Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

A smart instrument for mixing (100), a microfluidic chip (50), and a system wherein they are used to prepare formulations is provided. The microfluidic chip comprises microchannels and a programmable data component. The system achieves optimal formulations for RNA, antisense, peptides and small molecules in the hands of even novice users.

A detection analyzer including a first sample input/output element, a second sample input/output element, a sample compartment, a vibration platform, a vibration generator, a data acquisition system, a laser converter, and a data display. The first sample input/output element and the second sample input/output element are each connected to the sample compartment; the vibration platform is located inside the sample compartment; the vibration generator is located outside the sample compartment, and the vibration platform is connected to the vibration generator; the data acquisition system is located outside the sample compartment, and is connected to the vibration platform; and the data display is connected to the data acquisition system.

A microfluidic system includes a flexible substrate having a skin-facing surface and a back-facing surface; a microfluidic network at least partially embedded in or supported by the flexible substrate; a sensor fluidically connected to the microfluidic network, wherein the microfluidic network is configured to transport a biofluid from a skin surface to the sensor; and a capping layer, having a capping layer skin-facing surface and a back-facing surface, wherein the back-facing surface of the capping layer is attached to the skin-facing surface of the substrate. The flexible substrate is at least partially formed of a thermoplastic elastomer or a polymer configured to provide a high barrier to vapor or liquid water transmission.

Analysis systems and methods for testing a biological sample is provided, wherein the inclination is monitored and/or a light strip is provided as a display apparatus that signals an operating state or a requirement.

The automatic analyzer includes a control unit provided with a determination unit which determines requirement or non-requirement of the calibration executed to the loaded reagent when the reagent ID reader identifies the reagent, a request generation unit which makes a notice of a standard solution necessary for the calibration when the determination unit determines requirement of the calibration, and generates a calibration request when loading of the standard solution is detected, and a planning unit which makes a plan of the carry-in and the calibration to execute the calibration as required immediately after the carry-in of the reagent into the reagent disc. This makes it possible to lessen the process to be performed by the user until the reagent is made available for measurement of the patient specimen.

The present disclosure relates to retractable diagnostic devices, and hybrid diagnostic devices comprised of water-dispersible, flushable, biodegradable, or water-soluble material and non-water-dispersible, non-flushable, or non-water-soluble material.

Apparatus (2) for testing a liquid specimen (4), which apparatus (2) comprises: (i) a collection container (6) for collecting the liquid specimen (4); (ii) a test container (8) for testing the liquid specimen (4); (iii) response portions (10) which are in the test container (8) and which are for responding to contact with the liquid specimen (4) to give at least one test result; and (iv) transfer means (12) which enables the collection container (6) to be connected to the test container (8) for transferring at least some of the liquid specimen (4) from the collection container (6) to the test container (8) such that the transferred liquid specimen (4) is able to contact the response portions (10) in the test container (8) and enable the response portions (10) to react to the liquid specimen (4) for the testing and characterised in that: (V) the apparatus (2) is such that the liquid specimen (4) is transferred from the collection container (6) to the test container (8); (vi) the apparatus (2) is such that the container (8), whereby the liquid specimen (4) that has been transferred to the test container (8) and that has been used by the response portions (10) in the test container (8) is able to be tested with or without the collection container (6) being present.

Embodiments of the invention comprise a test strip configured to detect one or more metabolites of progesterone in urine, and optionally further detect one or more additional metabolites or hormones in urine within the same test strip. Embodiments of the invention are methods of utilizing such a test strip in association with avoidance of pregnancy, detection of menopause, and in association with fertility planning purposes. Embodiments of the invention are associated with the incorporation of a test strip within a testing kit, optionally further comprising a digital reader.

An analytical toilet, comprising: a bowl adapted to receive excreta; one or more conduits for transporting a sample from the bowl; one or more fluid sources in fluid connection with the one or more conduits; and one or more microfluidic chips, comprising: at least one microfluidic fluid inlet channel; and a sensor configured to detect at least one property of an excreta sample is disclosed.