snap-fit connector.

A modular fluid chip according to an embodiment of the present disclosure includes a body including at least one first hole which allows fluid to flow therethrough; and a housing receiving the body therein, and including a second hole which corresponds to the at least one first hole and allows the fluid to flow therethrough, and a fluid connection part which is connectable to another modular fluid chip.

A cartridge can comprise a first elastomeric membrane and a second elastomeric membrane, and portions of the elastomeric membranes which are sealed to each other can circumscribe unsealed portions of the membranes. In a resting state, the unsealed portion of the first elastomeric membrane abuts or is proximate to the unsealed portion of the second elastomeric membrane. One or more reagents can be injected between the unsealed portions of the first and second elastomeric membranes to push the unsealed portions apart from each other in this region of the membranes. The unsealed portions can be sequentially pushed apart in downstream regions to form a channel between the elastomeric membranes. Positively displaced fluid pushes the unsealed membrane portions apart to a volume that conforms to the volume of the fluid to minimize or prevent dead volume in the channel and thus minimize or prevent air bubbles in the fluid.