Fluidic modules configured for flowing fluid through membranes and associated methods are generally provided. In some embodiments, a fluidic module comprises two channels between which a membrane is positioned. The two channels may have geometries such that the pressure drop experienced by a fluid flowing from the first channel, through the membrane, and into the second channel is substantially independent of the location along the channel at which it flows through the membrane. In other words, the pressure drop may be substantially constant over the membrane area.

Embodiments disclose an apparatus and methods for biological sample processing enabling isolation and enrichment of microbial or pathogenic constituents from the sample. A vessel for sample containment and extraction is further disclosed for engagement with a transducer capable of efficient sample disruption and lysis. Together these components provide a convenient and inexpensive solution for rapid sample preparation compatible with downstream analysis techniques.

A biochip and a method for manufacturing the same are provided. The biochip includes: a guide layer; a channel layer on the guide layer, wherein the channel layer has therein a plurality of first channels extending in a first direction; a plurality of second channels extending in a second direction, wherein each of the plurality of second channels is in communication with the plurality of first channels, the plurality of second channels are in a layer where the channel layer is located, or in a layer where the channel layer and the guide layer are located; an encapsulation cover plate on a side of the channel layer distal to the guide layer; and a driving unit configured to drive biomolecules to move.

A well plate includes a including a top portion, a bottom portion and a membrane disposed between the top portion and the bottom portion. The top portion defines a sample well in fluid communication with an opening defined by the membrane and in fluid communication with a reservoir defined by the bottom portion. The well plate is configured to be used in a centrifugation process of a test sample including a sample material and a wash liquid. The test sample configured to be received within the sample well and the reservoir. The membrane configured to filter the wash liquid from the test sample during the centrifugation process such that the wash liquid can pass from the reservoir, through the membrane and can be captured within a collection chamber while the sample material remains within the reservoir.

The present invention relates to an apparatus (1) and method (2) for automatically preparing liquid-based cytology (LBC) slides (107) by means of filtration comprising of at least one substrate (101) for holding a vial (103) containing specimen, a filter (105) and a slide (107) wherein said substrate (101) is located at a first station (FS); at least one working station (WS) comprises of a working platform (109) connected to said first station (FS) wherein said first station (FS) includes a vertical rotary conveyor system (121) which is flexible, user friendly and capable of providing uniformity of the cell distribution in the homogenous thin-layer LBC slides (107) as well as increase system throughput.

A device for separation and/or preservation of non-cellular components from a biofluid sample includes at least one separation member to separate the non-cellular components from the sample and to retain cellular components, at least one extraction member to permit extraction of the non-cellular components from the separation member, at least one flow assay to analyze the non-cellular components extracted, and a housing in which the separation member, the extraction member and the flow assay are arranged. The housing is configured to be shifted from a first configuration to a second configuration In the first configuration, the separation member and the extraction member are fluidly coupled so that the device is configured to extract the non-cellular components In the second configuration, the separation member and the extraction member are fluidly uncoupled to prevent a preservative added to the separation member from reaching the extraction member and/or the flow assay.

A manually actuated chromatography device comprising a chamber for receiving a liquid sample, a pump with a metering valve, and a chromatography element, wherein the pump moves a predetermined volume of liquid from the sample chamber to the chromatography element.

A device for collecting contaminants from water samples is provided. The device includes a solid sorbent that collects and stores the contaminants from water samples. The solid sorbent is configured to allow for the preservation of the stored contaminants. The concentrations of the contaminants in the water samples are determined via analysis of the solid sorbent or via elution of the stored contaminants from the sorbent and analysis of the eluate solution.

A microfluidic device, particularly of the lab-on-chip type, for the detection of biological and/or medical targets of interest in biological samples, as well as for the operations of extraction of such targets from native or non-native biological samples, of purification, concentration, and injection in buffer solutions, all adapted to optimize the detection thereof.

Analytical cartridges, systems and methods of processing a sample for analysis using capillary flows. Vertical gradient sample filtration provides filtrate to an incubation chamber for a time controlled by a flow modulator at the outlet of the incubation chamber. The flow modulator can include a serpentine capillary flow path without side walls. Incubated filtrate can flow from the incubation chamber to a detection channel after a predetermined time. The detection chamber can include one or more analytical regions in a porous substrate for detection of two or more analytes on the same cartridge from the same sample.