A metallic sample holder includes an array of wells, wherein each well of the array is adapted to capture a sample volume. A first sector of the array comprises wells that are loaded with a first reagent of a first dried or freeze-dried nucleic acid amplification test reagent. A second sector of the array comprises wells that are loaded with a second reagent of a second dried or freeze-dried nucleic acid amplification test reagent.

The present invention discloses a multi-function polymerase chain reaction device, which utilizes a movable multi-functional top cover to make an equipment can selectively perform variable temperature PCR (Polymerase Chain Reaction) or constant temperature PCR, which the flexibility of test-application is highly raised.

Apparatus, systems, chips, and methods of performing a large number of simultaneous chemical reactions are provided herein. The chips of the invention comprise addressable units that can be addressed according to the temperature of the reaction to be run. The subject apparatus, systems, and chips are particularly suited for performing polymerase chain reactions on thousands of nucleic acid sequences, up to and including sequences of an entire genuine of an organism of interest.

The disclosed embodiments relate to the design of a preconcentrator system for preconcentrating air samples. This preconcentrator system includes a plurality of preconcentrators that preconcentrate the air samples prior to chemical analysis, and a delivery structure comprising a manifold that selectively routes a sample airflow to the plurality of concentrators so that the plurality of preconcentrators receive a sample airflow concurrently or individually.

Techniques are provided for a microfluidic chip for performing a microfluidic reaction. The microfluidic chip includes a rigid layer, a first polymer layer that forms a first surface of a microfluidic chamber within the microfluidic chip, a first adhesive layer disposed between the rigid layer and the first polymer layer, and a second polymer layer that forms a second surface of the microfluidic chamber, and a first port connecting an exterior of the microfluidic chip to the microfluidic chamber through at least the rigid layer, the first polymer layer, and the first adhesive layer. A first self-sealing valve is formed in the first polymer layer and disposed within the first port, the first self-sealing valve configured to seal directly against the rigid layer through a first gap in the first adhesive layer in response to pressure from thermal expansion of a fluid within the microfluidic chamber.

The present disclosure provides cryogenic storage systems and methods of using the cryogenic storage systems. A cryogenic storage system of the present disclosure may comprise a cryogenic tank with an inner door and an outer door, and a robot apparatus located adjacent to the cryogenic tank. The cryogenic tank may store multiple racks such that at most a single rack is removable through the inner door or the outer door. The cryogenic tank may store the multiple racks in multiple groups of racks comprising a first group of racks located at a first radial distance and a second group of racks located at a second radial distance that is greater than the first radial distance. The robot apparatus may selectively open and close the inner or outer doors, and insert or withdraw the single rack into or out of the cryogenic tank through the inner door or the outer door.

Cryogenic devices are provided in which solid carbon dioxide (dry ice) is used to maintain a temperature zone in which samples can be manipulated under conditions in which the sample is maintained at a temperature below −50° C.

Provided are a microfluidic detection system for a refrigerator and the refrigerator. The microfluidic detection system comprises: a microfluidic biochip that has a sample inlet, a detection pool and a communication port, all of which communicate in sequence by means of a microfluidic channel; a sample liquid driving device in sealed communication with the communication port by means of a sealed docking mechanism; and a detection mechanism for detecting the detection cell to obtain preset detection parameters of a sample liquid. The communication port is fixedly provided with a plug pin-having an internal flow channel in sealed communication with the communication port, the plug pin is inserted into and forms a fluid-tight connection with the sealed docking mechanism, and the sealed docking mechanism is in fluid-tight connection with the sample liquid driving device, so that the sample liquid driving device is in sealed communication with the communication port.

Reagent cartridges and related systems and methods for controlling reagent temperature are disclosed. In accordance with an implementation, an apparatus includes a system and a reagent cartridge. The system includes a reagent cartridge receptacle, a non-contact temperature controller, a processor operatively coupled to the temperature controller. The reagent cartridge is receivable within the reagent cartridge receptacle and includes a flow cell assembly, a plurality of reagent reservoirs, and a manifold assembly. The manifold assembly includes a common fluidic line and a plurality of reagent fluidic lines. Each of the plurality of reagent fluidic lines is adapted to be fluidically coupled to a corresponding reagent reservoir and selectively couplable to the common fluidic line. The processor is to cause the temperature controller to change a temperature of at least one of the common fluidic line or one or more of the reagent fluidic lines.

Provided herein are portable biocontainment devices for safe and reliable collection of biological samples, including liquid and gas samples. A sample inlet for collecting fluids and/or gases, including oral fluids and expired breath samples, is connected to a container having a climate-controlled container reservoir. One or more sample containers are connected to the sample inlet for collection of samples. The devices are configured for safe transport and handling of samples, while maintaining sample viability, including for relatively long transport periods. Safety components integrated within the device facilitates safe and effective decontamination of contagious samples. In this manner, aborting the sample preservation by decontamination prior to a hazardous release is achieved within the same apparatus.