A microfluidic system for separating biological entities includes a cooling device including a thermoelectric heat pump, a first fan, and a first heat exchanger disposed between the first fan and the thermoelectric heat pump; a first housing structure having a first shell that encases the first fan and the first heat exchanger; a microfluidic device and one or more piezoelectric transducers attached thereto; and a second housing structure reversibly attached to the first housing structure and having a second shell that encloses therein the microfluidic device and the one or more piezoelectric transducers. When the first and second housing structures are coupled, a first air passage is formed between a side of the first heat exchanger and an end of the microfluidic device, a second air passage is formed between the first fan and the piezoelectric transducers, thereby allowing air to circulate between the first and second air passages.

The present disclosure discloses an electronic cooling anti-condensation system, and an anti-condensation method for the same. The system comprises a testing chamber, electronic cooling plates, temperature sensors, a temperature and humidity sensor, a cooling plate control unit, and a main controller. The main controller is electrically connected to the temperature sensors, the temperature and humidity sensor, and the cooling plate control unit. The main controller is capable of calculating a dew point value of the air in the testing chamber according to a temperature value and a humidity value of the interior the testing chamber acquired by the temperature and humidity sensor, and if the dew point value of the air is greater than a pre-determined threshold, the main controller controls the cooling plate control unit to reduce the number of operating electronic cooling plates or output powers of the electronic cooling plates, wherein the pre-determined threshold is a temperature T1° C. of the electronic cooing plate or a temperature T1+n° C. of the electronic cooling plate acquired by the temperature sensor, and n≤is less than or equal to 10. The present disclosure achieves real-time control of operation states of the electronic cooling plates, thereby realizing redundant control of the cooling plates, and preventing the cooling plates from causing condensation in the chamber body, so as to achieve continuous operation when a failure occurs.

The present disclosure provides systems and methods for host cell improvement utilizing epistatic effects. The systems and methods described herein are host cell agnostic and therefore can be implemented across taxa. Furthermore, the disclosed systems and methods can be implemented to modulate or improve any host cell parameter of interest.

The present disclosure is directed to opposables including a body having a plurality of cavities disposed therein. Each cavity can be designed to contain one or more reagents, liquids, or fluids which may be applied to a specimen-bearing surface. In some embodiments, the cavities include one or more reagent chambers, the reagent chambers can have one or more seals such that the reagents, liquids, or fluids contained therein may be stored and released to the specimen-bearing surface.

An apparatus and method for bio-particle detection are provided. The apparatus for bio-particle detection includes: a bio-particle detection chip including a substrate having a plurality of through-hole groups, each through-hole group of the plurality of through-hole groups including through-holes which pass through the substrate from a first surface of the substrate toward an second surface of the substrate opposite to the first surface, and which are configured to accommodate a sample solution loaded therein; and a processor configured to determine a number of through-holes, among the through holes of at least one through-hole group of the plurality of through-hole groups, having a target material encapsulated therein, based on at least one of an electrical signal and an optical signal corresponding to the through-holes of the at least one through-hole group, and to estimate a concentration of the target material based on the determined number.

There is provided a temperature chamber including: a heat transfer member in which a bottom wall and side walls are integrated; a recessed portion surrounded by the bottom wall and the side walls; and a heat source member that is configured to heat and/or cool the heat transfer member.

Systems and methods for refrigerated storage of controls and calibrators utilize a refrigerant storage assembly having an insulated housing and door assembly, thermoelectric coolers, and the refrigerated base assembly having a metal plate thermally coupled to coolers, one or more sensors, and a plurality of receptacles to receive fluid tubes. Refrigerated storage provides a refrigerated environment suitable for multi-day storage of control and calibrator fluids.

Cryogenic devices are provided in which solid carbon dioxide (dry ice) is used to maintain a temperature zone in which samples can be manipulated under conditions in which the sample is maintained at a temperature below −50° C.

Systems and methods here may be configured for cooling and examining materials. In some example embodiments, the system may include a main thermoconductive body with indentations on the top surface, a bottom surface having legs structures along the edge, wherein the bottom surface and the plurality of leg structures form a partially enclosed bottom chamber, and a center channel connecting the top surface and the bottom chamber.

A microscope for microscopic examination of a sample includes: a microscope housing enclosing an illumination optics, a microscope stage, and an imaging optics; an integrated sample chamber located within the microscope housing; and an integrated reagent chamber located within the microscope housing, the integrated reagent chamber supplying a reagent to the sample.