This present disclosure provides devices, systems, and methods for performing point-of-care analysis of a target analyte in a biological fluid via a binding assay. The present disclosure includes a cartridge for collecting the target analyte contained in a fluid sample and performing an assay. The cartridge includes an assay stack having a first separation layer, a second separation layer, and a detection membrane. The cartridge also includes a plurality of first complexes comprising a capture molecule and a magnetic bead and a plurality of second complexes comprising a detection molecule and a detection label. Further, the detection membrane includes a substrate that interacts with the detection label to elicit a quantifiable response in the presence of the target analyte. The quantifiable response corresponds to an amount of detection antibody present in the detection membrane, and the amount of detection antibody present corresponds to an amount of the target analyte present.

The present disclosure provides a microfluidic device, including a bottom substrate, an electrowetting-on-dielectric (EWOD) chip, a circuit board, a dielectric film, and a motor. The EWOD chip is disposed on the bottom substrate, and the circuit board is arranged on the EWOD chip. The circuit board includes a circuit area that is electrically connected to the EWOD chip, and the empty area is adjacent to the circuit area and the EWOD chip is exposed. The dielectric film is disposed on the empty area of the circuit board and covers the exposed EWOD chip. The motor is disposed under the bottom substrate, and one end of the motor has a magnetic structure, so that the magnetic structure can move closer to or away from the bottom substrate.

The invention relates to a device (1) for analyzing biological samples (S) comprising a substrate (2) for receiving a biological sample (S), wherein the substrate (2) comprises or consists of a fibrous material (F) configured to form a stationary phase which retains molecules in a biological sample (S) dissolved in a liquid mobile phase depending on molecular weight and/or polarity of the molecules, a first electrode (41) and a second electrode (42), which are arranged along a first axis (A1) and configured to generate an electric field acting along the first axis (A1) when an electric potential difference is provided between the first electrode (41) and the second electrode (42), so that charged molecules contained in the biological sample (S) are movable through the substrate (2) along the first axis (A1) and/or separable by their molecular weight, their polarity and/or their charge, wherein the substrate (2) comprises a chemical lysing agent (L) capable of lysing the biological sample (S). Furthermore, a method for analyzing biological samples (S) using the device (1) is provided.

The present disclosure relates to water dispersible or soluble diagnostic assay methods, devices, kits, and methods of manufacture.

A test tube rack having at least one perforated surface for the insertion of tubes that are held in a vertical position is disclosed. The rack being formed by at least one first pre-cut cardboard sheet is provided with fold lines that, prior to use, defines a laminar body having a minimal thickness, and, at the time of use, it may be assembled to form a volumetric body having at least one upper platform including perforations and maintaining the vertical position of the tubes inserted into the perforations, in turn, can be adjusted to the diameter of the tube as to receive tubes of different diameters. The test tube rack may have a second lower platform with perforations positioned in vertical alignment with the perforations in the upper platform that the tubes inserted therein are gripped at two heights.

Disclosed is a device and method for a microfluidic paper-based analytical device (μPAD), for low-cost and user-friendly analytical devices capable of use for disease screening, point-of-care pathogen and biomarker detection, food and water quality testing. A microfluidic paper-based analytical device is further produced by chemical vapor deposition for multiplex heavy metal detection in water. Assay demonstrations proved that the immobilization of functional groups and multiplex heavy metal detection is suitable for real-world applications and established the approach for DNA analysis. The disclosed invention comprises multilayer capability, including the ability for various biomolecules to be immobilized with charge interaction.

A method of detecting a pathogen in a water sample. The method includes extracting DNA of the pathogen from a DNA solution derived from a water sample, eluting the DNA through a paper-based microfluidic device having flow channels and then performing LAMP reactions within a set of reaction chambers to obtain LAMP products that may be detected via an amplicon detection test.

The application is related to a test tube rack, and the test tube rack comprises a first supporting surface and a second supporting surface. The test tube rack further comprises a first hole used for inserting a test tube. The first supporting surface and the second supporting surface can be folded. Such test tube rack can be subject to folding shrink packaging when being packaged and is opened when being used, so that a test tube is inserted to operate.

A container for collecting a sample is provided that can include a housing, an enclosure pivotally coupled to and slidably engaged with the housing, and a sample holder slidably engaged with and received within the enclosure. The sample holder can include a substrate configured to receive the sample. The container in a first configuration can include the enclosure being engaged with the housing to enclose and seal the substrate within an interior volume of the container. The container in a second configuration can include the enclosure exposing the substrate to the ambient environment.

Lateral flow devices, methods and kits for performing lateral flow assays are provided.