A particle measuring device has an upper surface having a first flow inlet to receive a first fluid containing target particles to be measured, a first flow path connected to the first flow inlet to allow measurement of the target particles, and a third flow path located upstream from and connected to a joint between the first flow path and the first flow inlet and having a smaller width than the first flow inlet. The first flow path includes a first planar portion having a greater width than the third flow path and the first flow inlet, a width-increasing portion located downstream from and connected to the first planar portion, and a second planar portion located downstream from and connected to the width-increasing portion.

The present invention is related to the field of microfluidics and compound distribution within microfluidic devices and their associated systems. In one embodiment, present invention aims to solve the problem of molecule and compound absorbency into the materials making up laboratory equipment, microfluidic devices and their related infrastructure, without unduly restricting gas transport within microfluidic devices.

The disclosure relates to a method and a system for automated handling of a pipette. The system may include an identifying device for identifying the pipette, a robot being configured to perform a handling operation on the pipette, and a control unit. The control unit may be configured to obtain data related to the pipette from a database. The control unit may also be configured to obtain data from one or more of the identifying device and the robot.

A particle separating and measuring device includes a first flow path device having a post-separation flow outlet to allow discharge of a first fluid containing target particles to be separated, and a second flow path device receiving the first flow path device and having a first flow inlet to receive the first fluid. The first flow path device having a lower surface having the post-separation flow outlet is on the second flow path device having an upper surface having the first flow inlet in a first region, with the post-separation flow outlet facing and connecting to the first flow inlet. A connection flow path vertically extends from an opening of the first flow inlet to a first flow path, and narrows from the opening of the first flow inlet toward the first flow path.

The present invention relates to an automatic real-time label-free holography-activated sorting of the cell's technique. The technique provides high-discriminative power on the level of the individual cell. The technique includes rapid automated cell processing during cell visualization and flow, with high discriminative power on the level of the individual cell. The technique may be useful in detection of cancer and to identify different stages of oncogenesis.

In order for it to be possible for the user of a manual metering apparatus (1) to be provided with different options for adjusting a manual metering apparatus (1), in particular a pipette, the manual metering apparatus (1) according to the invention is proposed, in the case of which the operating element (5) for operating the volume adjusting mechanism (3) of the manual metering apparatus (1) is constructed in two pieces and comprises a display adjusting element (7) which is connected to the volume display (4) of the manual metering apparatus (1), and the volume adjusting element (8) which is connected to the volume adjusting mechanism (3) of the manual metering apparatus (1). The display adjusting element (7) and the volume adjusting element (8) are connected to one another via the releasable coupling (9), with the result that a volume adjustment leads to a corresponding adjustment of the volume display and vice versa, as long as the coupling (9) is closed. If the coupling (9) is released, the display adjusting element (7) and the volume adjusting element (8) can be adjusted or actuated independently from one another in order to adjust the manual metering apparatus (1) (FIG. 5).

Various methods, devices, and systems for determining the concentration of microorganisms in a sample and determining the susceptibility of such microorganisms to one or more antibiotics or other types of anti-infectives are disclosed herein. More specifically, methods for quantifying microorganisms based on redox reactions are disclosed along with systems and devices for quantifying such microorganisms using certain oxidation reduction potential (ORP) sensors. Moreover, methods for determining the susceptibility and the degree of susceptibility of microorganisms to one or more anti-infectives are disclosed along with multiplex systems for such assays.

One aspect of the present invention is to provide systems and methods that improve the accuracy of an assay that comprise at least one or more parameters each having a random error.

A microdevice includes a plurality of calibration curve liquids, a plurality of first microchannels respectively filled with the plurality of calibration curve liquids, at least one second microchannel filled with a measurement target liquid, and a sealing member that closes openings of the first microchannels to seal the calibration curve liquids. Each of the calibration curve liquids includes a measurement target substance of a predetermined concentration, the predetermined concentration in each of the plurality of calibration curve liquid being mutually different, an antibody that specifically binds to the measurement target substance, and a fluorescent-labeling derivative that fluorescently labels the measurement target substance and competes with the measurement target substance to specifically bind to the antibody. The measurement target liquid includes an unknown concentration of the measurement target substance, the antibody, and the fluorescent-labeling derivative.

A liquid evaluation system can include a cartridge including a channel configured to pull a liquid into the channel by capillary action. The cartridge can include an upper plate and a lower plate located in close proximity to the upper plate. The lower plate includes a deposition region for dispensing liquid. The extent of the deposition region in one or more directions can be defined by a repellant barrier, such as a boundary with a set of areas configured to be repellant to the liquid. An internal facing surface of each plate can include a corresponding region forming the channel. Each of the regions can be configured to have an affinity for the liquid. The close proximity of the plates and the regions having an affinity for the liquid cause the liquid to be pulled into the channel by capillary action.