The present disclosure is drawn to inertial pumps. An inertial pump can include a microfluidic channel, a fluid actuator located in the microfluidic channel, and a check valve located in the microfluidic channel. The check valve can include a moveable valve clement, a narrowed channel segment located upstream of the moveable valve element, and a blocking element formed in the microfluidic channel downstream of the moveable valve element. The narrowed channel segment can have a width less than a width of the moveable valve element so that the moveable valve element can block fluid flow through the check valve when the moveable valve element is positioned in the narrowed channel segment. The blocking element can be configured such that the blocking element constrains the moveable valve element within the check valve while also allowing fluid flow when the moveable valve element is positioned against the blocking element.

Methods and systems and related compositions for separating through a solid matrix a mixture comprising a nucleic acid together with a target compound having a water solubility equal to or greater than 0.01 mg per 100 mL, which can be used for managing fluid flow, biochemical reactions and purification of the nucleic acid or other target analytes.

An analytical toilet comprising a bowl for receiving excreta from a user; a flush mechanism for cleaning the bowl after use; at least one analytical test device wherein a sample of excreta is analyzed; a manifold comprising conduits and valves for distributing one or more fluids to and from the at least one receptacle; and a digital control device controlling the valves to distribute the sample to the analytical test device for analysis; and distribute fluid to remove the sample from the analytical test device after analysis and to clean the analytical test device is disclosed.

A reagent container according to an embodiment is used in an automatic analyzing system configured to measure a liquid mixture of a tested specimen and a reagent. The reagent container includes a case, a bag, and an outlet. The case is stored in a reagent storage. The bag is built in the case, is more flexible than the case, and is configured to contain the reagent. The reagent is taken out through the outlet.

A microfluidic device includes an input source characterized by a source pressure, an input channel in fluid communication with the input source, and an output channel. The microfluidic device also includes a normally closed valve having a closed state and an open state. The normally closed valve is disposed between the input channel and the output channel. The microfluidic device further includes one or more release chambers coupled to a pressure source. Activation of the pressure source deforms the one or more release chambers, placing the normally closed valve in the open state.

A sample preparation module accepts a sample including a target analyte. The sample preparation module processes the sample through several reaction chambers and a solid phase column. Different reagents are present in the reaction chambers. The eluted analyte is then transferred to the amplification module, where it is further processed and amplified for optical analysis.

Reagent cartridges and related systems and methods for controlling reagent temperature are disclosed. In accordance with an implementation, an apparatus includes a system and a reagent cartridge. The system includes a reagent cartridge receptacle, a non-contact temperature controller, a processor operatively coupled to the temperature controller. The reagent cartridge is receivable within the reagent cartridge receptacle and includes a flow cell assembly, a plurality of reagent reservoirs, and a manifold assembly. The manifold assembly includes a common fluidic line and a plurality of reagent fluidic lines. Each of the plurality of reagent fluidic lines is adapted to be fluidically coupled to a corresponding reagent reservoir and selectively couplable to the common fluidic line. The processor is to cause the temperature controller to change a temperature of at least one of the common fluidic line or one or more of the reagent fluidic lines.

A biological fluid dilution device can include a syringe body including a diluent chamber at a front end of the syringe body and a piston tube at a rear end of the syringe body. The diluent chamber can be partially filled with a diluent fluid. A moveable piston can be slidably engaged in the piston tube and form a fluid-tight seal with an interior surface of the piston tube. The moveable piston can include a metering groove to contain a precise volume of a biological fluid between the metering groove and the interior surface of the piston tube. A biological fluid inlet on the piston tube can be capable of delivering the biological fluid to the metering groove. The moveable piston can be slidable toward to diluent chamber to introduce the biological fluid in the metering groove into the diluent chamber.

The disclosure relates to a microfluidic system for the screening of polymorphs, morphology, and crystallization kinetics under well-mixed, continuous-flow at controlled supersaturations. The disclosure also relates to a method for screening crystalline polymorphs and morphology, and crystallization kinetics. The microfluidic system includes a microfluidic chamber having one or more inlets, a passive mixing zone, and a trap zone. The passive mixing zone promotes mixing of solvent, solute, and optionally antisolvent under stable, controlled levels of supersaturation. The trap zone similarly has stable, controlled levels of supersaturation and correspondingly low velocity to retain solute crystals formed in the trap zone for time-dependent evaluation.

A microfluidic system includes a substrate, a set of input ports coupled to the substrate, and a set of output ports coupled to the substrate. The microfluidic system also includes a microfluidic processing system coupled to the substrate and including a plurality of processing sites. The microfluidic processing system is coupled to the set of input ports and the set of output ports. The microfluidic system further includes one or more microfluidic logic devices coupled to the substrate and operable to control at least a portion of the microfluidic processing system.