A microfluidic device for detection of an analyte in a fluid is described. The microfluidic device comprises a substrate having a first surface defining entrances to one or more chambers defined in the substrate, surfaces of the chambers defining a second surface of the substrate, the first surface being modified for selective targeting and capture of at least one analyte to operably effect a blocking of the entrance to at least one of the chambers, and wherein a response characteristic of the microfluidic device is operably varied by the blocking of the entrance to the at least one of the chambers, thereby providing an indication of the presence of the analyte within the fluid.

A microfluidic group includes a female connector and a male needle connector. The female connector has a connector chamber in a containment body; a duct extending in the containment body to a duct opening on a first face of the connector chamber; a needle entry hole extending from a lateral face of the containment body to a second face, not facing the first face of the connector chamber; and a gasket arranged in the connector chamber. The gasket has a side wall internally delimiting a cavity and extending in part adjacent to the second face of the connector chamber. The cavity of the gasket faces the first face of the connector chamber.

A microfluidic group includes a female connector and a male needle connector. The female connector has a connector chamber in a containment body; a duct extending in the containment body to a duct opening on a first face of the connector chamber; a needle entry hole extending from a lateral face of the containment body to a second face, not facing the first face of the connector chamber; and a gasket arranged in the connector chamber. The gasket has a side wall internally delimiting a cavity and extending in part adjacent to the second face of the connector chamber. The cavity of the gasket faces the first face of the connector chamber.

The present invention relates to a microfluidic system (10, 20) comprising: a sample reservoir (110, 210); a first sample channel (120, 220) connected to the sample reservoir (110, 210), branching off into a second sample channel (122, 222) ending in a first valve (130, 230), and into a third sample channel (124, 224) which branches off into a fourth sample channel (126, 226) ending in a second valve (132, 232), and into a fifth sample channel (128, 228) ending in a third valve (134, 234); a buffer reservoir (140, 240); a first trigger channel (150, 250) arranged to connect the buffer reservoir (140, 240) to the second valve (132, 232); a second trigger channel (152, 252) connecting the second valve (132, 232) and the first valve (130, 230); and an exit channel (154, 254) connected to the first valve (130, 230).

A second device includes a first surface, a second surface in contact with a first device, and a first hole extending through and between the first surface and the second surface and being continuous with a groove on the first device. A third device includes a third surface in contact with the first surface, a second hole open in the third surface and continuous with the first hole, and a flow path continuous with the second hole and open in the third surface. As viewed in a first direction from the first surface to the second surface, the first hole includes at least one vertex surrounded by the second hole, and a pair of sides joined to the at least one vertex and widening toward the flow path to define a minor angle.

An automatic nucleic acid extraction cartridge and an automatic nucleic acid extraction system including the same are described herein. The cartridge having a housing that includes a sample port, a cell processing chamber, a wash fluid chamber, a filter assembly comprising a filter member, and a diverter valve having a first and a second reversibly sealable output, wherein each of the sample port and the cell processing chamber, the cell processing chamber and the filter assembly, and the wash fluid chamber and the filter assembly are in one-way fluid communication, and the filter assembly is in fluid communication with the diverter valve and (i) a waste conduit when the diverter valve is biased to the first reversibly sealable output and (ii) a pathogen nucleic acid conduit when the diverter valve is biased to the second reversibly sealable output. The present disclosure further describes methods of using the same.

A sensing system is disclosed. The sensing system includes a sensor cartridge and a readout device. The sensor cartridge includes a sensing device and a micro-channel-structure. The sensing device includes a chip member and an electrode member arranged projectively offset from each other.

A fluidic device for detecting a target molecule in a fluid sample comprising a blocking chamber in fluidic communication with a detection chamber forming a blocking-detection chamber pair, the blocking chamber provided with at least one reagent for binding a non-target molecule in the sample, the blocking chamber adapted to maintain at least a portion of the bound non-target molecule within the blocking chamber, the detection chamber comprising at least one reagent for binding a target-molecule such that the target-molecule may be detected. The device comprises a combination detection chamber adapted to receive at least one reagent for binding both target and non-target molecules such that the combination of target and non-target molecules may be detected by binding to a detector.

The present embodiments relate to a fluid control device using centrifugal force. The fluid control device using centrifugal force includes a fluid control portion comprising a plurality of chambers and controlling a movement of a fluid inside the chamber; a lower fixing portion positioned on a lower portion of the fluid control portion and fixing the plurality of chambers; an upper fixing portion positioned an on upper portion of the fluid control portion and fixing the plurality of chambers; and a fastening member penetrating and fastening the lower fixing portion, the fluid control portion, and the upper fixing portion, wherein the plurality of chambers are disposed to face each other and placed on the lower fixing portion.

A millifluidic device for cultures of biological agents comprising: a main body (11) comprising at least a first hole (40) closed at the bottom; a separator (35); a membrane (36) fixed to said separator (35); a plug (15) closing said first hole (40); said separator (35) designed to be placed in said first hole (40); said separator (35) being extractable from said first hole (40); said membrane (36) divides said first hole (40 ) into an upper half-chamber and a lower half-chamber; a pair of tubes (25) to perfuse said lower half-chamber; a pair of tubes (26) to perfuse said upper half-chamber; a first slide (22) placed centrally on said plug (15); a second slide (42) placed centrally on said first hole (40); a cylindrical body (41) rises from said first hole (40) and said second slide (42) is placed on the top of said cylindrical body (41); said cylindrical body (41) has a second hole (43), coaxial to said cylindrical body (41).