Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits radiation; at least one element for directing the emission radiation in a particular direction; and a light path along which the emission radiation travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the integrated device. Each sensor may detect emission radiation from a sample in a respective sample well. The instrument includes an excitation light source for exciting the sample in each sample well.

Embodiments of the present disclosure provide a device for manipulating a substance, the device comprising at least three series of interdigitated electrode pairs, wherein each electrode of each pair is connected to an electrode in an adjacent pair in the respective series by an electrical path, and a dielectric layer disposed on the at least three series of interdigitated electrode pairs, the dielectric layer comprising one or more sub layers. The at least three series of interdigitated electrode pairs are selectively and independently energisable to produce an electric field at a top surface of the dielectric layer so that a substance on the top surface may be manipulated by the electric field. The device further comprises one or more groups of the interdigitated electrode pairs, each group having a longitudinal axis, wherein in each group the respective interdigitated electrode pairs are arranged along the respective longitudinal axis such that along the respective longitudinal axis no two adjacent pairs are from a single one of the at least three series, and no pair is adjacent to two other pairs from a single one of the at least three series.

An array device including a base having wells, a cover positioned over the base with a gap from the base such that openings of the wells are covered by the cover with the gap in between, an injection port communicating with the gap, a discharge port communicating with the gap and positioned apart from the injection port, and a waste liquid vessel which collects liquid that flows from the gap via the discharge port and is positioned at a level different from the gap forming a channel. The discharge port is placed to discharge a surplus aqueous solution outside the wells from the discharge port by an oleaginous sealing liquid to be delivered from the injection port.

A mobile device based multi-analyte testing analyzer for use in medical diagnostic monitoring and screening, and a method of manufacturing the same are disclosed. A reflectance based, colorimetric test strip reader for use with a mobile device having a jack plug receiving socket, said test strip reader adapted for removably receiving a test strip having a test strip longitudinal axis, comprising a housing; a jack plug operably coupled to and extending from said housing and adapted for operable coupling with said jack plug receiving socket; a test strip adapter including structure defining a test strip receiving channel; a light source oriented within said housing for directing light toward said test strip receiving channel to illuminate a test strip arranged within said test strip adapter; and a light sensor oriented within said housing to sense light reflected from a test strip carried by said test strip receiving channel.

The invention provides novel sample chambers, units and multi-well plates, and systems and methods thereof, for built-in measurement assurance of cell counting methods and calibrated and/or quality-assured measurement and analysis of diverse types of biological cells, e.g., cell count, cell size, cell concentration, cell sub-population, cell morphology, cell viability, etc.

A specimen collection, storage, transport, and testing device can include an outer vessel containing an internal cup having an openable drain having a brim raised above the bottom floor of the cup. Once opened the drain allows a portion of liquid specimen to flow from the cup into a lower chamber of the vessel containing a number of chromatographic assay strips. A lid sealing the vessel can include a downwardly projecting guide tube having first barrier sealing a bottom aperture. An oblong initiator can axially engage the guide tube, break the first barrier and open the drain to initiate the test while retaining a pool of liquid specimen in the cup for subsequent confirmatory testing.

A gene amplification chip may include a substrate; a through-hole array including through-holes that extend from an upper surface of the substrate to a lower surface of the substrate and in which a gene amplification reaction occurs; and a photothermal film provided on at least one of the upper surface and the lower surface of the substrate and configured to generate heat using light.

A fluid handling device includes a channel including a roughened surface that causes irregular reflection of light. A fluid handling system includes the fluid handling device, an irradiation part for irradiating the roughened surface of the channel with light, and a light detection part for detecting light reflected by the roughened surface or light transmitted through the roughened surface after irradiation from the light irradiation part.

A microdevice includes: a microchannel to which a measurement target solution containing a measurement target substance is introduced; an antibody being fixed to at least one sidewall surface of the microchannel and specifically binding to the measurement target substance; a fluorescence-labeled derivative being specifically bound to the antibody and being acquired by fluorescence-labeling the measurement target substance; and a light blocker blocking excitation light exciting fluorescent light radiated by the fluorescence-labeled derivative. The measurement target substance and the fluorescence-labeled derivative specifically bind to the antibody in a competitive manner, and the antibody is fixed to the sidewall surface of the microchannel in a state of specifically binding to the fluorescence-labeled derivative. The light blocker blocks the excitation light entering the fluorescence-labeled derivative specifically binding to the antibody.

A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.